A detailed review of bovine brucellosis

Bovine brucellosis, a prevalent zoonotic disease, is caused by the bacterium Brucella abortus, which can infect both humans and animals. This review article aims to provide a full explanation of the causes, historical background, occurrence, development, clinical manifestations, diagnosis, spread, v...

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Main Authors: Saifur Rehman, Shakeeb Ullah, Kholik Kholik, Muhammad Munawaroh, Akhmad Sukri, Muhammad Inam Ullah Malik, Munawer Pradana, Erprinanda Galuh Berliana, Mariyam Al Haddar, Iwan Doddy Dharmawibawa, Rashid Manzoor, Teguh Hari Sucipto
Format: Article
Language:English
Published: Tripoli University 2025-04-01
Series:Open Veterinary Journal
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Online Access:http://www.ejmanager.com/fulltextpdf.php?mno=231525
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author Saifur Rehman
Shakeeb Ullah
Kholik Kholik
Muhammad Munawaroh
Akhmad Sukri
Muhammad Inam Ullah Malik
Munawer Pradana
Erprinanda Galuh Berliana
Mariyam Al Haddar
Iwan Doddy Dharmawibawa
Rashid Manzoor
Teguh Hari Sucipto
author_facet Saifur Rehman
Shakeeb Ullah
Kholik Kholik
Muhammad Munawaroh
Akhmad Sukri
Muhammad Inam Ullah Malik
Munawer Pradana
Erprinanda Galuh Berliana
Mariyam Al Haddar
Iwan Doddy Dharmawibawa
Rashid Manzoor
Teguh Hari Sucipto
author_sort Saifur Rehman
collection DOAJ
description Bovine brucellosis, a prevalent zoonotic disease, is caused by the bacterium Brucella abortus, which can infect both humans and animals. This review article aims to provide a full explanation of the causes, historical background, occurrence, development, clinical manifestations, diagnosis, spread, variables that increase the risk, importance to public health, economic impact, treatment, and methods of controlling bovine brucellosis. Bovine tuberculosis primarily affects cattle although it can also affect other animals. Bovine brucellosis is a global illness that occurs in all regions of the world, with the exception of Antarctica. Cattle afflicted with bovine brucellosis may suffer from persistent and incapacitating illness. The main techniques used to identify Brucella infection are serological assays, such as the Rose Bengal plate test (RBPT), milk ring test (MRT), serum agglutination test (SAT), and enzyme-linked immunosorbent assay (ELISA). The prevalence of Brucellosis exhibits significant variation as a result of disparities in the precision and efficacy of serological tests. Brucella abortus can be found in various physiological fluids and tissues, such as milk, urine, feces, vaginal secretions, semen, bones, joints, male reproductive organs, placenta, and the fetuses of pregnant women. This condition commonly decreases cow productivity and can negatively impact the financial performance of livestock businesses, particularly dairy sectors. The most effective initial treatment for brucellosis is isoniazid, doxycycline, and streptomycin. The vaccine strains most frequently employed to protect cattle against Brucella infection and related abortions are strains 19 and RB51. Research has shown that bacteriophage lysates are effective for treating bovine brucellosis. Adopting a One Health strategy can help effectively treat this illness by considering the health of both animals and humans. [Open Vet J 2025; 15(4.000): 1520-1535]
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spelling doaj-art-64ddfc22df12454d9d4a28451d36e7bf2025-08-20T03:09:38ZengTripoli UniversityOpen Veterinary Journal2226-44852218-60502025-04-011541520153510.5455/OVJ.2025.v15.i4.2231525A detailed review of bovine brucellosisSaifur Rehman0Shakeeb Ullah1Kholik Kholik2Muhammad Munawaroh3Akhmad Sukri4Muhammad Inam Ullah Malik5Munawer Pradana6Erprinanda Galuh Berliana7Mariyam Al Haddar8Iwan Doddy Dharmawibawa9Rashid Manzoor10Teguh Hari Sucipto112Faculty of Veterinary and Animal Sciences, Gomal University, RV9W+GVJ, Indus HWY, Dera Ismail Khan 29111, Khyber Pakhtunkhwa, Pakistan Faculty of Veterinary and Animal Sciences, Gomal University, RV9W+GVJ, Indus HWY, Dera Ismail Khan 29111, Khyber Pakhtunkhwa, Pakistan 3Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Pemuda No.59A, Mataram City 83125, Indonesia 4Department of Basic Medical Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Pemuda No.59A, Mataram City 83125, Indonesia 5Departement of Biology Education,, Universitas Pendidikan Mandalika, Jl. Pemuda No.59A, Mataram City 83125, Indonesia Faculty of Veterinary and Animal Sciences, Gomal University, RV9W+GVJ, Indus HWY, Dera Ismail Khan 29111, Khyber Pakhtunkhwa, Pakistan 6Department of Reproductive, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Jl. Pemuda No.59A, Mataram City 83125, Indonesia 6Department of Reproductive, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Jl. Pemuda No.59A, Mataram City 83125, Indonesia 7Departement of Feed and Nutrition, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Jl. Pemuda No.59A, Mataram City 83125, Indonesia 8Departement of Parasitology and Microbiology, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Jl.Pemuda No.59A, Mataram City 83125, Indonesia Faculty of Veterinary and Animal Sciences, Gomal University, RV9W+GVJ, Indus HWY, Dera Ismail Khan 29111, Khyber Pakhtunkhwa, Pakistan 9Dengue Study Group, Institute of Tropical Disease, Universitas Airlangga. Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, IndonesiaBovine brucellosis, a prevalent zoonotic disease, is caused by the bacterium Brucella abortus, which can infect both humans and animals. This review article aims to provide a full explanation of the causes, historical background, occurrence, development, clinical manifestations, diagnosis, spread, variables that increase the risk, importance to public health, economic impact, treatment, and methods of controlling bovine brucellosis. Bovine tuberculosis primarily affects cattle although it can also affect other animals. Bovine brucellosis is a global illness that occurs in all regions of the world, with the exception of Antarctica. Cattle afflicted with bovine brucellosis may suffer from persistent and incapacitating illness. The main techniques used to identify Brucella infection are serological assays, such as the Rose Bengal plate test (RBPT), milk ring test (MRT), serum agglutination test (SAT), and enzyme-linked immunosorbent assay (ELISA). The prevalence of Brucellosis exhibits significant variation as a result of disparities in the precision and efficacy of serological tests. Brucella abortus can be found in various physiological fluids and tissues, such as milk, urine, feces, vaginal secretions, semen, bones, joints, male reproductive organs, placenta, and the fetuses of pregnant women. This condition commonly decreases cow productivity and can negatively impact the financial performance of livestock businesses, particularly dairy sectors. The most effective initial treatment for brucellosis is isoniazid, doxycycline, and streptomycin. The vaccine strains most frequently employed to protect cattle against Brucella infection and related abortions are strains 19 and RB51. Research has shown that bacteriophage lysates are effective for treating bovine brucellosis. Adopting a One Health strategy can help effectively treat this illness by considering the health of both animals and humans. [Open Vet J 2025; 15(4.000): 1520-1535]http://www.ejmanager.com/fulltextpdf.php?mno=231525bovine brucellosisbrucella abortushuman infectious diseasepublic health
spellingShingle Saifur Rehman
Shakeeb Ullah
Kholik Kholik
Muhammad Munawaroh
Akhmad Sukri
Muhammad Inam Ullah Malik
Munawer Pradana
Erprinanda Galuh Berliana
Mariyam Al Haddar
Iwan Doddy Dharmawibawa
Rashid Manzoor
Teguh Hari Sucipto
A detailed review of bovine brucellosis
Open Veterinary Journal
bovine brucellosis
brucella abortus
human infectious disease
public health
title A detailed review of bovine brucellosis
title_full A detailed review of bovine brucellosis
title_fullStr A detailed review of bovine brucellosis
title_full_unstemmed A detailed review of bovine brucellosis
title_short A detailed review of bovine brucellosis
title_sort detailed review of bovine brucellosis
topic bovine brucellosis
brucella abortus
human infectious disease
public health
url http://www.ejmanager.com/fulltextpdf.php?mno=231525
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