Gait and balance dysfunction are associated with cognitive performance only in men with Parkinson’s disease
Introduction: Parkinson’s disease (PD) can cause locomotor dysfunction and cognitive impairment and these symptoms are often associated. This study assesses relationships between comprehensive cognitive performance and locomotor function domains: gait, balance, and mobility, in men and women with PD...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Clinical Parkinsonism & Related Disorders |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590112525000672 |
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| author | Amy W. Amara Kimberly H. Wood Aya M. Miften Lina Kleinschmidt Corey S. White Allen Joop Raima A. Memon Jennifer Pilkington Jutaluk Kongsuk Corina Catiul Adeel A. Memon Marcas M. Bamman Christopher P. Hurt |
| author_facet | Amy W. Amara Kimberly H. Wood Aya M. Miften Lina Kleinschmidt Corey S. White Allen Joop Raima A. Memon Jennifer Pilkington Jutaluk Kongsuk Corina Catiul Adeel A. Memon Marcas M. Bamman Christopher P. Hurt |
| author_sort | Amy W. Amara |
| collection | DOAJ |
| description | Introduction: Parkinson’s disease (PD) can cause locomotor dysfunction and cognitive impairment and these symptoms are often associated. This study assesses relationships between comprehensive cognitive performance and locomotor function domains: gait, balance, and mobility, in men and women with PD. Methods: Sixty PD participants, Hoehn and Yahr 1–3, age ≥ 45, and Montreal Cognitive Assessment score ≥ 18, underwent locomotor function assessments and a comprehensive neurocognitive battery. Primary outcomes included Timed Up and Go (TUG), maximum walking speed (MWS), Mini Balance Evaluation Systems Test (Mini-BESTest), and cognitive composite score (CCS). Spearman correlations determined associations between cognition and locomotor function for the total sample and separately for men and women. Results: CCS correlated with all primary locomotor outcomes for the overall group and men only. Specifically, positive relationships were observed between the CCS and Mini-BEST Test (balance) for the overall group (p = 0.009) and men (p = 0.001), as well as MWS (gait) for the overall group (p = 0.006) and men (p < 0.001). CCS and TUG (mobility) were negatively correlated for the overall group (p = 0.005) and men (p < 0.001). There were no significant correlations between CCS and locomotor outcomes in women. Exploratory analyses suggest that performance in executive function, visuospatial skills, and processing speed drive these relationships. Conclusion: In PD, balance, gait, and mobility correlated with global cognition. Correlations between motor function and cognitive performance were evident only in men. This study enhances understanding of the complex interplay between cognition and motor function in PD, especially among men. |
| format | Article |
| id | doaj-art-649c2c7e146a46d0a402adc7f21dfbbd |
| institution | OA Journals |
| issn | 2590-1125 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Parkinsonism & Related Disorders |
| spelling | doaj-art-649c2c7e146a46d0a402adc7f21dfbbd2025-08-20T02:36:16ZengElsevierClinical Parkinsonism & Related Disorders2590-11252025-01-011310036310.1016/j.prdoa.2025.100363Gait and balance dysfunction are associated with cognitive performance only in men with Parkinson’s diseaseAmy W. Amara0Kimberly H. Wood1Aya M. Miften2Lina Kleinschmidt3Corey S. White4Allen Joop5Raima A. Memon6Jennifer Pilkington7Jutaluk Kongsuk8Corina Catiul9Adeel A. Memon10Marcas M. Bamman11Christopher P. Hurt12Department of Neurology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA; Corresponding author.Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; UAB Center for Exercise Medicine, Birmingham, AL 35205, USA; Department of Psychology, Samford University, Birmingham, AL 35229, USA; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Neurology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Neurology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Psychology, University of Louisiana at Monroe, Monroe, LA 71209, USADepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USADepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35233, USA; Department of Physical Therapy, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, ThailandDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Neurology, West Virginia University Rockefeller Neuroscience Institute, Morgantown, WV 25605, USAFlorida Institute for Human & Machine Cognition, Pensacola, FL 32502, USAUAB Center for Exercise Medicine, Birmingham, AL 35205, USA; Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35233, USAIntroduction: Parkinson’s disease (PD) can cause locomotor dysfunction and cognitive impairment and these symptoms are often associated. This study assesses relationships between comprehensive cognitive performance and locomotor function domains: gait, balance, and mobility, in men and women with PD. Methods: Sixty PD participants, Hoehn and Yahr 1–3, age ≥ 45, and Montreal Cognitive Assessment score ≥ 18, underwent locomotor function assessments and a comprehensive neurocognitive battery. Primary outcomes included Timed Up and Go (TUG), maximum walking speed (MWS), Mini Balance Evaluation Systems Test (Mini-BESTest), and cognitive composite score (CCS). Spearman correlations determined associations between cognition and locomotor function for the total sample and separately for men and women. Results: CCS correlated with all primary locomotor outcomes for the overall group and men only. Specifically, positive relationships were observed between the CCS and Mini-BEST Test (balance) for the overall group (p = 0.009) and men (p = 0.001), as well as MWS (gait) for the overall group (p = 0.006) and men (p < 0.001). CCS and TUG (mobility) were negatively correlated for the overall group (p = 0.005) and men (p < 0.001). There were no significant correlations between CCS and locomotor outcomes in women. Exploratory analyses suggest that performance in executive function, visuospatial skills, and processing speed drive these relationships. Conclusion: In PD, balance, gait, and mobility correlated with global cognition. Correlations between motor function and cognitive performance were evident only in men. This study enhances understanding of the complex interplay between cognition and motor function in PD, especially among men.http://www.sciencedirect.com/science/article/pii/S2590112525000672 |
| spellingShingle | Amy W. Amara Kimberly H. Wood Aya M. Miften Lina Kleinschmidt Corey S. White Allen Joop Raima A. Memon Jennifer Pilkington Jutaluk Kongsuk Corina Catiul Adeel A. Memon Marcas M. Bamman Christopher P. Hurt Gait and balance dysfunction are associated with cognitive performance only in men with Parkinson’s disease Clinical Parkinsonism & Related Disorders |
| title | Gait and balance dysfunction are associated with cognitive performance only in men with Parkinson’s disease |
| title_full | Gait and balance dysfunction are associated with cognitive performance only in men with Parkinson’s disease |
| title_fullStr | Gait and balance dysfunction are associated with cognitive performance only in men with Parkinson’s disease |
| title_full_unstemmed | Gait and balance dysfunction are associated with cognitive performance only in men with Parkinson’s disease |
| title_short | Gait and balance dysfunction are associated with cognitive performance only in men with Parkinson’s disease |
| title_sort | gait and balance dysfunction are associated with cognitive performance only in men with parkinson s disease |
| url | http://www.sciencedirect.com/science/article/pii/S2590112525000672 |
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