Acute Seronegative Toxoplasma gondii Hepatitis Allergic to First-Line Treatment
Toxoplasma gondii infects up to one-third of the world’s population, making it the protozoan that most infects people worldwide. Among the forms of presentation of toxoplasmosis, hepatitis is probably the least frequent with only a few case reports in the world’s medical literature. Despite the fact...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2018/1951936 |
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| author | Fernando De la Garza-Salazar Carlos Alejandro Cortéz-Hernández Horacio Decanini-Arcaute Adrián Camacho-Ortiz |
| author_facet | Fernando De la Garza-Salazar Carlos Alejandro Cortéz-Hernández Horacio Decanini-Arcaute Adrián Camacho-Ortiz |
| author_sort | Fernando De la Garza-Salazar |
| collection | DOAJ |
| description | Toxoplasma gondii infects up to one-third of the world’s population, making it the protozoan that most infects people worldwide. Among the forms of presentation of toxoplasmosis, hepatitis is probably the least frequent with only a few case reports in the world’s medical literature. Despite the fact that the first diagnostic test is the serology using the ELISA technique because its sensitivity is close to 100% in our case, it was reported negative. The biopsy gave the definitive diagnosis, and we were able to start treatment immediately. Although the first line of treatment is sulfadiazine and pyrimethamine, our sulfate allergic patient received an alternative regimen of doxycycline, clindamycin, and azithromycin with a good response. This is the only case of Toxoplasma hepatitis reported in Mexico and the only one in the world with negative serology with a good response to second-line treatment. |
| format | Article |
| id | doaj-art-64b81a4f7ec14d94aa1c31f6b06f2ef5 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-64b81a4f7ec14d94aa1c31f6b06f2ef52025-08-20T03:34:25ZengWileyCase Reports in Infectious Diseases2090-66252090-66332018-01-01201810.1155/2018/19519361951936Acute Seronegative Toxoplasma gondii Hepatitis Allergic to First-Line TreatmentFernando De la Garza-Salazar0Carlos Alejandro Cortéz-Hernández1Horacio Decanini-Arcaute2Adrián Camacho-Ortiz3Department of Internal Medicine, Christus Muguerza Hospital Alta Especialidad, Universidad de Monterrey, San Pedro Garza García, NL 64060, MexicoDepartment of Gastroenterology, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, NL 64460, MexicoDepartment of Pathology, Christus Muguerza Hospital Alta Especialidad, Universidad de Monterrey, San Pedro Garza García, NL 64060, MexicoEpidemiologic Hospital Coordination, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, NL 64460, MexicoToxoplasma gondii infects up to one-third of the world’s population, making it the protozoan that most infects people worldwide. Among the forms of presentation of toxoplasmosis, hepatitis is probably the least frequent with only a few case reports in the world’s medical literature. Despite the fact that the first diagnostic test is the serology using the ELISA technique because its sensitivity is close to 100% in our case, it was reported negative. The biopsy gave the definitive diagnosis, and we were able to start treatment immediately. Although the first line of treatment is sulfadiazine and pyrimethamine, our sulfate allergic patient received an alternative regimen of doxycycline, clindamycin, and azithromycin with a good response. This is the only case of Toxoplasma hepatitis reported in Mexico and the only one in the world with negative serology with a good response to second-line treatment.http://dx.doi.org/10.1155/2018/1951936 |
| spellingShingle | Fernando De la Garza-Salazar Carlos Alejandro Cortéz-Hernández Horacio Decanini-Arcaute Adrián Camacho-Ortiz Acute Seronegative Toxoplasma gondii Hepatitis Allergic to First-Line Treatment Case Reports in Infectious Diseases |
| title | Acute Seronegative Toxoplasma gondii Hepatitis Allergic to First-Line Treatment |
| title_full | Acute Seronegative Toxoplasma gondii Hepatitis Allergic to First-Line Treatment |
| title_fullStr | Acute Seronegative Toxoplasma gondii Hepatitis Allergic to First-Line Treatment |
| title_full_unstemmed | Acute Seronegative Toxoplasma gondii Hepatitis Allergic to First-Line Treatment |
| title_short | Acute Seronegative Toxoplasma gondii Hepatitis Allergic to First-Line Treatment |
| title_sort | acute seronegative toxoplasma gondii hepatitis allergic to first line treatment |
| url | http://dx.doi.org/10.1155/2018/1951936 |
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