OPTIMAL TREATMENT STRATEGY FOR PATIENTS WITH PROGRESSIVE SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
The treatment of common forms of squamous cell carcinoma of the organs located on the head and neck that are not subject to surgical treatment is limited to the use of chemoradiotherapy with platinum derivatives or drug therapy with platinum-containing regimens. With the progression of the disease,...
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| Format: | Article |
| Language: | Russian |
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QUASAR, LLC
2019-09-01
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| Series: | Исследования и практика в медицине |
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| Online Access: | https://www.rpmj.ru/rpmj/article/view/428 |
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| author | L. V. Bolotina C. A. Kravtsov T. V. Ustinova E. Yu. Karpenko A. L. Kornietskaya A. A. Paichadze V. N. Galkin A. D. Kaprin A. A. Fedenko |
| author_facet | L. V. Bolotina C. A. Kravtsov T. V. Ustinova E. Yu. Karpenko A. L. Kornietskaya A. A. Paichadze V. N. Galkin A. D. Kaprin A. A. Fedenko |
| author_sort | L. V. Bolotina |
| collection | DOAJ |
| description | The treatment of common forms of squamous cell carcinoma of the organs located on the head and neck that are not subject to surgical treatment is limited to the use of chemoradiotherapy with platinum derivatives or drug therapy with platinum-containing regimens. With the progression of the disease, ineffective 2‑line cytostatics were prescribed that did not fundamentally change the course of the tumor process. The introduction into clinical practice of drugs of the original mechanism of action has significantly increased the effectiveness of drug therapy during progression after platinum-containing chemotherapy. The article presents two clinical observations that demonstrate the relevance of the strategy of using inhibitors of immune response control points after platinum preparations. |
| format | Article |
| id | doaj-art-64cbf83a3fde431e8bbcc0c847ec9a0e |
| institution | Kabale University |
| issn | 2410-1893 |
| language | Russian |
| publishDate | 2019-09-01 |
| publisher | QUASAR, LLC |
| record_format | Article |
| series | Исследования и практика в медицине |
| spelling | doaj-art-64cbf83a3fde431e8bbcc0c847ec9a0e2025-08-20T04:00:14ZrusQUASAR, LLCИсследования и практика в медицине2410-18932019-09-016311512810.17709/2409-2231-2019-6-3-11280OPTIMAL TREATMENT STRATEGY FOR PATIENTS WITH PROGRESSIVE SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECKL. V. Bolotina0C. A. Kravtsov1T. V. Ustinova2E. Yu. Karpenko3A. L. Kornietskaya4A. A. Paichadze5V. N. Galkin6A. D. Kaprin7A. A. Fedenko8P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationCity Clinical Oncology Hospital No. 1, Moscow Department of HealthP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationCity Clinical Oncology Hospital No. 1, Moscow Department of HealthP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationThe treatment of common forms of squamous cell carcinoma of the organs located on the head and neck that are not subject to surgical treatment is limited to the use of chemoradiotherapy with platinum derivatives or drug therapy with platinum-containing regimens. With the progression of the disease, ineffective 2‑line cytostatics were prescribed that did not fundamentally change the course of the tumor process. The introduction into clinical practice of drugs of the original mechanism of action has significantly increased the effectiveness of drug therapy during progression after platinum-containing chemotherapy. The article presents two clinical observations that demonstrate the relevance of the strategy of using inhibitors of immune response control points after platinum preparations.https://www.rpmj.ru/rpmj/article/view/428squamous cell carcinoma of the head and neckplatinum-containing chemotherapyimmuno-oncological drugs2-line drug therapyexpression of pd-l1 |
| spellingShingle | L. V. Bolotina C. A. Kravtsov T. V. Ustinova E. Yu. Karpenko A. L. Kornietskaya A. A. Paichadze V. N. Galkin A. D. Kaprin A. A. Fedenko OPTIMAL TREATMENT STRATEGY FOR PATIENTS WITH PROGRESSIVE SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK Исследования и практика в медицине squamous cell carcinoma of the head and neck platinum-containing chemotherapy immuno-oncological drugs 2-line drug therapy expression of pd-l1 |
| title | OPTIMAL TREATMENT STRATEGY FOR PATIENTS WITH PROGRESSIVE SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK |
| title_full | OPTIMAL TREATMENT STRATEGY FOR PATIENTS WITH PROGRESSIVE SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK |
| title_fullStr | OPTIMAL TREATMENT STRATEGY FOR PATIENTS WITH PROGRESSIVE SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK |
| title_full_unstemmed | OPTIMAL TREATMENT STRATEGY FOR PATIENTS WITH PROGRESSIVE SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK |
| title_short | OPTIMAL TREATMENT STRATEGY FOR PATIENTS WITH PROGRESSIVE SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK |
| title_sort | optimal treatment strategy for patients with progressive squamous cell carcinoma of the head and neck |
| topic | squamous cell carcinoma of the head and neck platinum-containing chemotherapy immuno-oncological drugs 2-line drug therapy expression of pd-l1 |
| url | https://www.rpmj.ru/rpmj/article/view/428 |
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