Association between trace elements and dental caries in the USA: analysis of data from serial cross-sectional surveys, 2010–2016
Abstract Background Dental caries is a localized deterioration of hard tissues caused by acidic by-products of bacterial fermentation of dietary carbohydrates. However, except for fluoride, there were few studies focusing on the direct association between other trace elements. This study aimed to ex...
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2025-03-01
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| Online Access: | https://doi.org/10.1186/s12903-025-05763-3 |
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| author | Taowu Chen Yulin Chen Heng Wang Xueqing Li Xin Guo Hong Tan Xiaoyan Zhang Chunhui Li Rui Shi Chen Sun |
| author_facet | Taowu Chen Yulin Chen Heng Wang Xueqing Li Xin Guo Hong Tan Xiaoyan Zhang Chunhui Li Rui Shi Chen Sun |
| author_sort | Taowu Chen |
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| description | Abstract Background Dental caries is a localized deterioration of hard tissues caused by acidic by-products of bacterial fermentation of dietary carbohydrates. However, except for fluoride, there were few studies focusing on the direct association between other trace elements. This study aimed to explore how other trace elements affect dental caries. Methods Data from 10,426 individuals were collected from the National Health and Nutrition Examination Survey (NHANES) during the 2010–2016 cycle. The sample was restricted to individuals aged 20 years or older who had complete clinical oral examination data, and who had also completed blood (N = 10,086), serum (N = 5,152), or urine tests (N = 5,297). These three groups were weighted to represent multi-year data. The effects of 20 trace elements on dental caries experience were investigated using quartiles of continuous variables and weighted multivariate logistic regression models. Results The analysis revealed significant differences in trace elements (lead, cadmium, mercury, molybdenum, tin, and tungsten) between individuals with no dental caries experience and those with dental caries experience (P < 0.05). Adjusted results from the weighted multivariate logistic regression model showed that the odds ratios (OR) for following trace elements were significantly positively associated with dental caries experience: lead (OR = 1.0105; 95% CI 1.0030–1.0181; P = 0.0077), cobalt (OR = 1.0048; 95% CI 1.001–1.0087; P = 0.0154), cesium (OR = 1.0028; 95% CI 1.0011–1.0046; P = 0.0027), and arsenic (OR = 1.0002; 95% CI 1-1.0004; P = 0.0244), while iron (OR = 0.9974; 95% CI 0.9954–0.9994; P = 0.0116) showed the negative association. Conclusion The results of this cross-sectional study conducted on the U.S. population identified a statistically significant positive association between dental caries and trace elements, including lead, cobalt, cesium, and arsenic, while a negative association was observed with iron. |
| format | Article |
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| institution | DOAJ |
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| language | English |
| publishDate | 2025-03-01 |
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| series | BMC Oral Health |
| spelling | doaj-art-64d88fa390724c9faa934327cb7ca29b2025-08-20T02:40:43ZengBMCBMC Oral Health1472-68312025-03-0125111110.1186/s12903-025-05763-3Association between trace elements and dental caries in the USA: analysis of data from serial cross-sectional surveys, 2010–2016Taowu Chen0Yulin Chen1Heng Wang2Xueqing Li3Xin Guo4Hong Tan5Xiaoyan Zhang6Chunhui Li7Rui Shi8Chen Sun9Department of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityDepartment of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical UniversityAbstract Background Dental caries is a localized deterioration of hard tissues caused by acidic by-products of bacterial fermentation of dietary carbohydrates. However, except for fluoride, there were few studies focusing on the direct association between other trace elements. This study aimed to explore how other trace elements affect dental caries. Methods Data from 10,426 individuals were collected from the National Health and Nutrition Examination Survey (NHANES) during the 2010–2016 cycle. The sample was restricted to individuals aged 20 years or older who had complete clinical oral examination data, and who had also completed blood (N = 10,086), serum (N = 5,152), or urine tests (N = 5,297). These three groups were weighted to represent multi-year data. The effects of 20 trace elements on dental caries experience were investigated using quartiles of continuous variables and weighted multivariate logistic regression models. Results The analysis revealed significant differences in trace elements (lead, cadmium, mercury, molybdenum, tin, and tungsten) between individuals with no dental caries experience and those with dental caries experience (P < 0.05). Adjusted results from the weighted multivariate logistic regression model showed that the odds ratios (OR) for following trace elements were significantly positively associated with dental caries experience: lead (OR = 1.0105; 95% CI 1.0030–1.0181; P = 0.0077), cobalt (OR = 1.0048; 95% CI 1.001–1.0087; P = 0.0154), cesium (OR = 1.0028; 95% CI 1.0011–1.0046; P = 0.0027), and arsenic (OR = 1.0002; 95% CI 1-1.0004; P = 0.0244), while iron (OR = 0.9974; 95% CI 0.9954–0.9994; P = 0.0116) showed the negative association. Conclusion The results of this cross-sectional study conducted on the U.S. population identified a statistically significant positive association between dental caries and trace elements, including lead, cobalt, cesium, and arsenic, while a negative association was observed with iron.https://doi.org/10.1186/s12903-025-05763-3Dental cariesTrace elementNHANESBloodUrineSerum |
| spellingShingle | Taowu Chen Yulin Chen Heng Wang Xueqing Li Xin Guo Hong Tan Xiaoyan Zhang Chunhui Li Rui Shi Chen Sun Association between trace elements and dental caries in the USA: analysis of data from serial cross-sectional surveys, 2010–2016 BMC Oral Health Dental caries Trace element NHANES Blood Urine Serum |
| title | Association between trace elements and dental caries in the USA: analysis of data from serial cross-sectional surveys, 2010–2016 |
| title_full | Association between trace elements and dental caries in the USA: analysis of data from serial cross-sectional surveys, 2010–2016 |
| title_fullStr | Association between trace elements and dental caries in the USA: analysis of data from serial cross-sectional surveys, 2010–2016 |
| title_full_unstemmed | Association between trace elements and dental caries in the USA: analysis of data from serial cross-sectional surveys, 2010–2016 |
| title_short | Association between trace elements and dental caries in the USA: analysis of data from serial cross-sectional surveys, 2010–2016 |
| title_sort | association between trace elements and dental caries in the usa analysis of data from serial cross sectional surveys 2010 2016 |
| topic | Dental caries Trace element NHANES Blood Urine Serum |
| url | https://doi.org/10.1186/s12903-025-05763-3 |
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