Manipulation of P2X Receptor Activities by Light Stimulation
P2X receptors are involved in amplification of inflammatory responses in peripheral nociceptive fibers and in mediating pain-related signals to the CNS. Control of P2X activation has significant importance in managing unwanted hypersensitive neuron responses. To overcome the limitations of chemical...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/7852168 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849412507064598528 |
|---|---|
| author | Sang Seong Kim |
| author_facet | Sang Seong Kim |
| author_sort | Sang Seong Kim |
| collection | DOAJ |
| description | P2X receptors are involved in amplification of inflammatory responses in peripheral nociceptive fibers and in mediating pain-related signals to the CNS. Control of P2X activation has significant importance in managing unwanted hypersensitive neuron responses. To overcome the limitations of chemical ligand treatment, optical stimulation methods of optogenetics and photoswitching achieve efficient control of P2X activation while allowing specificity at the target site and convenient stimulation by light illumination. There are many potential applications for photosensitive elements, such as improved uncaging methods, photoisomerizable ligands, photoswitches, and gold nanoparticles. Each technique has both advantages and downsides, and techniques are selected according to the purpose of the application. Technical advances not only provide novel approaches to manage inflammation or pain mediated by P2X receptors but also suggest a similar approach for controlling other ion channels. |
| format | Article |
| id | doaj-art-64bc134f2b9e493c95644d6ef7e9281c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-64bc134f2b9e493c95644d6ef7e9281c2025-08-20T03:34:25ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/78521687852168Manipulation of P2X Receptor Activities by Light StimulationSang Seong Kim0Department of Pharmacy, Hanyang University, ERICA Campus, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Gyeonggi-do 426-791, Republic of KoreaP2X receptors are involved in amplification of inflammatory responses in peripheral nociceptive fibers and in mediating pain-related signals to the CNS. Control of P2X activation has significant importance in managing unwanted hypersensitive neuron responses. To overcome the limitations of chemical ligand treatment, optical stimulation methods of optogenetics and photoswitching achieve efficient control of P2X activation while allowing specificity at the target site and convenient stimulation by light illumination. There are many potential applications for photosensitive elements, such as improved uncaging methods, photoisomerizable ligands, photoswitches, and gold nanoparticles. Each technique has both advantages and downsides, and techniques are selected according to the purpose of the application. Technical advances not only provide novel approaches to manage inflammation or pain mediated by P2X receptors but also suggest a similar approach for controlling other ion channels.http://dx.doi.org/10.1155/2016/7852168 |
| spellingShingle | Sang Seong Kim Manipulation of P2X Receptor Activities by Light Stimulation Mediators of Inflammation |
| title | Manipulation of P2X Receptor Activities by Light Stimulation |
| title_full | Manipulation of P2X Receptor Activities by Light Stimulation |
| title_fullStr | Manipulation of P2X Receptor Activities by Light Stimulation |
| title_full_unstemmed | Manipulation of P2X Receptor Activities by Light Stimulation |
| title_short | Manipulation of P2X Receptor Activities by Light Stimulation |
| title_sort | manipulation of p2x receptor activities by light stimulation |
| url | http://dx.doi.org/10.1155/2016/7852168 |
| work_keys_str_mv | AT sangseongkim manipulationofp2xreceptoractivitiesbylightstimulation |