Association between triglyceride-glucose index and hypertension in adults with cancer from NHANES 2005–2018: a cross-sectional study
Abstract Background Insulin resistance (IR) is linked to hypertension development.The triglyceride-glucose (TyG) index is a proposed alternative biochemical marker for IR. This study aimed to explore the relationship between TyG and hypertension in adults with cancer. Methods A cross-sectional study...
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2025-06-01
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| Online Access: | https://doi.org/10.1186/s12885-025-14398-0 |
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| author | Gangping Li Di Zhang Minghui Li Fangfang Yuan Yongqi Wang Yuewen Fu |
| author_facet | Gangping Li Di Zhang Minghui Li Fangfang Yuan Yongqi Wang Yuewen Fu |
| author_sort | Gangping Li |
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| description | Abstract Background Insulin resistance (IR) is linked to hypertension development.The triglyceride-glucose (TyG) index is a proposed alternative biochemical marker for IR. This study aimed to explore the relationship between TyG and hypertension in adults with cancer. Methods A cross-sectional study was conducted involving 1,222 cancer adults patients from the NHANES dataset (2005–2018). Demographics, medical history, lifestyle factors, and lab tests were assessed. Multivariable logistic regression, subgroup analysis, and smooth curve-fitting techniques were used. Results Among 1,222 eligible participants, 775 (56.29%) had hypertension. When TyG was assessed as a continuous variable, higher TyG levels were significantly associated with increased hypertension prevalence (OR, 1.51; 95% CI, 1.09–2.11; p = 0.015) after adjusting for covariates. When TyG was analyzed as quartiles, compared to individuals with lower TyG Q1 (7.0–8.3), the adjusted OR values for TyG and hypertension in Q2 (8.3–8.7), Q3 (8.7–9.1), and Q4 (9.1–10.7) were 1.32 (95% CI: 0.85–2.06, p = 0.022), 1.63 (95% CI: 1.01–2.64, p = 0.043), and 1.68 (95% CI: 1.09–2.84, p = 0.041), respectively. The data were stratified by age, sex, marital status, education level, and family income. Stratified analysis revealed no significant interactions among subgroups (all p-Values > 0.05). Analysis using restricted cubic splines(RCS) suggested a linear relationship between TyG and hypertension in adults with cancer. Conclusions Higher TyG levels are associated with an increased risk of hypertension in adults with cancer. |
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| publishDate | 2025-06-01 |
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| series | BMC Cancer |
| spelling | doaj-art-64aecdc2e69c44f3abaf943a4409c8c02025-08-20T02:30:42ZengBMCBMC Cancer1471-24072025-06-0125111210.1186/s12885-025-14398-0Association between triglyceride-glucose index and hypertension in adults with cancer from NHANES 2005–2018: a cross-sectional studyGangping Li0Di Zhang1Minghui Li2Fangfang Yuan3Yongqi Wang4Yuewen Fu5Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Medical Records Management Department, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalAbstract Background Insulin resistance (IR) is linked to hypertension development.The triglyceride-glucose (TyG) index is a proposed alternative biochemical marker for IR. This study aimed to explore the relationship between TyG and hypertension in adults with cancer. Methods A cross-sectional study was conducted involving 1,222 cancer adults patients from the NHANES dataset (2005–2018). Demographics, medical history, lifestyle factors, and lab tests were assessed. Multivariable logistic regression, subgroup analysis, and smooth curve-fitting techniques were used. Results Among 1,222 eligible participants, 775 (56.29%) had hypertension. When TyG was assessed as a continuous variable, higher TyG levels were significantly associated with increased hypertension prevalence (OR, 1.51; 95% CI, 1.09–2.11; p = 0.015) after adjusting for covariates. When TyG was analyzed as quartiles, compared to individuals with lower TyG Q1 (7.0–8.3), the adjusted OR values for TyG and hypertension in Q2 (8.3–8.7), Q3 (8.7–9.1), and Q4 (9.1–10.7) were 1.32 (95% CI: 0.85–2.06, p = 0.022), 1.63 (95% CI: 1.01–2.64, p = 0.043), and 1.68 (95% CI: 1.09–2.84, p = 0.041), respectively. The data were stratified by age, sex, marital status, education level, and family income. Stratified analysis revealed no significant interactions among subgroups (all p-Values > 0.05). Analysis using restricted cubic splines(RCS) suggested a linear relationship between TyG and hypertension in adults with cancer. Conclusions Higher TyG levels are associated with an increased risk of hypertension in adults with cancer.https://doi.org/10.1186/s12885-025-14398-0Triglyceride-glucoseindexHypertensionNHANESCancerCross- sectional study |
| spellingShingle | Gangping Li Di Zhang Minghui Li Fangfang Yuan Yongqi Wang Yuewen Fu Association between triglyceride-glucose index and hypertension in adults with cancer from NHANES 2005–2018: a cross-sectional study BMC Cancer Triglyceride-glucoseindex Hypertension NHANES Cancer Cross- sectional study |
| title | Association between triglyceride-glucose index and hypertension in adults with cancer from NHANES 2005–2018: a cross-sectional study |
| title_full | Association between triglyceride-glucose index and hypertension in adults with cancer from NHANES 2005–2018: a cross-sectional study |
| title_fullStr | Association between triglyceride-glucose index and hypertension in adults with cancer from NHANES 2005–2018: a cross-sectional study |
| title_full_unstemmed | Association between triglyceride-glucose index and hypertension in adults with cancer from NHANES 2005–2018: a cross-sectional study |
| title_short | Association between triglyceride-glucose index and hypertension in adults with cancer from NHANES 2005–2018: a cross-sectional study |
| title_sort | association between triglyceride glucose index and hypertension in adults with cancer from nhanes 2005 2018 a cross sectional study |
| topic | Triglyceride-glucoseindex Hypertension NHANES Cancer Cross- sectional study |
| url | https://doi.org/10.1186/s12885-025-14398-0 |
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