Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice

Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice

Abstract Intervertebral disc degeneration is a major risk factor contributing to chronic low back and neck pain. While the etiological factors for disc degeneration vary, age is still one of the most important risk factors. Recent studies have shown the promising role of SIRT6 in mammalian aging and...

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Main Authors: Pranay Ramteke, Bahiyah Watson, Mallory Toci, Victoria A. Tran, Shira Johnston, Maria Tsingas, Ruteja A. Barve, Ramkrishna Mitra, Richard F. Loeser, John A. Collins, Makarand V. Risbud
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-025-00422-3
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