Case Report: Rare multisystem metastasis in head and neck paraganglioma with SDHB pathogenic variant and KIF1B VUS manifested as FUO

Case Report: Rare multisystem metastasis in head and neck paraganglioma with SDHB pathogenic variant and KIF1B VUS manifested as FUO

BackgroundParagangliomas (PGLs) are rare neuroendocrine tumors originating from the extra-adrenal autonomic paraganglia with a strong genetic background. SDHB pathogenic variants are associated with the highest rate of malignancy in PGLs. Most head and neck paragangliomas (HNPGs) are asymptomatic an...

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Bibliographic Details
Main Authors: Yongshi Yang, Xiaotong Tian, Congwei Jia, Hongwei Fan, Taisheng Li, Li Zhang, Zhengyin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Endocrinology
Subjects:
paraganglioma
metastasis
SDHB
case report
gene variant
FUO
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1612259/full
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