Revolutionizing cancer treatment with Halomonas Aquamarina L-Glutaminase: insights from in vitro and computational studies

Revolutionizing cancer treatment with Halomonas Aquamarina L-Glutaminase: insights from in vitro and computational studies

Abstract Bacterial L-glutaminase (L-GLS) has emerged as a potential therapeutic target in cancer treatment by disrupting glutamine-dependent metabolic pathways in tumor cells. This study focused on isolating and characterizing L-GLS-producing marine bacteria from Mediterranean seawater for prelimina...

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Bibliographic Details
Main Authors: Sara Abdelsayed, Alaa Elmetwalli, Jihan Hassan, Mohamed O. Abdel Monem, Ali H. El-Far, Fuad Ameen, Mervat G. Hassan
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Enzyme activity
Halomonas Aquamarina
L-glutaminase
Liver cancer
Tannic acid
Online Access:https://doi.org/10.1038/s41598-025-14230-6
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