Breathing new life nanomedicines for pulmonary drug delivery: targeting approaches, experimental models, and regulatory aspects
Abstract Background The lungs serve a critical function in air transport and gas exchange, presenting an appealing route for noninvasive drug administration. However, the unique physiology and anatomy of the lungs influence the efficacy and safety of pulmonary drug delivery. A comprehensive approach...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-06-01
|
| Series: | Beni-Suef University Journal of Basic and Applied Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43088-025-00646-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849334612759674880 |
|---|---|
| author | Amol Gholap Sagar Pardeshi Prabhanjan Giram Sopan Nangare Shrushti Sodha Harshad Kapare Mahesh More Yogesh Sonar Rahul Shukla Jitendra Naik Gayathri Reddy Fouad Damiri Namdev Dhas Mohammed Berrada Dipak Bari Bhupendra Prajapati Mónica C. García Chandrakantsing Pardeshi |
| author_facet | Amol Gholap Sagar Pardeshi Prabhanjan Giram Sopan Nangare Shrushti Sodha Harshad Kapare Mahesh More Yogesh Sonar Rahul Shukla Jitendra Naik Gayathri Reddy Fouad Damiri Namdev Dhas Mohammed Berrada Dipak Bari Bhupendra Prajapati Mónica C. García Chandrakantsing Pardeshi |
| author_sort | Amol Gholap |
| collection | DOAJ |
| description | Abstract Background The lungs serve a critical function in air transport and gas exchange, presenting an appealing route for noninvasive drug administration. However, the unique physiology and anatomy of the lungs influence the efficacy and safety of pulmonary drug delivery. A comprehensive approach combining both an optimized pharmaceutical formulation and an appropriate delivery device is essential for effective pulmonary therapies. Main body Pulmonary drug delivery can achieve both local and systemic effects. During pulmonary drug delivery, several factors viz. particle size, electrostatic charge, inhalation parameters, airway functionality, disease state, and proper use of delivery device must be considered. Current advancements in nanotechnology have led to the development of innovative nanocarriers tailored for pulmonary administration. These nanocarriers offer benefits such as targeted deposition in specific areas of the tracheobronchial tree, controlled drug release, protection of active pharmaceutical ingredients (APIs) from lung clearance mechanisms, and cell-specific targeting. Research on nanomedicine for pulmonary delivery has progressed significantly, resulting in the development of several (nano)formulations, devices, and products in various stages of clinical development, with some already commercially available. Recent studies have focused on improving inhalation device testing, aerosol formulation development, and the application of in vitro, ex vivo, in vivo, and in silico models to better understand pulmonary drug deposition and disposition. Conclusion This review highlights the anatomical and physiological features of the lungs, recent advances in nanocarrier design and inhalation technologies. In addition, the applications in respiratory and systemic disease management have also been included. While significant progress has been made, challenges remain in optimizing pulmonary drug delivery systems, necessitating further research to address these complexities and enhance the therapeutic outcomes. |
| format | Article |
| id | doaj-art-64c14120db4a462e9d5ddb6c3764ec3d |
| institution | Kabale University |
| issn | 2314-8543 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Beni-Suef University Journal of Basic and Applied Sciences |
| spelling | doaj-art-64c14120db4a462e9d5ddb6c3764ec3d2025-08-20T03:45:31ZengSpringerOpenBeni-Suef University Journal of Basic and Applied Sciences2314-85432025-06-0114114310.1186/s43088-025-00646-6Breathing new life nanomedicines for pulmonary drug delivery: targeting approaches, experimental models, and regulatory aspectsAmol Gholap0Sagar Pardeshi1Prabhanjan Giram2Sopan Nangare3Shrushti Sodha4Harshad Kapare5Mahesh More6Yogesh Sonar7Rahul Shukla8Jitendra Naik9Gayathri Reddy10Fouad Damiri11Namdev Dhas12Mohammed Berrada13Dipak Bari14Bhupendra Prajapati15Mónica C. García16Chandrakantsing Pardeshi17St John Institute of Pharmacy and ResearchSt John Institute of Pharmacy and ResearchDepartment of Pharmaceutical Sciences, University at Buffalo, State University of New YorkDepartment of Pharmaceutics, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University)University of the SciencesDr. D. Y. Patil Unitech Society’s, Dr. D. Y. Patil Institute of Pharmaceutical Sciences & ResearchSekkeiBio Pvt. Ltd.Department of Pharmaceutics, R. C. Patel Institute of PharmacyDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research-RaebareliUniversity Institute of Chemical Technology, KBC North Maharashtra UniversityDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research-RaebareliLaboratory of Biology and Health, Faculty of Sciences Ben M’Sick, University Hassan II of CasablancaDepartment of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE)Laboratory of Biology and Health, Faculty of Sciences Ben M’Sick, University Hassan II of CasablancaDepartment of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and ResearchShree S. K. Patel College of Pharmaceutical Education & Research, Ganpat UniversityUniversidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Ciencias Farmacéuticas, Ciudad Universitaria, Haya de la Torre and Medina AllendeDepartment of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and ResearchAbstract Background The lungs serve a critical function in air transport and gas exchange, presenting an appealing route for noninvasive drug administration. However, the unique physiology and anatomy of the lungs influence the efficacy and safety of pulmonary drug delivery. A comprehensive approach combining both an optimized pharmaceutical formulation and an appropriate delivery device is essential for effective pulmonary therapies. Main body Pulmonary drug delivery can achieve both local and systemic effects. During pulmonary drug delivery, several factors viz. particle size, electrostatic charge, inhalation parameters, airway functionality, disease state, and proper use of delivery device must be considered. Current advancements in nanotechnology have led to the development of innovative nanocarriers tailored for pulmonary administration. These nanocarriers offer benefits such as targeted deposition in specific areas of the tracheobronchial tree, controlled drug release, protection of active pharmaceutical ingredients (APIs) from lung clearance mechanisms, and cell-specific targeting. Research on nanomedicine for pulmonary delivery has progressed significantly, resulting in the development of several (nano)formulations, devices, and products in various stages of clinical development, with some already commercially available. Recent studies have focused on improving inhalation device testing, aerosol formulation development, and the application of in vitro, ex vivo, in vivo, and in silico models to better understand pulmonary drug deposition and disposition. Conclusion This review highlights the anatomical and physiological features of the lungs, recent advances in nanocarrier design and inhalation technologies. In addition, the applications in respiratory and systemic disease management have also been included. While significant progress has been made, challenges remain in optimizing pulmonary drug delivery systems, necessitating further research to address these complexities and enhance the therapeutic outcomes.https://doi.org/10.1186/s43088-025-00646-6NanomedicinesNebulizersDry powder inhalersPulmonaryDrug deliveryTargeting |
| spellingShingle | Amol Gholap Sagar Pardeshi Prabhanjan Giram Sopan Nangare Shrushti Sodha Harshad Kapare Mahesh More Yogesh Sonar Rahul Shukla Jitendra Naik Gayathri Reddy Fouad Damiri Namdev Dhas Mohammed Berrada Dipak Bari Bhupendra Prajapati Mónica C. García Chandrakantsing Pardeshi Breathing new life nanomedicines for pulmonary drug delivery: targeting approaches, experimental models, and regulatory aspects Beni-Suef University Journal of Basic and Applied Sciences Nanomedicines Nebulizers Dry powder inhalers Pulmonary Drug delivery Targeting |
| title | Breathing new life nanomedicines for pulmonary drug delivery: targeting approaches, experimental models, and regulatory aspects |
| title_full | Breathing new life nanomedicines for pulmonary drug delivery: targeting approaches, experimental models, and regulatory aspects |
| title_fullStr | Breathing new life nanomedicines for pulmonary drug delivery: targeting approaches, experimental models, and regulatory aspects |
| title_full_unstemmed | Breathing new life nanomedicines for pulmonary drug delivery: targeting approaches, experimental models, and regulatory aspects |
| title_short | Breathing new life nanomedicines for pulmonary drug delivery: targeting approaches, experimental models, and regulatory aspects |
| title_sort | breathing new life nanomedicines for pulmonary drug delivery targeting approaches experimental models and regulatory aspects |
| topic | Nanomedicines Nebulizers Dry powder inhalers Pulmonary Drug delivery Targeting |
| url | https://doi.org/10.1186/s43088-025-00646-6 |
| work_keys_str_mv | AT amolgholap breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT sagarpardeshi breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT prabhanjangiram breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT sopannangare breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT shrushtisodha breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT harshadkapare breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT maheshmore breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT yogeshsonar breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT rahulshukla breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT jitendranaik breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT gayathrireddy breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT fouaddamiri breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT namdevdhas breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT mohammedberrada breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT dipakbari breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT bhupendraprajapati breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT monicacgarcia breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects AT chandrakantsingpardeshi breathingnewlifenanomedicinesforpulmonarydrugdeliverytargetingapproachesexperimentalmodelsandregulatoryaspects |