Targeted Prostate Biopsies Overestimate International Society of Urological Pathology Grade Group, Particularly in Smaller Tumors
Compared with systematic biopsy of the prostate, magnetic resonance imaging (MRI)-targeted biopsies are associated with lower rates of upgrading and higher rates of downgrading between biopsy tissue and radical prostatectomy (RP) specimen International Society of Urological Pathology (ISUP) grade gr...
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Elsevier
2025-05-01
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| Series: | European Urology Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666168325000850 |
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| author | Lisa J. Kroon Ivo I. de Vos Charlotte F. Kweldam Monique J. Roobol Geert J.L.H. van Leenders Roderick C.N. van den Bergh |
| author_facet | Lisa J. Kroon Ivo I. de Vos Charlotte F. Kweldam Monique J. Roobol Geert J.L.H. van Leenders Roderick C.N. van den Bergh |
| author_sort | Lisa J. Kroon |
| collection | DOAJ |
| description | Compared with systematic biopsy of the prostate, magnetic resonance imaging (MRI)-targeted biopsies are associated with lower rates of upgrading and higher rates of downgrading between biopsy tissue and radical prostatectomy (RP) specimen International Society of Urological Pathology (ISUP) grade group (GG). Higher rates of downgrading could indicate overtreatment for some patients. We hypothesized that concordance rates between biopsy and RP are different per MRI tumor volume. We conducted an explorative retrospective study to identify the risk factors for downgrading, using RP specimens as the reference standard, in a large regional prostate collaboration. Among 616 patients, pathological concordance was seen in 58% and downgrading in 15%. The risk of downgrading was 18% for tumors of 0–10 mm, 14% for 10–20 mm, and 14% for >20 mm. In a multivariable analysis among patients with targeted biopsy GG ≥2, with covariates including clinical tumor stage, prostate-specific antigen (PSA), maximal MRI index lesion diameter, number of positive target biopsies, and GG at targeted biopsy, the statistically significant predictors for downgrading were PSA, maximum MRI index lesion diameter, and target biopsy GG. A lower risk of downgrading was seen in larger tumors (odds ratio per millimeter 0.95, 95% confidence interval 0.91–1.00, p = 0.033). This study suggests that an overestimation of GG on biopsy is most common in smaller MRI lesions. This information is important in clinical decision-making, mainly in deciding on active surveillance versus active therapy or the indication for additional imaging for cancer staging. Patient summary: In this report, we examined risk factors that could explain why some patients have higher pathological grading at prostate biopsy than on the whole prostate specimen after surgical removal. We found that patients with prostate biopsies that are targeted at small lesions on magnetic resonance imaging and patients who had high biopsy grading had a higher risk of having lower grading of their surgical specimens. |
| format | Article |
| id | doaj-art-649ffbdc96a44a00988de4a2bdc5a1b4 |
| institution | DOAJ |
| issn | 2666-1683 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Urology Open Science |
| spelling | doaj-art-649ffbdc96a44a00988de4a2bdc5a1b42025-08-20T03:14:03ZengElsevierEuropean Urology Open Science2666-16832025-05-017571010.1016/j.euros.2025.02.008Targeted Prostate Biopsies Overestimate International Society of Urological Pathology Grade Group, Particularly in Smaller TumorsLisa J. Kroon0Ivo I. de Vos1Charlotte F. Kweldam2Monique J. Roobol3Geert J.L.H. van Leenders4Roderick C.N. van den Bergh5Department of Pathology, Erasmus MC Cancer Institute, University Medical Centre, Rotterdam, The Netherlands; Department of Urology, Erasmus MC Cancer Institute, University Medical Centre, Rotterdam, The Netherlands; Corresponding author. Department of Pathology and Department of Urology, Erasmus MC Cancer Institute, University Medical Centre, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. Tel. +31107040704.Department of Urology, Erasmus MC Cancer Institute, University Medical Centre, Rotterdam, The NetherlandsDepartment of Pathology, Maasstad Hospital, Rotterdam, The NetherlandsDepartment of Urology, Erasmus MC Cancer Institute, University Medical Centre, Rotterdam, The NetherlandsDepartment of Pathology, Erasmus MC Cancer Institute, University Medical Centre, Rotterdam, The NetherlandsDepartment of Urology, Erasmus MC Cancer Institute, University Medical Centre, Rotterdam, The NetherlandsCompared with systematic biopsy of the prostate, magnetic resonance imaging (MRI)-targeted biopsies are associated with lower rates of upgrading and higher rates of downgrading between biopsy tissue and radical prostatectomy (RP) specimen International Society of Urological Pathology (ISUP) grade group (GG). Higher rates of downgrading could indicate overtreatment for some patients. We hypothesized that concordance rates between biopsy and RP are different per MRI tumor volume. We conducted an explorative retrospective study to identify the risk factors for downgrading, using RP specimens as the reference standard, in a large regional prostate collaboration. Among 616 patients, pathological concordance was seen in 58% and downgrading in 15%. The risk of downgrading was 18% for tumors of 0–10 mm, 14% for 10–20 mm, and 14% for >20 mm. In a multivariable analysis among patients with targeted biopsy GG ≥2, with covariates including clinical tumor stage, prostate-specific antigen (PSA), maximal MRI index lesion diameter, number of positive target biopsies, and GG at targeted biopsy, the statistically significant predictors for downgrading were PSA, maximum MRI index lesion diameter, and target biopsy GG. A lower risk of downgrading was seen in larger tumors (odds ratio per millimeter 0.95, 95% confidence interval 0.91–1.00, p = 0.033). This study suggests that an overestimation of GG on biopsy is most common in smaller MRI lesions. This information is important in clinical decision-making, mainly in deciding on active surveillance versus active therapy or the indication for additional imaging for cancer staging. Patient summary: In this report, we examined risk factors that could explain why some patients have higher pathological grading at prostate biopsy than on the whole prostate specimen after surgical removal. We found that patients with prostate biopsies that are targeted at small lesions on magnetic resonance imaging and patients who had high biopsy grading had a higher risk of having lower grading of their surgical specimens.http://www.sciencedirect.com/science/article/pii/S2666168325000850DowngradingGleason gradeProstate cancerRadical prostatectomyTargeted biopsy |
| spellingShingle | Lisa J. Kroon Ivo I. de Vos Charlotte F. Kweldam Monique J. Roobol Geert J.L.H. van Leenders Roderick C.N. van den Bergh Targeted Prostate Biopsies Overestimate International Society of Urological Pathology Grade Group, Particularly in Smaller Tumors European Urology Open Science Downgrading Gleason grade Prostate cancer Radical prostatectomy Targeted biopsy |
| title | Targeted Prostate Biopsies Overestimate International Society of Urological Pathology Grade Group, Particularly in Smaller Tumors |
| title_full | Targeted Prostate Biopsies Overestimate International Society of Urological Pathology Grade Group, Particularly in Smaller Tumors |
| title_fullStr | Targeted Prostate Biopsies Overestimate International Society of Urological Pathology Grade Group, Particularly in Smaller Tumors |
| title_full_unstemmed | Targeted Prostate Biopsies Overestimate International Society of Urological Pathology Grade Group, Particularly in Smaller Tumors |
| title_short | Targeted Prostate Biopsies Overestimate International Society of Urological Pathology Grade Group, Particularly in Smaller Tumors |
| title_sort | targeted prostate biopsies overestimate international society of urological pathology grade group particularly in smaller tumors |
| topic | Downgrading Gleason grade Prostate cancer Radical prostatectomy Targeted biopsy |
| url | http://www.sciencedirect.com/science/article/pii/S2666168325000850 |
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