Tri-culture model of intestinal epithelial cell, macrophage, and bacteria for the triggering of inflammatory bowel disease on a microfluidic device

Tri-culture model of intestinal epithelial cell, macrophage, and bacteria for the triggering of inflammatory bowel disease on a microfluidic device

Inflammatory bowel disease (IBD) involves gastrointestinal inflammation, due to intestinal epithelial barrier destruction caused by excessive immune activation. Conventional cell culture systems do not provide a model system that can recapitulate the complex interactions between epithelial cells, im...

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Bibliographic Details
Main Authors: Shiori Tamura, Clarissa Ellice Talitha Pasang, Minami Tsuda, Shilan Ma, Hiromasa Shindo, Noriyuki Nagaoka, Tomoki Ohkubo, Yoichi Fujiyama, Miho Tamai, Yoh-ichi Tagawa
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:European Journal of Cell Biology
Subjects:
Intestine chip
Inflammatory bowel disease
Co-culture
Tri-culture
Fluidic device
Disease model
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933525000202
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