Comparison of peripapillary and macular Optical Coherence Tomography parameters between children and young adults
Purpose: To compare the retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer thickness, central subfield thickness (CSFT), and parafoveal and perifoveal thickness in children of different age groups with young adult controls by using spectral-domain optical coherence tomography. Met...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_889_24 |
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| author | Gazella B Warjri Harsha L Rao Virender Sachdeva Sirisha Senthil |
| author_facet | Gazella B Warjri Harsha L Rao Virender Sachdeva Sirisha Senthil |
| author_sort | Gazella B Warjri |
| collection | DOAJ |
| description | Purpose:
To compare the retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer thickness, central subfield thickness (CSFT), and parafoveal and perifoveal thickness in children of different age groups with young adult controls by using spectral-domain optical coherence tomography.
Methods:
This cross-sectional study included children aged 6–17 years and adult controls (18–22 years) – group 1: 6–9 years (57 eyes), group 2: 10–13 years (116 eyes), group 3: 14–17 years (66 eyes), and group 4 (controls): 18–22 years (61 eyes). A mixed-effects model was used to compare the OCT parameters among the groups, along with multivariable analysis.
Results:
Analysis of 300 eyes of 152 patients was done. Group 2 (99.7 ± 1.1 µm, P = 0.03) and group 3 (100.4 ± 1.5 µm, P = 0.03) had thicker RNFL on average as compared to group 4 (95.6 ± 1.6 µm) on multivariable analysis. In pairwise comparison, group 2 (129.8 ± 2.5 µm, P = 0.02) and group 3 (132.6 ± 2.4 µm, P = 0.004) had thicker inferior RNFL compared to adult controls (122.4 ± 2.5 µm); superior RNFL was thicker in group 2 (129.6 ± 2.0 µm, P = 0.01) and group 3 (131.2 ± 2.6 µm, P = 0.008) compared to group 1 (120.9 ± 2.8 µm). On multivariable analysis, adult controls had thicker CSFT (236.5 ± 2.6 µm) than group 1 (222.7 ± 3.1 µm) and group 2 (229.6 ± 2.3 µm). Similarly, on pairwise comparison, adult controls had thicker parafoveal superior quadrants (320.5 ± 2.5 µm) and inferior quadrants (317.5 ± 2.3 µm) when compared with groups 1 and 2.
Conclusion:
RNFL thickness seems to increase up to 17 years and then starts reducing, unlike CSFT, which increases with age from 6 to 22 years. A differential growth occurs in the different quadrants of RNFL and macula with age with some quadrants increasing in thickness as compared to the others. |
| format | Article |
| id | doaj-art-6482be4d31694e7ea04ab67a1969a1e8 |
| institution | OA Journals |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-6482be4d31694e7ea04ab67a1969a1e82025-08-20T02:11:15ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892025-05-0173573173610.4103/IJO.IJO_889_24Comparison of peripapillary and macular Optical Coherence Tomography parameters between children and young adultsGazella B WarjriHarsha L RaoVirender SachdevaSirisha SenthilPurpose: To compare the retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer thickness, central subfield thickness (CSFT), and parafoveal and perifoveal thickness in children of different age groups with young adult controls by using spectral-domain optical coherence tomography. Methods: This cross-sectional study included children aged 6–17 years and adult controls (18–22 years) – group 1: 6–9 years (57 eyes), group 2: 10–13 years (116 eyes), group 3: 14–17 years (66 eyes), and group 4 (controls): 18–22 years (61 eyes). A mixed-effects model was used to compare the OCT parameters among the groups, along with multivariable analysis. Results: Analysis of 300 eyes of 152 patients was done. Group 2 (99.7 ± 1.1 µm, P = 0.03) and group 3 (100.4 ± 1.5 µm, P = 0.03) had thicker RNFL on average as compared to group 4 (95.6 ± 1.6 µm) on multivariable analysis. In pairwise comparison, group 2 (129.8 ± 2.5 µm, P = 0.02) and group 3 (132.6 ± 2.4 µm, P = 0.004) had thicker inferior RNFL compared to adult controls (122.4 ± 2.5 µm); superior RNFL was thicker in group 2 (129.6 ± 2.0 µm, P = 0.01) and group 3 (131.2 ± 2.6 µm, P = 0.008) compared to group 1 (120.9 ± 2.8 µm). On multivariable analysis, adult controls had thicker CSFT (236.5 ± 2.6 µm) than group 1 (222.7 ± 3.1 µm) and group 2 (229.6 ± 2.3 µm). Similarly, on pairwise comparison, adult controls had thicker parafoveal superior quadrants (320.5 ± 2.5 µm) and inferior quadrants (317.5 ± 2.3 µm) when compared with groups 1 and 2. Conclusion: RNFL thickness seems to increase up to 17 years and then starts reducing, unlike CSFT, which increases with age from 6 to 22 years. A differential growth occurs in the different quadrants of RNFL and macula with age with some quadrants increasing in thickness as compared to the others.https://journals.lww.com/10.4103/IJO.IJO_889_24ganglion cell inner plexiform layeroct normative databaseretinal nerve fiber layerspectral-domain optical coherence tomographysd-oct |
| spellingShingle | Gazella B Warjri Harsha L Rao Virender Sachdeva Sirisha Senthil Comparison of peripapillary and macular Optical Coherence Tomography parameters between children and young adults Indian Journal of Ophthalmology ganglion cell inner plexiform layer oct normative database retinal nerve fiber layer spectral-domain optical coherence tomography sd-oct |
| title | Comparison of peripapillary and macular Optical Coherence Tomography parameters between children and young adults |
| title_full | Comparison of peripapillary and macular Optical Coherence Tomography parameters between children and young adults |
| title_fullStr | Comparison of peripapillary and macular Optical Coherence Tomography parameters between children and young adults |
| title_full_unstemmed | Comparison of peripapillary and macular Optical Coherence Tomography parameters between children and young adults |
| title_short | Comparison of peripapillary and macular Optical Coherence Tomography parameters between children and young adults |
| title_sort | comparison of peripapillary and macular optical coherence tomography parameters between children and young adults |
| topic | ganglion cell inner plexiform layer oct normative database retinal nerve fiber layer spectral-domain optical coherence tomography sd-oct |
| url | https://journals.lww.com/10.4103/IJO.IJO_889_24 |
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