Post-translational modifications of ezrin: a crucial regulator for diseases
Abstract Ezrin is a crucial structural protein that connects the plasma membrane to the actin cytoskeleton to maintain cell shape, adhesion, and motility. Post-translational modifications (PTMs) play a key role in the regulation of various biological functions and have been implicated in a range of...
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| Format: | Article |
| Language: | English |
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Springer
2025-08-01
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| Series: | Amino Acids |
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| Online Access: | https://doi.org/10.1007/s00726-025-03472-3 |
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| author | Yi-Chen Li Hong-Kai Yuan Lei-Miao Yin |
| author_facet | Yi-Chen Li Hong-Kai Yuan Lei-Miao Yin |
| author_sort | Yi-Chen Li |
| collection | DOAJ |
| description | Abstract Ezrin is a crucial structural protein that connects the plasma membrane to the actin cytoskeleton to maintain cell shape, adhesion, and motility. Post-translational modifications (PTMs) play a key role in the regulation of various biological functions and have been implicated in a range of pathological conditions. With the help of PTMs, ezrin not only plays a structural role in connecting the cell membrane to F-actin, but also participates in transmitting cellular signals including those related to inflammatory responses. In this study, we reviewed the key sites and domains involved in the different PTMs of ezrin, including acetylation, lactylation and phosphorylation. We analyzed the regulation of biological processes mediated by different PTMs of ezrin, such as cell migration, inflammation regulation and cell stiffness. In addition, we examined the mutual regulatory effects of different modifications of ezrin, including regulation of ezrin phosphorylation by kinases and phosphatases, and so on. Increasing evidence suggests that PTMs of ezrin are involved in cancer, respiratory diseases and urological diseases. These studies provide novel insights into the design of new disease treatment strategies targeting ezrin. |
| format | Article |
| id | doaj-art-64834efe53a4437faebd242bbcd58a91 |
| institution | Kabale University |
| issn | 1438-2199 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Amino Acids |
| spelling | doaj-art-64834efe53a4437faebd242bbcd58a912025-08-20T03:46:23ZengSpringerAmino Acids1438-21992025-08-0157111010.1007/s00726-025-03472-3Post-translational modifications of ezrin: a crucial regulator for diseasesYi-Chen Li0Hong-Kai Yuan1Lei-Miao Yin2Yueyang Hospital, Shanghai University of Traditional Chinese MedicineYueyang Hospital, Shanghai University of Traditional Chinese MedicineYueyang Hospital, Shanghai University of Traditional Chinese MedicineAbstract Ezrin is a crucial structural protein that connects the plasma membrane to the actin cytoskeleton to maintain cell shape, adhesion, and motility. Post-translational modifications (PTMs) play a key role in the regulation of various biological functions and have been implicated in a range of pathological conditions. With the help of PTMs, ezrin not only plays a structural role in connecting the cell membrane to F-actin, but also participates in transmitting cellular signals including those related to inflammatory responses. In this study, we reviewed the key sites and domains involved in the different PTMs of ezrin, including acetylation, lactylation and phosphorylation. We analyzed the regulation of biological processes mediated by different PTMs of ezrin, such as cell migration, inflammation regulation and cell stiffness. In addition, we examined the mutual regulatory effects of different modifications of ezrin, including regulation of ezrin phosphorylation by kinases and phosphatases, and so on. Increasing evidence suggests that PTMs of ezrin are involved in cancer, respiratory diseases and urological diseases. These studies provide novel insights into the design of new disease treatment strategies targeting ezrin.https://doi.org/10.1007/s00726-025-03472-3EzrinPost-translational modificationsAcetylationUbiquitinationLactylationPhosphorylation |
| spellingShingle | Yi-Chen Li Hong-Kai Yuan Lei-Miao Yin Post-translational modifications of ezrin: a crucial regulator for diseases Amino Acids Ezrin Post-translational modifications Acetylation Ubiquitination Lactylation Phosphorylation |
| title | Post-translational modifications of ezrin: a crucial regulator for diseases |
| title_full | Post-translational modifications of ezrin: a crucial regulator for diseases |
| title_fullStr | Post-translational modifications of ezrin: a crucial regulator for diseases |
| title_full_unstemmed | Post-translational modifications of ezrin: a crucial regulator for diseases |
| title_short | Post-translational modifications of ezrin: a crucial regulator for diseases |
| title_sort | post translational modifications of ezrin a crucial regulator for diseases |
| topic | Ezrin Post-translational modifications Acetylation Ubiquitination Lactylation Phosphorylation |
| url | https://doi.org/10.1007/s00726-025-03472-3 |
| work_keys_str_mv | AT yichenli posttranslationalmodificationsofezrinacrucialregulatorfordiseases AT hongkaiyuan posttranslationalmodificationsofezrinacrucialregulatorfordiseases AT leimiaoyin posttranslationalmodificationsofezrinacrucialregulatorfordiseases |