Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma
Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and a poor prognosis. The blood-brain barrier (BBB) and the blood-tumor barrier (BTB) present significant obstacles to the efficacy of tumor-targeted pharmacotherapy, thereby impeding the t...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000018 |
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| author | Bo Sun Rong Li Ning Ji Han Liu Hongxiang Wang Chao Chen Long Bai Jiacan Su Juxiang Chen |
| author_facet | Bo Sun Rong Li Ning Ji Han Liu Hongxiang Wang Chao Chen Long Bai Jiacan Su Juxiang Chen |
| author_sort | Bo Sun |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and a poor prognosis. The blood-brain barrier (BBB) and the blood-tumor barrier (BTB) present significant obstacles to the efficacy of tumor-targeted pharmacotherapy, thereby impeding the therapeutic potential of numerous candidate drugs. Targeting delivery of adequate doses of drug across the BBB to treat GBM has become a prominent research area in recent years. This emphasis has driven the exploration and evaluation of diverse technologies for GBM pharmacotherapy, with some already undergoing clinical trials. This review provides a thorough overview of recent advancements and challenges in targeted drug delivery for GBM treatment. It specifically emphasizes systemic drug administration strategies to assess their potential and limitations in GBM treatment. Furthermore, this review highlights promising future research directions in the development of intelligent drug delivery systems aimed at overcoming current challenges and enhancing therapeutic efficacy against GBM. These advancements not only support foundational research on targeted drug delivery systems for GBM but also offer methodological approaches for future clinical applications. |
| format | Article |
| id | doaj-art-64c88e4be35f4b96aa51034fd8d2b869 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-64c88e4be35f4b96aa51034fd8d2b8692025-01-17T04:52:15ZengElsevierMaterials Today Bio2590-00642025-02-0130101443Brain-targeting drug delivery systems: The state of the art in treatment of glioblastomaBo Sun0Rong Li1Ning Ji2Han Liu3Hongxiang Wang4Chao Chen5Long Bai6Jiacan Su7Juxiang Chen8Department of Neurosurgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, ChinaDepartment of Neurosurgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, ChinaDepartment of Neurosurgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China; Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Trauma Orthopedics Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Musculoskeletal Injury and Translational Medicine of Organoids, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine SHU Branch, Shanghai University, Shanghai, 200444, ChinaDepartment of Neurosurgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China; Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Trauma Orthopedics Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Musculoskeletal Injury and Translational Medicine of Organoids, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine SHU Branch, Shanghai University, Shanghai, 200444, ChinaDepartment of Neurosurgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, ChinaDepartment of Neurosurgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, ChinaCorresponding author.; Department of Neurosurgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China; Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Trauma Orthopedics Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Musculoskeletal Injury and Translational Medicine of Organoids, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine SHU Branch, Shanghai University, Shanghai, 200444, ChinaDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Corresponding author. Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.Department of Neurosurgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China; Corresponding author.Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and a poor prognosis. The blood-brain barrier (BBB) and the blood-tumor barrier (BTB) present significant obstacles to the efficacy of tumor-targeted pharmacotherapy, thereby impeding the therapeutic potential of numerous candidate drugs. Targeting delivery of adequate doses of drug across the BBB to treat GBM has become a prominent research area in recent years. This emphasis has driven the exploration and evaluation of diverse technologies for GBM pharmacotherapy, with some already undergoing clinical trials. This review provides a thorough overview of recent advancements and challenges in targeted drug delivery for GBM treatment. It specifically emphasizes systemic drug administration strategies to assess their potential and limitations in GBM treatment. Furthermore, this review highlights promising future research directions in the development of intelligent drug delivery systems aimed at overcoming current challenges and enhancing therapeutic efficacy against GBM. These advancements not only support foundational research on targeted drug delivery systems for GBM but also offer methodological approaches for future clinical applications.http://www.sciencedirect.com/science/article/pii/S2590006425000018GlioblastomaBlood brain barrierBlood-tumor barrierBrain targeting drug delivery systemNanoparticles |
| spellingShingle | Bo Sun Rong Li Ning Ji Han Liu Hongxiang Wang Chao Chen Long Bai Jiacan Su Juxiang Chen Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma Materials Today Bio Glioblastoma Blood brain barrier Blood-tumor barrier Brain targeting drug delivery system Nanoparticles |
| title | Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma |
| title_full | Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma |
| title_fullStr | Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma |
| title_full_unstemmed | Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma |
| title_short | Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma |
| title_sort | brain targeting drug delivery systems the state of the art in treatment of glioblastoma |
| topic | Glioblastoma Blood brain barrier Blood-tumor barrier Brain targeting drug delivery system Nanoparticles |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000018 |
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