SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans.
SARS-CoV-2 infection in minks has become a serious problem, as the virus may mutate and reinfect humans; some countries have decided to cull minks. Here, the virus sequencing data in minks were analysed and compared to those of human-virus. Although the mink-virus maintained the characteristics of h...
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| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247626&type=printable |
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| author | Tomokazu Konishi |
| author_facet | Tomokazu Konishi |
| author_sort | Tomokazu Konishi |
| collection | DOAJ |
| description | SARS-CoV-2 infection in minks has become a serious problem, as the virus may mutate and reinfect humans; some countries have decided to cull minks. Here, the virus sequencing data in minks were analysed and compared to those of human-virus. Although the mink-virus maintained the characteristics of human-virus, some variants rapidly mutated, adapting to minks. Some mink-derived variants infected humans, which accounted for 40% of the total SARS-CoV-2 cases in the Netherlands. These variants appear to be less lethal and infective compared to those in humans. Variants that have mutated further among minks were not found in humans. Such mink-viruses might be suitable for vaccination for humans, such as in the case of the smallpox virus, which is less infective and toxic to humans. |
| format | Article |
| id | doaj-art-648794ce154a4e07b59c34a13d74235d |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-648794ce154a4e07b59c34a13d74235d2025-08-20T02:17:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01165e024762610.1371/journal.pone.0247626SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans.Tomokazu KonishiSARS-CoV-2 infection in minks has become a serious problem, as the virus may mutate and reinfect humans; some countries have decided to cull minks. Here, the virus sequencing data in minks were analysed and compared to those of human-virus. Although the mink-virus maintained the characteristics of human-virus, some variants rapidly mutated, adapting to minks. Some mink-derived variants infected humans, which accounted for 40% of the total SARS-CoV-2 cases in the Netherlands. These variants appear to be less lethal and infective compared to those in humans. Variants that have mutated further among minks were not found in humans. Such mink-viruses might be suitable for vaccination for humans, such as in the case of the smallpox virus, which is less infective and toxic to humans.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247626&type=printable |
| spellingShingle | Tomokazu Konishi SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans. PLoS ONE |
| title | SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans. |
| title_full | SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans. |
| title_fullStr | SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans. |
| title_full_unstemmed | SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans. |
| title_short | SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans. |
| title_sort | sars cov 2 mutations among minks show reduced lethality and infectivity to humans |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247626&type=printable |
| work_keys_str_mv | AT tomokazukonishi sarscov2mutationsamongminksshowreducedlethalityandinfectivitytohumans |