Signaling Pathway of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and Potential Therapeutic Targets for Regulating the Gut Microbiota of Individuals with Gallstone Disease
Gallstone disease (GD) poses a substantial health challenge worldwide, and its complications are often associated with disturbances in the gut microbiota. The essential receptor through which the innate immune system detects bacterial components and controls inflammation, namely, nucleotide-binding...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2025-01-01
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| Series: | Journal of Bio-X Research |
| Online Access: | https://spj.science.org/doi/10.34133/jbioxresearch.0031 |
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| author | Sanjana Murali Nandini Krishnamurthy R. B. Devi Krishna Shanthi Vijayaraghavan S. Rajesh Kumar Andrea Mary Francis |
| author_facet | Sanjana Murali Nandini Krishnamurthy R. B. Devi Krishna Shanthi Vijayaraghavan S. Rajesh Kumar Andrea Mary Francis |
| author_sort | Sanjana Murali |
| collection | DOAJ |
| description | Gallstone disease (GD) poses a substantial health challenge worldwide, and its complications are often associated with disturbances in the gut microbiota. The essential receptor through which the innate immune system detects bacterial components and controls inflammation, namely, nucleotide-binding oligomerization domain-containing protein 1 (NOD1), is a major participant in the interaction. This article examines the role of NOD1 in GD, focusing on how gallstone-induced changes in the gut microbiota composition activate NOD1. Such activation initiates signaling pathways that lead to gut dysbiosis, further exacerbating GD. We investigate potential therapeutic targets within the NOD1 signaling pathway and its interactions with other host factors, suggesting methods to restore imbalances in the gut microbiota and improve GD management. The clinical significance of these findings and future research directions are also discussed, highlighting the importance of comprehensive approaches to treat GD by targeting NOD1 activity and the gut microbiota. |
| format | Article |
| id | doaj-art-64e2403344ec43fc95f89887e605196e |
| institution | Kabale University |
| issn | 2577-3585 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Journal of Bio-X Research |
| spelling | doaj-art-64e2403344ec43fc95f89887e605196e2025-01-31T08:00:19ZengAmerican Association for the Advancement of Science (AAAS)Journal of Bio-X Research2577-35852025-01-01810.34133/jbioxresearch.0031Signaling Pathway of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and Potential Therapeutic Targets for Regulating the Gut Microbiota of Individuals with Gallstone DiseaseSanjana Murali0Nandini Krishnamurthy1R. B. Devi Krishna2Shanthi Vijayaraghavan3S. Rajesh Kumar4Andrea Mary Francis5Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.Department of Hepatology, Sri Ramachandra Medical Centre, Chennai, Tamil Nadu, India.Department of Nanobiomedicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.Gallstone disease (GD) poses a substantial health challenge worldwide, and its complications are often associated with disturbances in the gut microbiota. The essential receptor through which the innate immune system detects bacterial components and controls inflammation, namely, nucleotide-binding oligomerization domain-containing protein 1 (NOD1), is a major participant in the interaction. This article examines the role of NOD1 in GD, focusing on how gallstone-induced changes in the gut microbiota composition activate NOD1. Such activation initiates signaling pathways that lead to gut dysbiosis, further exacerbating GD. We investigate potential therapeutic targets within the NOD1 signaling pathway and its interactions with other host factors, suggesting methods to restore imbalances in the gut microbiota and improve GD management. The clinical significance of these findings and future research directions are also discussed, highlighting the importance of comprehensive approaches to treat GD by targeting NOD1 activity and the gut microbiota.https://spj.science.org/doi/10.34133/jbioxresearch.0031 |
| spellingShingle | Sanjana Murali Nandini Krishnamurthy R. B. Devi Krishna Shanthi Vijayaraghavan S. Rajesh Kumar Andrea Mary Francis Signaling Pathway of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and Potential Therapeutic Targets for Regulating the Gut Microbiota of Individuals with Gallstone Disease Journal of Bio-X Research |
| title | Signaling Pathway of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and Potential Therapeutic Targets for Regulating the Gut Microbiota of Individuals with Gallstone Disease |
| title_full | Signaling Pathway of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and Potential Therapeutic Targets for Regulating the Gut Microbiota of Individuals with Gallstone Disease |
| title_fullStr | Signaling Pathway of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and Potential Therapeutic Targets for Regulating the Gut Microbiota of Individuals with Gallstone Disease |
| title_full_unstemmed | Signaling Pathway of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and Potential Therapeutic Targets for Regulating the Gut Microbiota of Individuals with Gallstone Disease |
| title_short | Signaling Pathway of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and Potential Therapeutic Targets for Regulating the Gut Microbiota of Individuals with Gallstone Disease |
| title_sort | signaling pathway of nucleotide binding oligomerization domain containing protein 1 and potential therapeutic targets for regulating the gut microbiota of individuals with gallstone disease |
| url | https://spj.science.org/doi/10.34133/jbioxresearch.0031 |
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