Microbiota and gastric cancer: from molecular mechanisms to therapeutic strategies
Gastric cancer, a prevalent malignancy globally, is influenced by various factors. The imbalance in the gut microbiome and the existence of particular intratumoural microbiota could have a strong connection with the onset and progression of gastric cancer. High-throughput sequencing technology and b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1563061/full |
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| author | Zhou Chen Zhou Chen Dacheng Jin Dacheng Jin Jinjing Hu Jinjing Hu Jinjing Hu Defeng Guan Defeng Guan Qizhou Bai Qizhou Bai Yunjiu Gou Yunjiu Gou |
| author_facet | Zhou Chen Zhou Chen Dacheng Jin Dacheng Jin Jinjing Hu Jinjing Hu Jinjing Hu Defeng Guan Defeng Guan Qizhou Bai Qizhou Bai Yunjiu Gou Yunjiu Gou |
| author_sort | Zhou Chen |
| collection | DOAJ |
| description | Gastric cancer, a prevalent malignancy globally, is influenced by various factors. The imbalance in the gut microbiome and the existence of particular intratumoural microbiota could have a strong connection with the onset and progression of gastric cancer. High-throughput sequencing technology and bioinformatics analysis have revealed a close correlation between abnormal abundance of specific microbial communities and the risk of gastric cancer. These microbial communities contribute to gastric cancer progression through mechanisms including increasing cellular genomic damage, inhibiting DNA repair, activating abnormal signaling pathways, exacerbating tumor hypoxia, and shaping a tumor immune-suppressive microenvironment. This significantly impacts the efficacy of gastric cancer treatments, including chemotherapy and immunotherapy. Probiotic, prebiotic, antibiotic, carrier-based, dietary interventions, fecal microbiota transplantation, and traditional Chinese medicine show potential applications in gastric cancer treatment. However, the molecular mechanisms regarding dysbiosis of microbiota, including gut microbiota, and intra-tumoral microbiota during the progression of gastric cancer, as well as the therapeutic efficacy of microbiota-related applications, still require extensive exploration through experiments. |
| format | Article |
| id | doaj-art-64dd37f73d094128862c8cace75d7f28 |
| institution | OA Journals |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-64dd37f73d094128862c8cace75d7f282025-08-20T02:32:20ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-06-011510.3389/fcimb.2025.15630611563061Microbiota and gastric cancer: from molecular mechanisms to therapeutic strategiesZhou Chen0Zhou Chen1Dacheng Jin2Dacheng Jin3Jinjing Hu4Jinjing Hu5Jinjing Hu6Defeng Guan7Defeng Guan8Qizhou Bai9Qizhou Bai10Yunjiu Gou11Yunjiu Gou12Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe Third Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaDepartment of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe Third Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaDepartment of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe Third Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosisand Therapy of Gastrointestinal Tumor, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaReproductive Medicine Center, The First Hospital of Lanzhou University, Lanzhou, Gansu, ChinaDepartment of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe Third Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaDepartment of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe Third Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaGastric cancer, a prevalent malignancy globally, is influenced by various factors. The imbalance in the gut microbiome and the existence of particular intratumoural microbiota could have a strong connection with the onset and progression of gastric cancer. High-throughput sequencing technology and bioinformatics analysis have revealed a close correlation between abnormal abundance of specific microbial communities and the risk of gastric cancer. These microbial communities contribute to gastric cancer progression through mechanisms including increasing cellular genomic damage, inhibiting DNA repair, activating abnormal signaling pathways, exacerbating tumor hypoxia, and shaping a tumor immune-suppressive microenvironment. This significantly impacts the efficacy of gastric cancer treatments, including chemotherapy and immunotherapy. Probiotic, prebiotic, antibiotic, carrier-based, dietary interventions, fecal microbiota transplantation, and traditional Chinese medicine show potential applications in gastric cancer treatment. However, the molecular mechanisms regarding dysbiosis of microbiota, including gut microbiota, and intra-tumoral microbiota during the progression of gastric cancer, as well as the therapeutic efficacy of microbiota-related applications, still require extensive exploration through experiments.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1563061/fullgastric cancermicrobiotamolecular mechanismstumor microenvironmenttargeted therapy |
| spellingShingle | Zhou Chen Zhou Chen Dacheng Jin Dacheng Jin Jinjing Hu Jinjing Hu Jinjing Hu Defeng Guan Defeng Guan Qizhou Bai Qizhou Bai Yunjiu Gou Yunjiu Gou Microbiota and gastric cancer: from molecular mechanisms to therapeutic strategies Frontiers in Cellular and Infection Microbiology gastric cancer microbiota molecular mechanisms tumor microenvironment targeted therapy |
| title | Microbiota and gastric cancer: from molecular mechanisms to therapeutic strategies |
| title_full | Microbiota and gastric cancer: from molecular mechanisms to therapeutic strategies |
| title_fullStr | Microbiota and gastric cancer: from molecular mechanisms to therapeutic strategies |
| title_full_unstemmed | Microbiota and gastric cancer: from molecular mechanisms to therapeutic strategies |
| title_short | Microbiota and gastric cancer: from molecular mechanisms to therapeutic strategies |
| title_sort | microbiota and gastric cancer from molecular mechanisms to therapeutic strategies |
| topic | gastric cancer microbiota molecular mechanisms tumor microenvironment targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1563061/full |
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