Metabolic diseases and interferon immune responses
Abstract Metabolic diseases, including obesity, diabetes, and metabolic‐associated fatty liver disease (MAFLD), are increasingly common worldwide, posing a significant public health challenge. Recent research has revealed a complex interplay between these metabolic disorders and interferon (IFN) imm...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-03-01
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| Series: | Interdisciplinary Medicine |
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| Online Access: | https://doi.org/10.1002/INMD.20240075 |
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| _version_ | 1850088657114890240 |
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| author | Haiyan Zhou Chunyan Liu Yuerong Zhang Hui Zheng |
| author_facet | Haiyan Zhou Chunyan Liu Yuerong Zhang Hui Zheng |
| author_sort | Haiyan Zhou |
| collection | DOAJ |
| description | Abstract Metabolic diseases, including obesity, diabetes, and metabolic‐associated fatty liver disease (MAFLD), are increasingly common worldwide, posing a significant public health challenge. Recent research has revealed a complex interplay between these metabolic disorders and interferon (IFN) immune responses. As key immune regulators, interferons coordinate the host's defense against viral infections and are essential for maintaining immune homeostasis. However, metabolic dysregulation can significantly disrupt IFN signaling pathways, affecting the intensity and efficiency of immune responses. Conversely, alterations in IFN signaling can influence the onset and progression of metabolic diseases. This review explores the mechanisms by which metabolic diseases modulate IFN responses, focusing on how obesity, diabetes, and MAFLD alter IFN signaling. Additionally, we examine the implications of the changes in IFN immune responses for the progression of metabolic diseases. By synthesizing current research, this review aims to elucidate the interplay between IFN immune responses and common metabolic diseases, offering insights for future research and clinical applications in the field of IFN‐related metabolic diseases. |
| format | Article |
| id | doaj-art-6479cecd7bc14a689fd1d895aa6974d2 |
| institution | DOAJ |
| issn | 2832-6245 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Interdisciplinary Medicine |
| spelling | doaj-art-6479cecd7bc14a689fd1d895aa6974d22025-08-20T02:42:58ZengWiley-VCHInterdisciplinary Medicine2832-62452025-03-0132n/an/a10.1002/INMD.20240075Metabolic diseases and interferon immune responsesHaiyan Zhou0Chunyan Liu1Yuerong Zhang2Hui Zheng3Department of Laboratory Medicine Institute of Laboratory Medicine Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu ChinaSchool of Medicine University of Electronic Science and Technology of China Chengdu ChinaDepartment of Laboratory Medicine Institute of Laboratory Medicine Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu ChinaDepartment of Laboratory Medicine Institute of Laboratory Medicine Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu ChinaAbstract Metabolic diseases, including obesity, diabetes, and metabolic‐associated fatty liver disease (MAFLD), are increasingly common worldwide, posing a significant public health challenge. Recent research has revealed a complex interplay between these metabolic disorders and interferon (IFN) immune responses. As key immune regulators, interferons coordinate the host's defense against viral infections and are essential for maintaining immune homeostasis. However, metabolic dysregulation can significantly disrupt IFN signaling pathways, affecting the intensity and efficiency of immune responses. Conversely, alterations in IFN signaling can influence the onset and progression of metabolic diseases. This review explores the mechanisms by which metabolic diseases modulate IFN responses, focusing on how obesity, diabetes, and MAFLD alter IFN signaling. Additionally, we examine the implications of the changes in IFN immune responses for the progression of metabolic diseases. By synthesizing current research, this review aims to elucidate the interplay between IFN immune responses and common metabolic diseases, offering insights for future research and clinical applications in the field of IFN‐related metabolic diseases.https://doi.org/10.1002/INMD.20240075diabetesimmune responseinterferonmetabolic diseasesobesity |
| spellingShingle | Haiyan Zhou Chunyan Liu Yuerong Zhang Hui Zheng Metabolic diseases and interferon immune responses Interdisciplinary Medicine diabetes immune response interferon metabolic diseases obesity |
| title | Metabolic diseases and interferon immune responses |
| title_full | Metabolic diseases and interferon immune responses |
| title_fullStr | Metabolic diseases and interferon immune responses |
| title_full_unstemmed | Metabolic diseases and interferon immune responses |
| title_short | Metabolic diseases and interferon immune responses |
| title_sort | metabolic diseases and interferon immune responses |
| topic | diabetes immune response interferon metabolic diseases obesity |
| url | https://doi.org/10.1002/INMD.20240075 |
| work_keys_str_mv | AT haiyanzhou metabolicdiseasesandinterferonimmuneresponses AT chunyanliu metabolicdiseasesandinterferonimmuneresponses AT yuerongzhang metabolicdiseasesandinterferonimmuneresponses AT huizheng metabolicdiseasesandinterferonimmuneresponses |