Physiopathology of polycystic ovary syndrome in endocrinology, metabolism and inflammation
Abstract Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by elevated androgen levels, ovarian cysts, and impaired ovulation in females. This condition is closely linked with various reproductive health issues and has significant impacts on endocrine and metabolic pat...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Ovarian Research |
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| Online Access: | https://doi.org/10.1186/s13048-025-01621-6 |
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| _version_ | 1850191158298279936 |
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| author | Pingping Su Chao Chen Yun Sun |
| author_facet | Pingping Su Chao Chen Yun Sun |
| author_sort | Pingping Su |
| collection | DOAJ |
| description | Abstract Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by elevated androgen levels, ovarian cysts, and impaired ovulation in females. This condition is closely linked with various reproductive health issues and has significant impacts on endocrine and metabolic pathways. Patients with PCOS commonly exhibit hyperandrogenaemia and insulin resistance, leading to complications such as acne, hirsutism, weight fluctuations, and metabolic disturbances, as well as an increased risk for type 2 diabetes, cardiovascular disease, and endometrial cancer. Although extensive research has identified several mechanistic aspects of PCOS, a thorough understanding of its pathophysiology remains incomplete. This review aims to provide a detailed analysis of the physiological and pathological aspects of PCOS, covering endocrine, metabolic, and inflammatory dimensions, to better elucidate its etiological framework. |
| format | Article |
| id | doaj-art-64b91aa0afc549f8a05589e720b60edd |
| institution | OA Journals |
| issn | 1757-2215 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj-art-64b91aa0afc549f8a05589e720b60edd2025-08-20T02:15:00ZengBMCJournal of Ovarian Research1757-22152025-02-0118111010.1186/s13048-025-01621-6Physiopathology of polycystic ovary syndrome in endocrinology, metabolism and inflammationPingping Su0Chao Chen1Yun Sun2Wenzhou Graduate Joint Training Base, Zhejiang Chinese Medical UniversityDepartment of Traditional Chinese Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Gynecology, Wenzhou TCM Hospital of Zhejiang Chinese Medical UniversityAbstract Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by elevated androgen levels, ovarian cysts, and impaired ovulation in females. This condition is closely linked with various reproductive health issues and has significant impacts on endocrine and metabolic pathways. Patients with PCOS commonly exhibit hyperandrogenaemia and insulin resistance, leading to complications such as acne, hirsutism, weight fluctuations, and metabolic disturbances, as well as an increased risk for type 2 diabetes, cardiovascular disease, and endometrial cancer. Although extensive research has identified several mechanistic aspects of PCOS, a thorough understanding of its pathophysiology remains incomplete. This review aims to provide a detailed analysis of the physiological and pathological aspects of PCOS, covering endocrine, metabolic, and inflammatory dimensions, to better elucidate its etiological framework.https://doi.org/10.1186/s13048-025-01621-6Polycystic ovary syndromeEndocrinologyMetabolismInflammationPhysiopathology |
| spellingShingle | Pingping Su Chao Chen Yun Sun Physiopathology of polycystic ovary syndrome in endocrinology, metabolism and inflammation Journal of Ovarian Research Polycystic ovary syndrome Endocrinology Metabolism Inflammation Physiopathology |
| title | Physiopathology of polycystic ovary syndrome in endocrinology, metabolism and inflammation |
| title_full | Physiopathology of polycystic ovary syndrome in endocrinology, metabolism and inflammation |
| title_fullStr | Physiopathology of polycystic ovary syndrome in endocrinology, metabolism and inflammation |
| title_full_unstemmed | Physiopathology of polycystic ovary syndrome in endocrinology, metabolism and inflammation |
| title_short | Physiopathology of polycystic ovary syndrome in endocrinology, metabolism and inflammation |
| title_sort | physiopathology of polycystic ovary syndrome in endocrinology metabolism and inflammation |
| topic | Polycystic ovary syndrome Endocrinology Metabolism Inflammation Physiopathology |
| url | https://doi.org/10.1186/s13048-025-01621-6 |
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