Association between Metabolic Syndrome and Its Components with Cardiovascular Disease Risk in the MASHAD Cohort Study Population
Introduction: The primary aim of this study was to evaluate the association of metabolic syndrome (MetS), based on different definitions, with the risk of total cardiovascular disease (CVD), unstable angina (UA), stable angina (SA), and myocardial infarction (MI). Additionally, we aimed to investiga...
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Mashhad University of Medical Sciences
2025-03-01
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| Series: | Journal of Cardio-Thoracic Medicine |
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| author | Zahra Asadi Hamideh Ghazizadeh Ameneh Timar Mohammad Amin Khodadadegan Hamed Ghazavi Mohammad Nasrabadi Toktam Sahranavard Mohammad Reza Fazl Mashhadi Mohammad Amin Mohammadi Arezoo Rastegar-Moghadam Ali Ebrahimi Dabagh Sara Moazedi Shadi Kadkhoda-Ahmadi Mohammad Reza Shadmand Foumani Moghadam Mohanna Zakariaei-Saraji Reza Zare-Feyzabadi Fatemeh Sadabadi Susan Darroudi Afsane Bahrami Habibollah Esmaily Roshanak Ghaffarian Zirak maryam Tayefi Mohsen Moohebati Alireza Heidari Bakavoli Gordon A. Ferns Majid Ghayour-Mobarhan |
| author_facet | Zahra Asadi Hamideh Ghazizadeh Ameneh Timar Mohammad Amin Khodadadegan Hamed Ghazavi Mohammad Nasrabadi Toktam Sahranavard Mohammad Reza Fazl Mashhadi Mohammad Amin Mohammadi Arezoo Rastegar-Moghadam Ali Ebrahimi Dabagh Sara Moazedi Shadi Kadkhoda-Ahmadi Mohammad Reza Shadmand Foumani Moghadam Mohanna Zakariaei-Saraji Reza Zare-Feyzabadi Fatemeh Sadabadi Susan Darroudi Afsane Bahrami Habibollah Esmaily Roshanak Ghaffarian Zirak maryam Tayefi Mohsen Moohebati Alireza Heidari Bakavoli Gordon A. Ferns Majid Ghayour-Mobarhan |
| author_sort | Zahra Asadi |
| collection | DOAJ |
| description | Introduction: The primary aim of this study was to evaluate the association of metabolic syndrome (MetS), based on different definitions, with the risk of total cardiovascular disease (CVD), unstable angina (UA), stable angina (SA), and myocardial infarction (MI). Additionally, we aimed to investigate which definition of MetS is a better predictor of CVD events in a large sample of Iranian adults.Methods: The analysis was conducted among 7,910 adults from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study. The presence of MetS at baseline was defined using the following criteria: International Diabetes Federation (IDF 2005), National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), and World Health Organization (WHO). Hazard ratios (HR) and 95% confidence intervals (CI) were used to estimate the association of MetS and its components with CVD events.Results: The prevalence of MetS among CVD patients was 56.40%, 52.30%, and 23.90% based on the IDF, NCEP ATP III, and WHO criteria, respectively. The highest HR for total CVD (HR: 2.29; 95% CI: 1.54–3.40; P<0.001), UA (HR: 2.13; 95% CI: 1.22 – 3.72; P<0.01), and MI (HR: 3.11; 95% CI: 1.33–7.26; P<0.01) was found when using the WHO definition. The highest HR for SA (HR: 2.56; 95% CI: 1.37 – 4.81; P<0.001) was found when using the NCEP ATP III definition.Conclusion: Having MetS based on the WHO definition was a significant predictor for the incidence of total CVD, MI, and UA, while having MetS based on the ATP III criteria was associated with a higher risk of SA in the MASHAD study population. |
| format | Article |
| id | doaj-art-64c9e081a76c4fb1a9c83a3eb5ebfaa8 |
| institution | DOAJ |
| issn | 2345-2447 2322-5750 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardio-Thoracic Medicine |
| spelling | doaj-art-64c9e081a76c4fb1a9c83a3eb5ebfaa82025-08-20T03:17:14ZengMashhad University of Medical SciencesJournal of Cardio-Thoracic Medicine2345-24472322-57502025-03-011311462147510.22038/jctm.2025.70808.141625753Association between Metabolic Syndrome and Its Components with Cardiovascular Disease Risk in the MASHAD Cohort Study PopulationZahra Asadi0Hamideh Ghazizadeh1Ameneh Timar2Mohammad Amin Khodadadegan3Hamed Ghazavi4Mohammad Nasrabadi5Toktam Sahranavard6Mohammad Reza Fazl Mashhadi7Mohammad Amin Mohammadi8Arezoo Rastegar-Moghadam9Ali Ebrahimi Dabagh10Sara Moazedi11Shadi Kadkhoda-Ahmadi12Mohammad Reza Shadmand Foumani Moghadam13Mohanna Zakariaei-Saraji14Reza Zare-Feyzabadi15Fatemeh Sadabadi16Susan Darroudi17Afsane Bahrami18Habibollah Esmaily19Roshanak Ghaffarian Zirak20maryam Tayefi21Mohsen Moohebati22Alireza Heidari Bakavoli23Gordon A. Ferns24Majid Ghayour-Mobarhan25Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, P.O.Box:397, Sabzevar, Iran.Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.Introduction: The primary aim of this study was to evaluate the association of metabolic syndrome (MetS), based on different definitions, with the risk of total cardiovascular disease (CVD), unstable angina (UA), stable angina (SA), and myocardial infarction (MI). Additionally, we aimed to investigate which definition of MetS is a better predictor of CVD events in a large sample of Iranian adults.Methods: The analysis was conducted among 7,910 adults from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study. The presence of MetS at baseline was defined using the following criteria: International Diabetes Federation (IDF 2005), National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), and World Health Organization (WHO). Hazard ratios (HR) and 95% confidence intervals (CI) were used to estimate the association of MetS and its components with CVD events.Results: The prevalence of MetS among CVD patients was 56.40%, 52.30%, and 23.90% based on the IDF, NCEP ATP III, and WHO criteria, respectively. The highest HR for total CVD (HR: 2.29; 95% CI: 1.54–3.40; P<0.001), UA (HR: 2.13; 95% CI: 1.22 – 3.72; P<0.01), and MI (HR: 3.11; 95% CI: 1.33–7.26; P<0.01) was found when using the WHO definition. The highest HR for SA (HR: 2.56; 95% CI: 1.37 – 4.81; P<0.001) was found when using the NCEP ATP III definition.Conclusion: Having MetS based on the WHO definition was a significant predictor for the incidence of total CVD, MI, and UA, while having MetS based on the ATP III criteria was associated with a higher risk of SA in the MASHAD study population.https://jctm.mums.ac.ir/article_25753_780058fa216bce6b54bf1be2c4631eb3.pdfcardiovascular diseasesinternational diabetes federationmetabolic syndromenational cholesterol education program adult treatment panel iiiworld health organization |
| spellingShingle | Zahra Asadi Hamideh Ghazizadeh Ameneh Timar Mohammad Amin Khodadadegan Hamed Ghazavi Mohammad Nasrabadi Toktam Sahranavard Mohammad Reza Fazl Mashhadi Mohammad Amin Mohammadi Arezoo Rastegar-Moghadam Ali Ebrahimi Dabagh Sara Moazedi Shadi Kadkhoda-Ahmadi Mohammad Reza Shadmand Foumani Moghadam Mohanna Zakariaei-Saraji Reza Zare-Feyzabadi Fatemeh Sadabadi Susan Darroudi Afsane Bahrami Habibollah Esmaily Roshanak Ghaffarian Zirak maryam Tayefi Mohsen Moohebati Alireza Heidari Bakavoli Gordon A. Ferns Majid Ghayour-Mobarhan Association between Metabolic Syndrome and Its Components with Cardiovascular Disease Risk in the MASHAD Cohort Study Population Journal of Cardio-Thoracic Medicine cardiovascular diseases international diabetes federation metabolic syndrome national cholesterol education program adult treatment panel iii world health organization |
| title | Association between Metabolic Syndrome and Its Components with Cardiovascular Disease Risk in the MASHAD Cohort Study Population |
| title_full | Association between Metabolic Syndrome and Its Components with Cardiovascular Disease Risk in the MASHAD Cohort Study Population |
| title_fullStr | Association between Metabolic Syndrome and Its Components with Cardiovascular Disease Risk in the MASHAD Cohort Study Population |
| title_full_unstemmed | Association between Metabolic Syndrome and Its Components with Cardiovascular Disease Risk in the MASHAD Cohort Study Population |
| title_short | Association between Metabolic Syndrome and Its Components with Cardiovascular Disease Risk in the MASHAD Cohort Study Population |
| title_sort | association between metabolic syndrome and its components with cardiovascular disease risk in the mashad cohort study population |
| topic | cardiovascular diseases international diabetes federation metabolic syndrome national cholesterol education program adult treatment panel iii world health organization |
| url | https://jctm.mums.ac.ir/article_25753_780058fa216bce6b54bf1be2c4631eb3.pdf |
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