Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study
Background. Prostate cancer (PCa) racial disparity is multifactorial, involving biological, sociocultural, and lifestyle determinants. We investigated the association between selected potentially functional polymorphisms (SNPs) and prostate cancer (PCa) risk in Black (AAM) and White (EAM) men. We fu...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/384594 |
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| author | Ganna Chornokur Ernest K. Amankwah Stacy N. Davis Catherine M. Phelan Jong Y. Park Julio Pow-Sang Nagi B. Kumar |
| author_facet | Ganna Chornokur Ernest K. Amankwah Stacy N. Davis Catherine M. Phelan Jong Y. Park Julio Pow-Sang Nagi B. Kumar |
| author_sort | Ganna Chornokur |
| collection | DOAJ |
| description | Background. Prostate cancer (PCa) racial disparity is multifactorial, involving biological, sociocultural, and lifestyle determinants. We investigated the association between selected potentially functional polymorphisms (SNPs) and prostate cancer (PCa) risk in Black (AAM) and White (EAM) men. We further explored if these associations varied by the body mass index (BMI) and height. Methods. Age-matched DNA samples from 259 AAM and 269 EAM were genotyped for 10 candidate SNPs in 7 genes using the TaqMan allelic differentiation analysis. The dominant, recessive, and additive age-adjusted unconditional logistic regression models were fitted. Results. Three SNPs showed statistically significant associations with PCa risk: in AAM, HNF1B rs7501939 (OR=2.42, P=0.0046) and rs4430796 (OR=0.57, P=0.0383); in EAM, CTBP2 rs4962416 (OR=1.52, P=0.0384). In addition, high BMI in AAM (OR=1.06, P=0.022) and height in EAM (OR=0.92, P=0.0434) showed significant associations. Interestingly, HNF1B rs7501939 was associated with PCa exclusively in obese AAM (OR=2.14, P=0.0103). Conclusion. Our results suggest that variation in the HNF1B may influence PCa risk in obese AAM. |
| format | Article |
| id | doaj-art-64d1cbcc5dca4b318aef8ad96b1babf6 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-64d1cbcc5dca4b318aef8ad96b1babf62025-08-20T03:34:36ZengWileyProstate Cancer2090-31112090-312X2013-01-01201310.1155/2013/384594384594Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot StudyGanna Chornokur0Ernest K. Amankwah1Stacy N. Davis2Catherine M. Phelan3Jong Y. Park4Julio Pow-Sang5Nagi B. Kumar6Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USABackground. Prostate cancer (PCa) racial disparity is multifactorial, involving biological, sociocultural, and lifestyle determinants. We investigated the association between selected potentially functional polymorphisms (SNPs) and prostate cancer (PCa) risk in Black (AAM) and White (EAM) men. We further explored if these associations varied by the body mass index (BMI) and height. Methods. Age-matched DNA samples from 259 AAM and 269 EAM were genotyped for 10 candidate SNPs in 7 genes using the TaqMan allelic differentiation analysis. The dominant, recessive, and additive age-adjusted unconditional logistic regression models were fitted. Results. Three SNPs showed statistically significant associations with PCa risk: in AAM, HNF1B rs7501939 (OR=2.42, P=0.0046) and rs4430796 (OR=0.57, P=0.0383); in EAM, CTBP2 rs4962416 (OR=1.52, P=0.0384). In addition, high BMI in AAM (OR=1.06, P=0.022) and height in EAM (OR=0.92, P=0.0434) showed significant associations. Interestingly, HNF1B rs7501939 was associated with PCa exclusively in obese AAM (OR=2.14, P=0.0103). Conclusion. Our results suggest that variation in the HNF1B may influence PCa risk in obese AAM.http://dx.doi.org/10.1155/2013/384594 |
| spellingShingle | Ganna Chornokur Ernest K. Amankwah Stacy N. Davis Catherine M. Phelan Jong Y. Park Julio Pow-Sang Nagi B. Kumar Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study Prostate Cancer |
| title | Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study |
| title_full | Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study |
| title_fullStr | Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study |
| title_full_unstemmed | Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study |
| title_short | Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study |
| title_sort | variation in hnf1b and obesity may influence prostate cancer risk in african american men a pilot study |
| url | http://dx.doi.org/10.1155/2013/384594 |
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