Association between transcriptomic metrics of exogenous antigen presentation and adaptive immunity with locoregional recurrence in localized estrogen receptor negative breast cancer: retrospective review of multi-institutional datasets

Association between transcriptomic metrics of exogenous antigen presentation and adaptive immunity with locoregional recurrence in localized estrogen receptor negative breast cancer: retrospective review of multi-institutional datasets

Abstract Background Transcriptomic features of breast cancer locoregional recurrence (LRR) remain poorly understood. We therefore sought to investigate transcriptomic features associated with LRR in newly diagnosed invasive breast tumors from our institutional dataset. Methods Transcriptomic profili...

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Main Authors: Timothy J. Robinson, Casey L. Liveringhouse, Christopher Wilson, Sam Friedman, Justyn Nakashima, Matthew N. Mills, Jacob D. Purcell, Nicholas B. Figura, Du Dongliang, Ram Thapa, Eric Welsh, Kamran A. Ahmed, G. Daniel Grass, Brooke L. Fridley, Roberto Diaz
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Estrogen receptor negative
Immune response
Locoregional control
Online Access:https://doi.org/10.1186/s13058-025-01987-x
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