The Effects of Mesenchymal Stem Cell on Colorectal Cancer
Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with nonobvious early symptoms and late symptoms of anemia, weight loss, and other systemic symptoms. Its morbidity and fatality rate are next only to gastric cancer, esophageal cancer, and primary liver cancer among d...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/9136583 |
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| author | Jintao Yuan Zhiping Wei Xinwei Xu Dickson Kofi Wiredu Ocansey Xiu Cai Fei Mao |
| author_facet | Jintao Yuan Zhiping Wei Xinwei Xu Dickson Kofi Wiredu Ocansey Xiu Cai Fei Mao |
| author_sort | Jintao Yuan |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with nonobvious early symptoms and late symptoms of anemia, weight loss, and other systemic symptoms. Its morbidity and fatality rate are next only to gastric cancer, esophageal cancer, and primary liver cancer among digestive malignancies. In addition to the conventional surgical intervention, other therapies such as radiotherapy and chemotherapy and new treatment methods such as biologics and microbiological products have been introduced. As a promising cell therapy, mesenchymal stem cell (MSC) has attracted extensive research attention. MSCs are early undifferentiated pluripotent stem cells, which have the common features of stem cells, including self-replication, self-division, self-renewal, and multidirectional differentiation. MSCs come from a wide range of sources and can be extracted from a variety of tissues such as the bone marrow, umbilical cord, and fat. Current studies have shown that MSCs have a variety of biological functions such as immune regulation, tissue damage repair, and therapeutic effects on tumors such as CRC. This review outlines the overview of MSCs and CRC and summarizes the role of MSC application in CRC. |
| format | Article |
| id | doaj-art-64dbadec4ff04d4985d61f2fe15a70ab |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-64dbadec4ff04d4985d61f2fe15a70ab2025-08-20T03:34:25ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/91365839136583The Effects of Mesenchymal Stem Cell on Colorectal CancerJintao Yuan0Zhiping Wei1Xinwei Xu2Dickson Kofi Wiredu Ocansey3Xiu Cai4Fei Mao5The People’s Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Zhenjiang, Jiangsu 212300, ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, 212013 Jiangsu, ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, 212013 Jiangsu, ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, 212013 Jiangsu, ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, 212013 Jiangsu, ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, 212013 Jiangsu, ChinaColorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with nonobvious early symptoms and late symptoms of anemia, weight loss, and other systemic symptoms. Its morbidity and fatality rate are next only to gastric cancer, esophageal cancer, and primary liver cancer among digestive malignancies. In addition to the conventional surgical intervention, other therapies such as radiotherapy and chemotherapy and new treatment methods such as biologics and microbiological products have been introduced. As a promising cell therapy, mesenchymal stem cell (MSC) has attracted extensive research attention. MSCs are early undifferentiated pluripotent stem cells, which have the common features of stem cells, including self-replication, self-division, self-renewal, and multidirectional differentiation. MSCs come from a wide range of sources and can be extracted from a variety of tissues such as the bone marrow, umbilical cord, and fat. Current studies have shown that MSCs have a variety of biological functions such as immune regulation, tissue damage repair, and therapeutic effects on tumors such as CRC. This review outlines the overview of MSCs and CRC and summarizes the role of MSC application in CRC.http://dx.doi.org/10.1155/2021/9136583 |
| spellingShingle | Jintao Yuan Zhiping Wei Xinwei Xu Dickson Kofi Wiredu Ocansey Xiu Cai Fei Mao The Effects of Mesenchymal Stem Cell on Colorectal Cancer Stem Cells International |
| title | The Effects of Mesenchymal Stem Cell on Colorectal Cancer |
| title_full | The Effects of Mesenchymal Stem Cell on Colorectal Cancer |
| title_fullStr | The Effects of Mesenchymal Stem Cell on Colorectal Cancer |
| title_full_unstemmed | The Effects of Mesenchymal Stem Cell on Colorectal Cancer |
| title_short | The Effects of Mesenchymal Stem Cell on Colorectal Cancer |
| title_sort | effects of mesenchymal stem cell on colorectal cancer |
| url | http://dx.doi.org/10.1155/2021/9136583 |
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