The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
Substance dependence or addiction is a complex environmental and genetic disorder that results in serious health and socio-economic consequences. Multiple substance dependence categories together, rather than any one individual addiction outcome, may explain the genetic variability of such disorder....
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016002&type=printable |
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| _version_ | 1849336656361947136 |
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| author | Xiang Chen Kelly Cho Burton H Singer Heping Zhang |
| author_facet | Xiang Chen Kelly Cho Burton H Singer Heping Zhang |
| author_sort | Xiang Chen |
| collection | DOAJ |
| description | Substance dependence or addiction is a complex environmental and genetic disorder that results in serious health and socio-economic consequences. Multiple substance dependence categories together, rather than any one individual addiction outcome, may explain the genetic variability of such disorder. In our study, we defined a composite substance dependence phenotype derived from six individual diagnoses: addiction to nicotine, alcohol, marijuana, cocaine, opiates or other drugs as a whole. Using data from several genomewide case-control studies, we identified a strong (Odds ratio = 1.77) and significant (p-value = 7E-8) association signal with a novel gene, PBX/knotted 1 homeobox 2 (PKNOX2), on chromosome 11 with the composite phenotype in European-origin women. The association signal is not as significant when individual outcomes for addiction are considered, or in males or African-origin population. Our findings underscore the importance of considering multiple addiction types and the importance of considering population and gender stratification when analyzing data with heterogeneous population. |
| format | Article |
| id | doaj-art-6472ed024376496dbec76faee31ee984 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-6472ed024376496dbec76faee31ee9842025-08-20T03:44:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0161e1600210.1371/journal.pone.0016002The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.Xiang ChenKelly ChoBurton H SingerHeping ZhangSubstance dependence or addiction is a complex environmental and genetic disorder that results in serious health and socio-economic consequences. Multiple substance dependence categories together, rather than any one individual addiction outcome, may explain the genetic variability of such disorder. In our study, we defined a composite substance dependence phenotype derived from six individual diagnoses: addiction to nicotine, alcohol, marijuana, cocaine, opiates or other drugs as a whole. Using data from several genomewide case-control studies, we identified a strong (Odds ratio = 1.77) and significant (p-value = 7E-8) association signal with a novel gene, PBX/knotted 1 homeobox 2 (PKNOX2), on chromosome 11 with the composite phenotype in European-origin women. The association signal is not as significant when individual outcomes for addiction are considered, or in males or African-origin population. Our findings underscore the importance of considering multiple addiction types and the importance of considering population and gender stratification when analyzing data with heterogeneous population.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016002&type=printable |
| spellingShingle | Xiang Chen Kelly Cho Burton H Singer Heping Zhang The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women. PLoS ONE |
| title | The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women. |
| title_full | The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women. |
| title_fullStr | The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women. |
| title_full_unstemmed | The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women. |
| title_short | The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women. |
| title_sort | nuclear transcription factor pknox2 is a candidate gene for substance dependence in european origin women |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016002&type=printable |
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