A prospective, randomized, double-blind entropy-guided approach to evaluate the efficacy of different doses of dexmedetomidine with propofol versus fentanyl with propofol for ProSeal laryngeal mask airway insertion
Background: Airway management with Proseal Laryngeal Mask Airway (PLMA) is increasingly being used. PLMA insertion requires adequate jaw relaxation and depth of anesthesia while maintaining hemodynamic stability. Opioids including fentanyl and alpha-2 agonists like dexmedetomidine are increasingly b...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Krishna Vishwa Vidyapeeth (Deemed to be University), Karad
2025-01-01
|
| Series: | Journal of Krishna Institute of Medical Sciences University |
| Subjects: | |
| Online Access: | https://www.jkimsu.com/jkimsu-vol14no1/JKIMSU,%20Vol.%2014,%20No.%201,%20January-March%202025%20Page%20116-127.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849224366093500416 |
|---|---|
| author | Mahantesh Mudakanagoudar Bhavana Koppad Manjunath Shivapujimath Meghana Hanagandi |
| author_facet | Mahantesh Mudakanagoudar Bhavana Koppad Manjunath Shivapujimath Meghana Hanagandi |
| author_sort | Mahantesh Mudakanagoudar |
| collection | DOAJ |
| description | Background: Airway management with Proseal Laryngeal Mask Airway (PLMA) is increasingly being used. PLMA insertion requires adequate jaw relaxation and depth of anesthesia while maintaining hemodynamic stability. Opioids including fentanyl and alpha-2 agonists like dexmedetomidine are increasingly being used with propofol for the same. Aims and Objectives: To assess efficacy of different dexmedetomidine doses in providing optimal conditions for insertion of PLMA, compare with that of fentanyl, and correlate with Entropy. Material and Methods: Prospective double-blind, randomized study was conducted on 120 individuals between 18 - 65 years of ASA I /II and had been randomized into 4 groups: Group 1 - Dexmedetomidine 0.5 μg/kg, Group 2 - Dexmedetomidine 0.75 μg/kg, Group 3 -
Dexmedetomidine 1μg/kg and Group 4 - Fentanyl 2μg/kg. Standard anesthesia monitors with entropy sensors were attached. Study drug was administered over 10 minutes, followed by a propofol bolus; once the State Entropy was less than 50, PLMA was inserted after assessing jaw relaxation. Results: Both groups were similar in demographic data and insertion conditions. Systolic blood pressure, mean arterial pressure, and diastolic blood pressure reductions were larger in group fentanyl. Apnea time was more infentanyl group than the dexmedetomidine group but was not statistically significant. Conclusion: Different doses of dexmedetomidine in conjunction with propofol provide identical PLMA insertion settings as fentanyl propofol combination, better maintenance advantage of hemodynamics, and less apnea incidence with adequate depth of anesthesia. |
| format | Article |
| id | doaj-art-649d41c2d6cf4fc9ad81a8950f795d8b |
| institution | Kabale University |
| issn | 2231-4261 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Krishna Vishwa Vidyapeeth (Deemed to be University), Karad |
| record_format | Article |
| series | Journal of Krishna Institute of Medical Sciences University |
| spelling | doaj-art-649d41c2d6cf4fc9ad81a8950f795d8b2025-08-25T11:13:51ZengKrishna Vishwa Vidyapeeth (Deemed to be University), KaradJournal of Krishna Institute of Medical Sciences University2231-42612025-01-01141116127A prospective, randomized, double-blind entropy-guided approach to evaluate the efficacy of different doses of dexmedetomidine with propofol versus fentanyl with propofol for ProSeal laryngeal mask airway insertionMahantesh Mudakanagoudar0Bhavana Koppad1Manjunath Shivapujimath2Meghana Hanagandi3Department of Anaesthesiology, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (KAHER) Belagavi-590010 (Karnataka) IndiaDepartment of Paediatrics, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (KAHER) Belagavi-590010 (Karnataka) IndiaDepartment of Anaesthesiology, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (KAHER) Belagavi-590010 (Karnataka) IndiaDepartment of Anaesthesiology, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (KAHER) Belagavi-590010 (Karnataka) IndiaBackground: Airway management with Proseal Laryngeal Mask Airway (PLMA) is increasingly being used. PLMA insertion requires adequate jaw relaxation and depth of anesthesia while maintaining hemodynamic stability. Opioids including fentanyl and alpha-2 agonists like dexmedetomidine are increasingly being used with propofol for the same. Aims and Objectives: To assess efficacy of different dexmedetomidine doses in providing optimal conditions for insertion of PLMA, compare with that of fentanyl, and correlate with Entropy. Material and Methods: Prospective double-blind, randomized study was conducted on 120 individuals between 18 - 65 years of ASA I /II and had been randomized into 4 groups: Group 1 - Dexmedetomidine 0.5 μg/kg, Group 2 - Dexmedetomidine 0.75 μg/kg, Group 3 - Dexmedetomidine 1μg/kg and Group 4 - Fentanyl 2μg/kg. Standard anesthesia monitors with entropy sensors were attached. Study drug was administered over 10 minutes, followed by a propofol bolus; once the State Entropy was less than 50, PLMA was inserted after assessing jaw relaxation. Results: Both groups were similar in demographic data and insertion conditions. Systolic blood pressure, mean arterial pressure, and diastolic blood pressure reductions were larger in group fentanyl. Apnea time was more infentanyl group than the dexmedetomidine group but was not statistically significant. Conclusion: Different doses of dexmedetomidine in conjunction with propofol provide identical PLMA insertion settings as fentanyl propofol combination, better maintenance advantage of hemodynamics, and less apnea incidence with adequate depth of anesthesia.https://www.jkimsu.com/jkimsu-vol14no1/JKIMSU,%20Vol.%2014,%20No.%201,%20January-March%202025%20Page%20116-127.pdfproseal laryngeal mask airwaydexmedetomidinefentanylentropy |
| spellingShingle | Mahantesh Mudakanagoudar Bhavana Koppad Manjunath Shivapujimath Meghana Hanagandi A prospective, randomized, double-blind entropy-guided approach to evaluate the efficacy of different doses of dexmedetomidine with propofol versus fentanyl with propofol for ProSeal laryngeal mask airway insertion Journal of Krishna Institute of Medical Sciences University proseal laryngeal mask airway dexmedetomidine fentanyl entropy |
| title | A prospective, randomized, double-blind entropy-guided approach to evaluate the efficacy of different doses of dexmedetomidine with propofol versus fentanyl with propofol for ProSeal laryngeal mask airway insertion |
| title_full | A prospective, randomized, double-blind entropy-guided approach to evaluate the efficacy of different doses of dexmedetomidine with propofol versus fentanyl with propofol for ProSeal laryngeal mask airway insertion |
| title_fullStr | A prospective, randomized, double-blind entropy-guided approach to evaluate the efficacy of different doses of dexmedetomidine with propofol versus fentanyl with propofol for ProSeal laryngeal mask airway insertion |
| title_full_unstemmed | A prospective, randomized, double-blind entropy-guided approach to evaluate the efficacy of different doses of dexmedetomidine with propofol versus fentanyl with propofol for ProSeal laryngeal mask airway insertion |
| title_short | A prospective, randomized, double-blind entropy-guided approach to evaluate the efficacy of different doses of dexmedetomidine with propofol versus fentanyl with propofol for ProSeal laryngeal mask airway insertion |
| title_sort | prospective randomized double blind entropy guided approach to evaluate the efficacy of different doses of dexmedetomidine with propofol versus fentanyl with propofol for proseal laryngeal mask airway insertion |
| topic | proseal laryngeal mask airway dexmedetomidine fentanyl entropy |
| url | https://www.jkimsu.com/jkimsu-vol14no1/JKIMSU,%20Vol.%2014,%20No.%201,%20January-March%202025%20Page%20116-127.pdf |
| work_keys_str_mv | AT mahanteshmudakanagoudar aprospectiverandomizeddoubleblindentropyguidedapproachtoevaluatetheefficacyofdifferentdosesofdexmedetomidinewithpropofolversusfentanylwithpropofolforproseallaryngealmaskairwayinsertion AT bhavanakoppad aprospectiverandomizeddoubleblindentropyguidedapproachtoevaluatetheefficacyofdifferentdosesofdexmedetomidinewithpropofolversusfentanylwithpropofolforproseallaryngealmaskairwayinsertion AT manjunathshivapujimath aprospectiverandomizeddoubleblindentropyguidedapproachtoevaluatetheefficacyofdifferentdosesofdexmedetomidinewithpropofolversusfentanylwithpropofolforproseallaryngealmaskairwayinsertion AT meghanahanagandi aprospectiverandomizeddoubleblindentropyguidedapproachtoevaluatetheefficacyofdifferentdosesofdexmedetomidinewithpropofolversusfentanylwithpropofolforproseallaryngealmaskairwayinsertion AT mahanteshmudakanagoudar prospectiverandomizeddoubleblindentropyguidedapproachtoevaluatetheefficacyofdifferentdosesofdexmedetomidinewithpropofolversusfentanylwithpropofolforproseallaryngealmaskairwayinsertion AT bhavanakoppad prospectiverandomizeddoubleblindentropyguidedapproachtoevaluatetheefficacyofdifferentdosesofdexmedetomidinewithpropofolversusfentanylwithpropofolforproseallaryngealmaskairwayinsertion AT manjunathshivapujimath prospectiverandomizeddoubleblindentropyguidedapproachtoevaluatetheefficacyofdifferentdosesofdexmedetomidinewithpropofolversusfentanylwithpropofolforproseallaryngealmaskairwayinsertion AT meghanahanagandi prospectiverandomizeddoubleblindentropyguidedapproachtoevaluatetheefficacyofdifferentdosesofdexmedetomidinewithpropofolversusfentanylwithpropofolforproseallaryngealmaskairwayinsertion |