Functionalized oligonucleotides, synthetic catalysts as enzyme mimics
This review describes the chemical rationale behind the modification of deoxyribonucleotides, which are later incorporated through an enzymatic or automated supported process, resulting in the synthesis of functionalized oligonucleotides (FuON). These additional handles (located on the base or the s...
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| Format: | Article |
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Académie des sciences
2024-04-01
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| Series: | Comptes Rendus. Chimie |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.261/ |
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| author | Chardet, Crystalle Serres, Sandra Payrastre, Corinne Escudier, Jean-Marc Gerland, Béatrice |
| author_facet | Chardet, Crystalle Serres, Sandra Payrastre, Corinne Escudier, Jean-Marc Gerland, Béatrice |
| author_sort | Chardet, Crystalle |
| collection | DOAJ |
| description | This review describes the chemical rationale behind the modification of deoxyribonucleotides, which are later incorporated through an enzymatic or automated supported process, resulting in the synthesis of functionalized oligonucleotides (FuON). These additional handles (located on the base or the sugar moiety) were carefully chosen to enhance the rather limited repertoire of DNA to develop FuONs that display enzyme-like properties such as catalysis and recognition. We will exemplify the development of FuON either presenting RNA-cleaving activity or acting as peroxidase or protease mimics and discuss the impact of the introduced modifications. |
| format | Article |
| id | doaj-art-64c0421ed00641a3bef3a6490419290f |
| institution | Kabale University |
| issn | 1878-1543 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-64c0421ed00641a3bef3a6490419290f2025-02-07T13:38:54ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432024-04-0126S310511710.5802/crchim.26110.5802/crchim.261Functionalized oligonucleotides, synthetic catalysts as enzyme mimicsChardet, Crystalle0Serres, Sandra1Payrastre, Corinne2https://orcid.org/0000-0002-4267-0390Escudier, Jean-Marc3https://orcid.org/0000-0001-8850-6441Gerland, Béatrice4https://orcid.org/0000-0003-3063-1893Laboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique, UMR CNRS 5068, Université Paul Sabatier, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, FranceLaboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique, UMR CNRS 5068, Université Paul Sabatier, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, FranceLaboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique, UMR CNRS 5068, Université Paul Sabatier, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, FranceLaboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique, UMR CNRS 5068, Université Paul Sabatier, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, FranceLaboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique, UMR CNRS 5068, Université Paul Sabatier, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, FranceThis review describes the chemical rationale behind the modification of deoxyribonucleotides, which are later incorporated through an enzymatic or automated supported process, resulting in the synthesis of functionalized oligonucleotides (FuON). These additional handles (located on the base or the sugar moiety) were carefully chosen to enhance the rather limited repertoire of DNA to develop FuONs that display enzyme-like properties such as catalysis and recognition. We will exemplify the development of FuON either presenting RNA-cleaving activity or acting as peroxidase or protease mimics and discuss the impact of the introduced modifications.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.261/Functionalized oligonucleotidesEnzyme mimicsChemical modifications |
| spellingShingle | Chardet, Crystalle Serres, Sandra Payrastre, Corinne Escudier, Jean-Marc Gerland, Béatrice Functionalized oligonucleotides, synthetic catalysts as enzyme mimics Comptes Rendus. Chimie Functionalized oligonucleotides Enzyme mimics Chemical modifications |
| title | Functionalized oligonucleotides, synthetic catalysts as enzyme mimics |
| title_full | Functionalized oligonucleotides, synthetic catalysts as enzyme mimics |
| title_fullStr | Functionalized oligonucleotides, synthetic catalysts as enzyme mimics |
| title_full_unstemmed | Functionalized oligonucleotides, synthetic catalysts as enzyme mimics |
| title_short | Functionalized oligonucleotides, synthetic catalysts as enzyme mimics |
| title_sort | functionalized oligonucleotides synthetic catalysts as enzyme mimics |
| topic | Functionalized oligonucleotides Enzyme mimics Chemical modifications |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.261/ |
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