Ubiquitination of CD47 Regulates Innate Anti‐Tumor Immune Response

Ubiquitination of CD47 Regulates Innate Anti‐Tumor Immune Response

Abstract In addition to adaptive immune checkpoint of PD‐1/PD‐L1, the innate immune checkpoint SIRPα/CD47 plays an important role in regulation of tumor immune escape. However, the mechanism of CD47 ubiquitination on tumor immune escape remains unclear. Here it is found that TRAF2 bound to the C‐ter...

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Bibliographic Details
Main Authors: Qian Gou, Bingjun Yan, Yalan Duan, Yilei Guo, Jing Qian, Juanjuan Shi, Yongzhong Hou
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
autophagy
CD47
immune escape
TRAF2
ubiquitination
Online Access:https://doi.org/10.1002/advs.202412205
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