Phytoestrogens Enhance the Vascular Actions of the Endocannabinoid Anandamide in Mesenteric Beds of Female Rats
In rat isolated mesenteric beds that were contracted with NA as an in vitro model of the vascular adrenergic hyperactivity that usually precedes the onset of primary hypertension, the oral administration (3 daily doses) of either 10 mg/kg genistein or 20 mg/kg daidzein potentiated the anandamide-ind...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/647856 |
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| author | Roxana N. Peroni Tamara Abramoff Isabel Neuman Ernesto J. Podestá Edda Adler-Graschinsky |
| author_facet | Roxana N. Peroni Tamara Abramoff Isabel Neuman Ernesto J. Podestá Edda Adler-Graschinsky |
| author_sort | Roxana N. Peroni |
| collection | DOAJ |
| description | In rat isolated mesenteric beds that were contracted with NA as an in vitro model of the vascular adrenergic hyperactivity that usually precedes the onset of primary hypertension, the oral administration (3 daily doses) of either 10 mg/kg genistein or 20 mg/kg daidzein potentiated the anandamide-induced reduction of contractility to NA in female but not in male rats. Oral treatment with phytoestrogens also restored the vascular effects of anandamide as well as the mesenteric content of calcitonin gene-related peptide (CGRP) that were reduced after ovariectomy. The enhancement of anandamide effects caused by phytoestrogens was prevented by the concomitant administration of the estrogen receptor antagonist fulvestrant (2.5 mg/kg, s.c., 3 daily doses). It is concluded that, in the vasculature of female rats, phytoestrogens produced an estrogen-receptor-dependent enhancement of the anandamide-vascular actions that involves the modulation of CGRP levels and appears to be relevant whenever an adrenergic hyperactivity occurs. |
| format | Article |
| id | doaj-art-64abb39679ee4a40942d02f347fd6792 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-64abb39679ee4a40942d02f347fd67922025-02-03T01:20:59ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/647856647856Phytoestrogens Enhance the Vascular Actions of the Endocannabinoid Anandamide in Mesenteric Beds of Female RatsRoxana N. Peroni0Tamara Abramoff1Isabel Neuman2Ernesto J. Podestá3Edda Adler-Graschinsky4Instituto de Investigaciones Farmacológicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Junín 956, 5° Piso, C1113AAD Buenos Aires, ArgentinaInstituto de Investigaciones Farmacológicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Junín 956, 5° Piso, C1113AAD Buenos Aires, ArgentinaDepartamento de Bioquímica IIMHNO, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 5° Piso C1121ABG Buenos Aires, ArgentinaDepartamento de Bioquímica IIMHNO, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 5° Piso C1121ABG Buenos Aires, ArgentinaInstituto de Investigaciones Farmacológicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Junín 956, 5° Piso, C1113AAD Buenos Aires, ArgentinaIn rat isolated mesenteric beds that were contracted with NA as an in vitro model of the vascular adrenergic hyperactivity that usually precedes the onset of primary hypertension, the oral administration (3 daily doses) of either 10 mg/kg genistein or 20 mg/kg daidzein potentiated the anandamide-induced reduction of contractility to NA in female but not in male rats. Oral treatment with phytoestrogens also restored the vascular effects of anandamide as well as the mesenteric content of calcitonin gene-related peptide (CGRP) that were reduced after ovariectomy. The enhancement of anandamide effects caused by phytoestrogens was prevented by the concomitant administration of the estrogen receptor antagonist fulvestrant (2.5 mg/kg, s.c., 3 daily doses). It is concluded that, in the vasculature of female rats, phytoestrogens produced an estrogen-receptor-dependent enhancement of the anandamide-vascular actions that involves the modulation of CGRP levels and appears to be relevant whenever an adrenergic hyperactivity occurs.http://dx.doi.org/10.1155/2012/647856 |
| spellingShingle | Roxana N. Peroni Tamara Abramoff Isabel Neuman Ernesto J. Podestá Edda Adler-Graschinsky Phytoestrogens Enhance the Vascular Actions of the Endocannabinoid Anandamide in Mesenteric Beds of Female Rats International Journal of Hypertension |
| title | Phytoestrogens Enhance the Vascular Actions of the Endocannabinoid Anandamide in Mesenteric Beds of Female Rats |
| title_full | Phytoestrogens Enhance the Vascular Actions of the Endocannabinoid Anandamide in Mesenteric Beds of Female Rats |
| title_fullStr | Phytoestrogens Enhance the Vascular Actions of the Endocannabinoid Anandamide in Mesenteric Beds of Female Rats |
| title_full_unstemmed | Phytoestrogens Enhance the Vascular Actions of the Endocannabinoid Anandamide in Mesenteric Beds of Female Rats |
| title_short | Phytoestrogens Enhance the Vascular Actions of the Endocannabinoid Anandamide in Mesenteric Beds of Female Rats |
| title_sort | phytoestrogens enhance the vascular actions of the endocannabinoid anandamide in mesenteric beds of female rats |
| url | http://dx.doi.org/10.1155/2012/647856 |
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