Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell (<i>Carya illinoinensis</i>) Residues for Skin-Care Applications
This study investigates the incorporation of melanin extracted from pecan nutshell residues into a polyacrylonitrile (PAN) matrix during the electrospinning of microfiber membranes. Melanin concentrations of 0.5, 2.0, and 5.0% <i>w</i>/<i>w</i> were incorporated to enhance th...
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| Format: | Article |
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MDPI AG
2025-02-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/15/2/44 |
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| author | Michell García-García Jesús Salvador Jaime-Ferrer Fernanda Nayeli Medrano-Lango Elizabeth Quintana-Rodríguez Tonatiu Campos-García Erika Rodríguez-Sevilla Domancar Orona-Tamayo |
| author_facet | Michell García-García Jesús Salvador Jaime-Ferrer Fernanda Nayeli Medrano-Lango Elizabeth Quintana-Rodríguez Tonatiu Campos-García Erika Rodríguez-Sevilla Domancar Orona-Tamayo |
| author_sort | Michell García-García |
| collection | DOAJ |
| description | This study investigates the incorporation of melanin extracted from pecan nutshell residues into a polyacrylonitrile (PAN) matrix during the electrospinning of microfiber membranes. Melanin concentrations of 0.5, 2.0, and 5.0% <i>w</i>/<i>w</i> were incorporated to enhance the physicochemical and biological properties of the fibers. The melanin-loaded PAN fibers exhibited significant antioxidant activity against DPPH and ABTS radicals, with scavenging rates ranging from 46.58% to 62.77% and 41.02% to 82.36%, respectively, while unmodified PAN fibers showed no activity. Furthermore, the melanin-loaded membranes demonstrated antimicrobial effects. The membranes also exhibited an important enzyme inhibition activity against collagenase (37%), hyaluronidase (22%), tyrosinase (36%), and elastase (33%). Molecular docking studies reveal different potential amino acids of the active sites of aging enzymes that interact strongly with melanin pigment, particularly collagenase, followed by hyaluronidase, tyrosinase, and elastase. These results suggest that the novel melanin-loaded PAN membranes possess promising bioactive properties with potential applications in different skin-care applications. |
| format | Article |
| id | doaj-art-64a1cbb8902a42b3bfe777fb98b354f1 |
| institution | DOAJ |
| issn | 2077-0375 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj-art-64a1cbb8902a42b3bfe777fb98b354f12025-08-20T02:45:00ZengMDPI AGMembranes2077-03752025-02-011524410.3390/membranes15020044Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell (<i>Carya illinoinensis</i>) Residues for Skin-Care ApplicationsMichell García-García0Jesús Salvador Jaime-Ferrer1Fernanda Nayeli Medrano-Lango2Elizabeth Quintana-Rodríguez3Tonatiu Campos-García4Erika Rodríguez-Sevilla5Domancar Orona-Tamayo6CIATEC A.C., Centro de Innovación Aplicada en Tecnologías Competitivas, Omega 201, Industrial Delta, León C.P. 37545, Guanajuato, MexicoCIATEC A.C., Centro de Innovación Aplicada en Tecnologías Competitivas, Omega 201, Industrial Delta, León C.P. 37545, Guanajuato, MexicoUnidad Profesional Interdisciplinaria de Ingeniería Campus Guanajuato, Instituto Politécnico Nacional, Av. Mineral de Valenciana 200, Col. Fraccionamiento Industrial Puerto Interior, Silao de la Victoria C.P. 36275, Guanajuato, MexicoCIATEC A.C., Centro de Innovación Aplicada en Tecnologías Competitivas, Omega 201, Industrial Delta, León C.P. 37545, Guanajuato, MexicoCONACYT Research Fellow, CIATEJ. A.C., Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, Av. de los Normalistas No. 800, Colinas de La Normal, Guadalajara C.P. 44270, Jalisco, MexicoCIO. A.C., Centro de Investigaciones en Óptica, Loma del Bosque 105, Lomas del Campestre, León C.P. 37150, Guanajuato, MexicoCIATEC A.C., Centro de Innovación Aplicada en Tecnologías Competitivas, Omega 201, Industrial Delta, León C.P. 37545, Guanajuato, MexicoThis study investigates the incorporation of melanin extracted from pecan nutshell residues into a polyacrylonitrile (PAN) matrix during the electrospinning of microfiber membranes. Melanin concentrations of 0.5, 2.0, and 5.0% <i>w</i>/<i>w</i> were incorporated to enhance the physicochemical and biological properties of the fibers. The melanin-loaded PAN fibers exhibited significant antioxidant activity against DPPH and ABTS radicals, with scavenging rates ranging from 46.58% to 62.77% and 41.02% to 82.36%, respectively, while unmodified PAN fibers showed no activity. Furthermore, the melanin-loaded membranes demonstrated antimicrobial effects. The membranes also exhibited an important enzyme inhibition activity against collagenase (37%), hyaluronidase (22%), tyrosinase (36%), and elastase (33%). Molecular docking studies reveal different potential amino acids of the active sites of aging enzymes that interact strongly with melanin pigment, particularly collagenase, followed by hyaluronidase, tyrosinase, and elastase. These results suggest that the novel melanin-loaded PAN membranes possess promising bioactive properties with potential applications in different skin-care applications.https://www.mdpi.com/2077-0375/15/2/44spinning fibersmolecular dockingbioactive compoundantioxidant activityantimicrobial activityantiaging effect |
| spellingShingle | Michell García-García Jesús Salvador Jaime-Ferrer Fernanda Nayeli Medrano-Lango Elizabeth Quintana-Rodríguez Tonatiu Campos-García Erika Rodríguez-Sevilla Domancar Orona-Tamayo Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell (<i>Carya illinoinensis</i>) Residues for Skin-Care Applications Membranes spinning fibers molecular docking bioactive compound antioxidant activity antimicrobial activity antiaging effect |
| title | Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell (<i>Carya illinoinensis</i>) Residues for Skin-Care Applications |
| title_full | Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell (<i>Carya illinoinensis</i>) Residues for Skin-Care Applications |
| title_fullStr | Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell (<i>Carya illinoinensis</i>) Residues for Skin-Care Applications |
| title_full_unstemmed | Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell (<i>Carya illinoinensis</i>) Residues for Skin-Care Applications |
| title_short | Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell (<i>Carya illinoinensis</i>) Residues for Skin-Care Applications |
| title_sort | electrospun membranes loaded with melanin derived from pecan nutshell i carya illinoinensis i residues for skin care applications |
| topic | spinning fibers molecular docking bioactive compound antioxidant activity antimicrobial activity antiaging effect |
| url | https://www.mdpi.com/2077-0375/15/2/44 |
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