The effect of 12 weeks of aerobic training and food restriction on dopaminergic and catalepsy neurons in the brain tissue of Parkinson\'s disease model of rats
Background and Aim: Parkinson's disease is a prevalent neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and the presence of catalepsy. This study aimed to investigate the effects of 12 weeks of aerobic training and food restriction on dopaminergic and catalep...
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Kashan University of Medical Sciences
2024-04-01
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| Series: | مجله علوم پزشکی فیض (پیوسته) |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-5093-en.pdf |
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| author | Sima Movahed Jabbar Bashiri Hasan Pourrazi Roghayeh Pozesh Jadidi |
| author_facet | Sima Movahed Jabbar Bashiri Hasan Pourrazi Roghayeh Pozesh Jadidi |
| author_sort | Sima Movahed |
| collection | DOAJ |
| description | Background and Aim: Parkinson's disease is a prevalent neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and the presence of catalepsy. This study aimed to investigate the effects of 12 weeks of aerobic training and food restriction on dopaminergic and catalepsy neurons in the brain tissue of Parkinson's disease model of rats.
Methods: In this experimental study, 40 male Wistar rats aged 2-3 months were randomly divided into five groups (n=8): healthy control (C), Parkinson's disease model (P), Parkinson's disease model + aerobic training (P+T), Parkinson's disease model + food restriction (P+FR), and Parkinson's disease model + aerobic training + food restriction (P+T+FR). The aerobic training regimen consisted of three months with five sessions per week at an intensity of 75-80% of maximum oxygen consumption. The food restriction group received approximately 11 grams of food daily. Catalepsy was assessed using the rod test, while dopaminergic neurons were quantified through brain sectioning and microscopic counting.
Results: The P+T+FR group exhibited a significant increase in dopaminergic neuron count compared to the C, P, P+T, and P+FR groups (P=0.001). Furthermore, a significant reduction in catalepsy was observed in the P+T+RF group compared to the P group (P=0.001).
Conclusion: The combination of three months of aerobic training and food restriction resulted in improvements in dopaminergic neuron count and reduced catalepsy in a rat model of Parkinson's disease. These findings suggest that aerobic training and food restriction could serve as potential complementary interventions for Parkinson's disease treatment, alongside pharmacological approaches, warranting further investigation in this area. |
| format | Article |
| id | doaj-art-64df260d4e594207800d3c704c281822 |
| institution | DOAJ |
| issn | 3060-5806 3060-5814 |
| language | fas |
| publishDate | 2024-04-01 |
| publisher | Kashan University of Medical Sciences |
| record_format | Article |
| series | مجله علوم پزشکی فیض (پیوسته) |
| spelling | doaj-art-64df260d4e594207800d3c704c2818222025-08-20T02:51:19ZfasKashan University of Medical Sciencesمجله علوم پزشکی فیض (پیوسته)3060-58063060-58142024-04-01282132140The effect of 12 weeks of aerobic training and food restriction on dopaminergic and catalepsy neurons in the brain tissue of Parkinson\'s disease model of ratsSima Movahed0Jabbar Bashiri1Hasan Pourrazi2Roghayeh Pozesh Jadidi3 Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran Department of Physical Education and Sports Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran Background and Aim: Parkinson's disease is a prevalent neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and the presence of catalepsy. This study aimed to investigate the effects of 12 weeks of aerobic training and food restriction on dopaminergic and catalepsy neurons in the brain tissue of Parkinson's disease model of rats. Methods: In this experimental study, 40 male Wistar rats aged 2-3 months were randomly divided into five groups (n=8): healthy control (C), Parkinson's disease model (P), Parkinson's disease model + aerobic training (P+T), Parkinson's disease model + food restriction (P+FR), and Parkinson's disease model + aerobic training + food restriction (P+T+FR). The aerobic training regimen consisted of three months with five sessions per week at an intensity of 75-80% of maximum oxygen consumption. The food restriction group received approximately 11 grams of food daily. Catalepsy was assessed using the rod test, while dopaminergic neurons were quantified through brain sectioning and microscopic counting. Results: The P+T+FR group exhibited a significant increase in dopaminergic neuron count compared to the C, P, P+T, and P+FR groups (P=0.001). Furthermore, a significant reduction in catalepsy was observed in the P+T+RF group compared to the P group (P=0.001). Conclusion: The combination of three months of aerobic training and food restriction resulted in improvements in dopaminergic neuron count and reduced catalepsy in a rat model of Parkinson's disease. These findings suggest that aerobic training and food restriction could serve as potential complementary interventions for Parkinson's disease treatment, alongside pharmacological approaches, warranting further investigation in this area.http://feyz.kaums.ac.ir/article-1-5093-en.pdfparkinson'sfood restrictionaerobic trainingcatalepsydopaminergic neurons |
| spellingShingle | Sima Movahed Jabbar Bashiri Hasan Pourrazi Roghayeh Pozesh Jadidi The effect of 12 weeks of aerobic training and food restriction on dopaminergic and catalepsy neurons in the brain tissue of Parkinson\'s disease model of rats مجله علوم پزشکی فیض (پیوسته) parkinson's food restriction aerobic training catalepsy dopaminergic neurons |
| title | The effect of 12 weeks of aerobic training and food restriction on dopaminergic and catalepsy neurons in the brain tissue of Parkinson\'s disease model of rats |
| title_full | The effect of 12 weeks of aerobic training and food restriction on dopaminergic and catalepsy neurons in the brain tissue of Parkinson\'s disease model of rats |
| title_fullStr | The effect of 12 weeks of aerobic training and food restriction on dopaminergic and catalepsy neurons in the brain tissue of Parkinson\'s disease model of rats |
| title_full_unstemmed | The effect of 12 weeks of aerobic training and food restriction on dopaminergic and catalepsy neurons in the brain tissue of Parkinson\'s disease model of rats |
| title_short | The effect of 12 weeks of aerobic training and food restriction on dopaminergic and catalepsy neurons in the brain tissue of Parkinson\'s disease model of rats |
| title_sort | effect of 12 weeks of aerobic training and food restriction on dopaminergic and catalepsy neurons in the brain tissue of parkinson s disease model of rats |
| topic | parkinson's food restriction aerobic training catalepsy dopaminergic neurons |
| url | http://feyz.kaums.ac.ir/article-1-5093-en.pdf |
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