Chronotypes in middle‐aged women with polycystic ovary syndrome: A population‐based study
Abstract Introduction Circadian rhythm disruption has been associated with the risk of polycystic ovary syndrome (PCOS), as the evening chronotype (EC) shares several traits with PCOS, including metabolic disorders, cardiovascular diseases, and psychiatric disorders. It has been suggested that the b...
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Wiley
2024-12-01
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| Series: | Acta Obstetricia et Gynecologica Scandinavica |
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| Online Access: | https://doi.org/10.1111/aogs.14991 |
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| author | Linnea Kroneld Päivi Polo‐Kantola Meri‐Maija Ollila Riikka K. Arffman Elisa Hurskainen Laure Morin‐Papunen Varpu Jokimaa Terhi T. Piltonen |
| author_facet | Linnea Kroneld Päivi Polo‐Kantola Meri‐Maija Ollila Riikka K. Arffman Elisa Hurskainen Laure Morin‐Papunen Varpu Jokimaa Terhi T. Piltonen |
| author_sort | Linnea Kroneld |
| collection | DOAJ |
| description | Abstract Introduction Circadian rhythm disruption has been associated with the risk of polycystic ovary syndrome (PCOS), as the evening chronotype (EC) shares several traits with PCOS, including metabolic disorders, cardiovascular diseases, and psychiatric disorders. It has been suggested that the biological clock could be targeted with new, preventive, and therapeutic strategies for PCOS in women with biorhythm disorders. We evaluated inner circadian rhythmicity in middle‐aged women with PCOS in a population‐based setting, focusing on whether women with PCOS and an EC have a specific subtype in relation to their clinical characteristics. Material and Methods The data derived from the Northern Finland Birth Cohort, a population‐based longitudinal birth cohort of 12 058 individuals born in 1966. We compared the circadian phenotype between 314 women with PCOS (according to the Rotterdam criteria) and 1248 women without PCOS at age 46 years using the validated Finnish shortened 6‐item Morningness‐Eveningness Questionnaire (sMEQ) and the single‐item self‐assessed morningness‐eveningness question. Results PCOS was not associated with the EC by the sMEQ (p = 0.495) or self‐assessment (p = 0.303). The self‐assessed morningness‐eveningness values differed from the sMEQ chronotype distribution (p < 0.001), nevertheless, the most frequent chronotype was the intermediate chronotype (IC) determined by both chronotyping methods (sMEQ PCOS 47.7% vs. 45.2% non‐PCOS; self‐assessment PCOS 66.5% vs. 68.4% non‐PCOS). The hyperandrogenic PCOS phenotypes A–C did not differ from the non‐hyperandrogenic phenotype D as for the chronotype (p = 0.271). The EC was associated in both groups with depressive and anxiety symptoms (PCOS p = 0.012, non‐PCOS p < 0.001) and the use of sleep medication (PCOS p = 0.017, non‐PCOS p < 0.001). Conclusions The EC was not over‐represented in middle‐aged women with PCOS or in the hyperandrogenic PCOS phenotypes A–C in our study. This does not support the need for chronotyping in the comprehensive assessment of women with PCOS. However, as chronotypes tend to change with aging, cross‐sectional studies in different age groups are warranted to draw conclusions on the role of chronotypes in PCOS and the associated metabolic risks. |
| format | Article |
| id | doaj-art-64ec11d7dc894a4297f2414195c2c7d2 |
| institution | Kabale University |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
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| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-64ec11d7dc894a4297f2414195c2c7d22025-08-20T03:31:00ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04122024-12-01103122554256510.1111/aogs.14991Chronotypes in middle‐aged women with polycystic ovary syndrome: A population‐based studyLinnea Kroneld0Päivi Polo‐Kantola1Meri‐Maija Ollila2Riikka K. Arffman3Elisa Hurskainen4Laure Morin‐Papunen5Varpu Jokimaa6Terhi T. Piltonen7Department of Obstetrics and Gynecology University of Turku and Turku University Hospital Turku FinlandDepartment of Obstetrics and Gynecology University of Turku and Turku University Hospital Turku FinlandDepartment of Obstetrics and Gynecology University of Oulu and Oulu University Hospital, Research Unit of Clinical Medicine, Medical Research Center Oulu FinlandDepartment of Obstetrics and Gynecology University of Oulu and Oulu University Hospital, Research Unit of Clinical Medicine, Medical Research Center Oulu FinlandDepartment of Obstetrics and Gynecology University of Oulu and Oulu University Hospital, Research Unit of Clinical Medicine, Medical Research Center Oulu FinlandDepartment of Obstetrics and Gynecology University of Oulu and Oulu University Hospital, Research Unit of Clinical Medicine, Medical Research Center Oulu FinlandDepartment of Obstetrics and Gynecology University of Turku and Turku University Hospital Turku FinlandDepartment of Obstetrics and Gynecology University of Oulu and Oulu University Hospital, Research Unit of Clinical Medicine, Medical Research Center Oulu FinlandAbstract Introduction Circadian rhythm disruption has been associated with the risk of polycystic ovary syndrome (PCOS), as the evening chronotype (EC) shares several traits with PCOS, including metabolic disorders, cardiovascular diseases, and psychiatric disorders. It has been suggested that the biological clock could be targeted with new, preventive, and therapeutic strategies for PCOS in women with biorhythm disorders. We evaluated inner circadian rhythmicity in middle‐aged women with PCOS in a population‐based setting, focusing on whether women with PCOS and an EC have a specific subtype in relation to their clinical characteristics. Material and Methods The data derived from the Northern Finland Birth Cohort, a population‐based longitudinal birth cohort of 12 058 individuals born in 1966. We compared the circadian phenotype between 314 women with PCOS (according to the Rotterdam criteria) and 1248 women without PCOS at age 46 years using the validated Finnish shortened 6‐item Morningness‐Eveningness Questionnaire (sMEQ) and the single‐item self‐assessed morningness‐eveningness question. Results PCOS was not associated with the EC by the sMEQ (p = 0.495) or self‐assessment (p = 0.303). The self‐assessed morningness‐eveningness values differed from the sMEQ chronotype distribution (p < 0.001), nevertheless, the most frequent chronotype was the intermediate chronotype (IC) determined by both chronotyping methods (sMEQ PCOS 47.7% vs. 45.2% non‐PCOS; self‐assessment PCOS 66.5% vs. 68.4% non‐PCOS). The hyperandrogenic PCOS phenotypes A–C did not differ from the non‐hyperandrogenic phenotype D as for the chronotype (p = 0.271). The EC was associated in both groups with depressive and anxiety symptoms (PCOS p = 0.012, non‐PCOS p < 0.001) and the use of sleep medication (PCOS p = 0.017, non‐PCOS p < 0.001). Conclusions The EC was not over‐represented in middle‐aged women with PCOS or in the hyperandrogenic PCOS phenotypes A–C in our study. This does not support the need for chronotyping in the comprehensive assessment of women with PCOS. However, as chronotypes tend to change with aging, cross‐sectional studies in different age groups are warranted to draw conclusions on the role of chronotypes in PCOS and the associated metabolic risks.https://doi.org/10.1111/aogs.14991chronotypecircadian rhythmMEQmorningness‐eveningnessPCOSpolycystic ovary syndrome |
| spellingShingle | Linnea Kroneld Päivi Polo‐Kantola Meri‐Maija Ollila Riikka K. Arffman Elisa Hurskainen Laure Morin‐Papunen Varpu Jokimaa Terhi T. Piltonen Chronotypes in middle‐aged women with polycystic ovary syndrome: A population‐based study Acta Obstetricia et Gynecologica Scandinavica chronotype circadian rhythm MEQ morningness‐eveningness PCOS polycystic ovary syndrome |
| title | Chronotypes in middle‐aged women with polycystic ovary syndrome: A population‐based study |
| title_full | Chronotypes in middle‐aged women with polycystic ovary syndrome: A population‐based study |
| title_fullStr | Chronotypes in middle‐aged women with polycystic ovary syndrome: A population‐based study |
| title_full_unstemmed | Chronotypes in middle‐aged women with polycystic ovary syndrome: A population‐based study |
| title_short | Chronotypes in middle‐aged women with polycystic ovary syndrome: A population‐based study |
| title_sort | chronotypes in middle aged women with polycystic ovary syndrome a population based study |
| topic | chronotype circadian rhythm MEQ morningness‐eveningness PCOS polycystic ovary syndrome |
| url | https://doi.org/10.1111/aogs.14991 |
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