Effect of meloxicam on serum vitamin and cytokine levels during endotoxemia
<b>Aim:</b> The aim of this study is to evaluate the effects of meloxicam on serum vitamin and cytokine levels during lipopolysaccharide-induced endotoxemia. Serum biochemical concentrations were also evaluated.<p> <b>Materials and Methods:</b> Fifty male adult Sprague...
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=464 |
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| Summary: | <b>Aim:</b> The aim of this study is to evaluate the effects of
meloxicam on serum vitamin and cytokine levels during
lipopolysaccharide-induced endotoxemia. Serum biochemical
concentrations were also evaluated.<p>
<b>Materials and Methods:</b> Fifty male adult Sprague Dawley
rats were used in this research. Five rats were reserved to
obtain 0 time data then the rest were divided into 3 equal
groups. First group received lipopolysaccharide (4 mg, intraperitoneal),
second group received meloxicam (50 mg/
kg, intraperitoneal) and third group received lipopolysaccharide
(4 mg, intraperitoneal) plus meloxicam (50 mg/kg,
intraperitoneal). Blood samples were collected at 2, 4 and
8 hours after administrations. Serum retinol, β-carotene,
vitamin C, interleukin-1α, interleukin-1β, interleukin-2 and
routine biochemical values were measured.<p>
<b>Results:</b> After lipopolysaccharide administration, decreased
β-carotene level (p<0.05) was inhibited by meloxicam
while increased interleukin-1α level (p<0.05) could
not. Lipopolysaccharide caused increase in damage indicator
levels of heart, liver, kidney besides cholesterol and
triglyceride (p<0.05) while meloxicam administration was
inhibited increase in creatine kinase-MB and cholesterol
levels but caused more increase in urea and triglyceride
levels.<p>
<b>Conclusion:</b> Meloxicam may be useful in inhibiting vitamin
loses and heart damage. In addition, non-steroidal anti-inflammatory
drug and vitamin supplementation may be useful
during acute phase of endotoxemia. |
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| ISSN: | 1309-6958 2146-1953 |