Acetyl-L-carnitine ameliorates atherosclerosis in LDLR−/− mice by modulating cholesterol metabolism through SREBP2-dependent cholesterol biosynthesis

Acetyl-L-carnitine ameliorates atherosclerosis in LDLR−/− mice by modulating cholesterol metabolism through SREBP2-dependent cholesterol biosynthesis

BackgroundAtherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality globally. Hypercholesterolemia accelerates atherosclerotic development and is an independent modifiable risk factor for ASCVD. Reducing cholesterol levels is effective in preventing ASCVD. Acetyl-L-carnitine (...

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Bibliographic Details
Main Authors: Jingci Xing, Zhiyong Du, Fan Li, Yu Wang, Zihan Zhang, Xiaoqian Gao, Lijie Han, Xuechun Sun, Haili Sun, Yunhui Du, Chaowei Hu, Huahui Yu, Yanwen Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Nutrition
Subjects:
atheroscelrosis
cholesterol metabolism
acetyl-L-carnitine (ALC)
SREBP2
HMGCR
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2024.1509577/full
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