A directionally evolved genomic feature in BRSK2 harbors divergent alleles in neurocognitive disorders

A directionally evolved genomic feature in BRSK2 harbors divergent alleles in neurocognitive disorders

Abstract The human Brain-specific Serine/Threonine Kinase 2 (BRSK2), alternatively known as Synapses of Amphids Defective (SAD)-A, is mainly expressed in the brain, and required for neuronal polarization and differentiation. This gene contains the longest 5′ untranslated region (5′ UTR) pentanucleot...

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Bibliographic Details
Main Authors: M. Ohadi, H. Bayat, S. Khamse, A. Delbari, M. Arabfard
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Human
BRSK2
SAD-A
CGGCT
CGG
Neurocognitive disorder
Online Access:https://doi.org/10.1038/s41598-025-07803-y
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