Lipopolysaccharide preconditioning augments the antibacterial activity of renal macrophages and ameliorates acute kidney injury caused by bacteremia in mice

Lipopolysaccharide preconditioning augments the antibacterial activity of renal macrophages and ameliorates acute kidney injury caused by bacteremia in mice

Introduction Repeated injections of low-dose lipopolysaccharide (LPS preconditioning) augment the antibacterial activity of liver macrophages. In this study, a mouse model of acute kidney injury (AKI) induced by Staphylococcus aureus (S. aureus) bacteremia was used to investigate the effects of LPS...

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Main Authors: Keiko Tanoue, Manabu Kinoshita, Bradley M Kearney, Seigo Ito, Hiroyasu Goto, Aoi Yamashiro, Tsugumi Fukunaga, Hiroki Sato, Kazuma Mori, Koji Kuwata, Hidehito Matsubara, Azusa Kato, Masahiro Nakashima, Hiroyuki Nakashima, Toshihiko Imakiire, Naoki Oshima
Format: Article
Language:English
Published: SAGE Publishing 2025-04-01
Series:Innate Immunity
Online Access:https://doi.org/10.1177/17534259251335770
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