Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia
Objective. The aim of this study was to investigate the anti-inflammatory effects of the crude extract (CE), derived fraction, and isolated compounds from Calea pinnatifida leaves in a mouse model of pulmonary neutrophilia. Methods. The CE and derived fractions, hexane, ethyl acetate, and methanol,...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/4620251 |
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| author | Bruno Matheus de Campos Facchin Julia Salvan da Rosa Ana Beatriz Gobbo Luz Yeo Jim Kinoshita Moon Tamires Cardoso de Lima Rosana Casoti Maique Weber Biavatti Eduardo Monguilhott Dalmarco Tânia Silvia Fröde |
| author_facet | Bruno Matheus de Campos Facchin Julia Salvan da Rosa Ana Beatriz Gobbo Luz Yeo Jim Kinoshita Moon Tamires Cardoso de Lima Rosana Casoti Maique Weber Biavatti Eduardo Monguilhott Dalmarco Tânia Silvia Fröde |
| author_sort | Bruno Matheus de Campos Facchin |
| collection | DOAJ |
| description | Objective. The aim of this study was to investigate the anti-inflammatory effects of the crude extract (CE), derived fraction, and isolated compounds from Calea pinnatifida leaves in a mouse model of pulmonary neutrophilia. Methods. The CE and derived fractions, hexane, ethyl acetate, and methanol, were obtained from C. pinnatifida leaves. The compounds 3,5- and 4,5-di-O-E-caffeoylquinic acids were isolated from the EtOAc fraction using chromatography and were identified using infrared spectroscopic data and nuclear magnetic resonance (1H and 13C NMR). Leukocytes count, protein concentration of the exudate, myeloperoxidase (MPO) and adenosine deaminase (ADA), and nitrate/nitrite (NOx), tumor necrosis factor-alpha (TNF-α), interleukin-1-beta (IL-1β), and interleukin-17A (IL-17A) levels were determined in the pleural fluid leakage after 4 h of pleurisy induction. We also analyzed the effects of isolated compounds on the phosphorylation of both p65 and p38 in the lung tissue. Results. The CE, its fractions, and isolated compounds inhibited leukocyte activation, protein concentration of the exudate, and MPO, ADA, NOx, TNF-α, IL-1β, and IL-17A levels. 3,5- and 4,5-di-O-E-caffeoylquinic acids also inhibited phosphorylation of both p65 and p38 (P<0.05). Conclusion. This study demonstrated that C. pinnatifida presents important anti-inflammatory properties by inhibiting activated leukocytes and protein concentration of the exudate. These effects were related to the inhibition of proinflammatory mediators. The dicaffeoylquinic acids may be partially responsible for these anti-inflammatory properties through the inhibition of nuclear transcription factor kappa B and mitogen-activated protein kinase pathways. |
| format | Article |
| id | doaj-art-648b707fd0224efe90cb90fce5cc764a |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-648b707fd0224efe90cb90fce5cc764a2025-08-20T02:23:51ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/46202514620251Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary NeutrophiliaBruno Matheus de Campos Facchin0Julia Salvan da Rosa1Ana Beatriz Gobbo Luz2Yeo Jim Kinoshita Moon3Tamires Cardoso de Lima4Rosana Casoti5Maique Weber Biavatti6Eduardo Monguilhott Dalmarco7Tânia Silvia Fröde8Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, 88040-970 SC-, BrazilDepartment of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, 88040-970 SC-, BrazilDepartment of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, 88040-970 SC-, BrazilDepartment of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, 88040-970 SC-, BrazilDepartment of Pharmaceutical Sciences, Center of Health Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, 88040-970 SC-, BrazilDepartment of Pharmaceutical Sciences, University of São Paulo, Ribeirão Preto, SP-, BrazilDepartment of Pharmaceutical Sciences, Center of Health Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, 88040-970 SC-, BrazilDepartment of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, 88040-970 SC-, BrazilDepartment of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, 88040-970 SC-, BrazilObjective. The aim of this study was to investigate the anti-inflammatory effects of the crude extract (CE), derived fraction, and isolated compounds from Calea pinnatifida leaves in a mouse model of pulmonary neutrophilia. Methods. The CE and derived fractions, hexane, ethyl acetate, and methanol, were obtained from C. pinnatifida leaves. The compounds 3,5- and 4,5-di-O-E-caffeoylquinic acids were isolated from the EtOAc fraction using chromatography and were identified using infrared spectroscopic data and nuclear magnetic resonance (1H and 13C NMR). Leukocytes count, protein concentration of the exudate, myeloperoxidase (MPO) and adenosine deaminase (ADA), and nitrate/nitrite (NOx), tumor necrosis factor-alpha (TNF-α), interleukin-1-beta (IL-1β), and interleukin-17A (IL-17A) levels were determined in the pleural fluid leakage after 4 h of pleurisy induction. We also analyzed the effects of isolated compounds on the phosphorylation of both p65 and p38 in the lung tissue. Results. The CE, its fractions, and isolated compounds inhibited leukocyte activation, protein concentration of the exudate, and MPO, ADA, NOx, TNF-α, IL-1β, and IL-17A levels. 3,5- and 4,5-di-O-E-caffeoylquinic acids also inhibited phosphorylation of both p65 and p38 (P<0.05). Conclusion. This study demonstrated that C. pinnatifida presents important anti-inflammatory properties by inhibiting activated leukocytes and protein concentration of the exudate. These effects were related to the inhibition of proinflammatory mediators. The dicaffeoylquinic acids may be partially responsible for these anti-inflammatory properties through the inhibition of nuclear transcription factor kappa B and mitogen-activated protein kinase pathways.http://dx.doi.org/10.1155/2020/4620251 |
| spellingShingle | Bruno Matheus de Campos Facchin Julia Salvan da Rosa Ana Beatriz Gobbo Luz Yeo Jim Kinoshita Moon Tamires Cardoso de Lima Rosana Casoti Maique Weber Biavatti Eduardo Monguilhott Dalmarco Tânia Silvia Fröde Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia Mediators of Inflammation |
| title | Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia |
| title_full | Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia |
| title_fullStr | Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia |
| title_full_unstemmed | Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia |
| title_short | Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia |
| title_sort | systemic administration of calea pinnatifida inhibits inflammation induced by carrageenan in a murine model of pulmonary neutrophilia |
| url | http://dx.doi.org/10.1155/2020/4620251 |
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