Dysregulation of Mitochondrial Homeostasis in Cardiovascular Diseases
Mitochondria dysfunction plays a central role in the development of vascular diseases as oxidative stress promotes alterations in mitochondrial morphology and function that contribute to disease progression. Redox imbalances can affect normal cellular processes including mitochondrial biogenesis, el...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/18/1/112 |
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| _version_ | 1832587711793332224 |
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| author | Ricky Patil Hui Wang Matthew Kazaleh Gorav Ailawadi Morgan Salmon |
| author_facet | Ricky Patil Hui Wang Matthew Kazaleh Gorav Ailawadi Morgan Salmon |
| author_sort | Ricky Patil |
| collection | DOAJ |
| description | Mitochondria dysfunction plays a central role in the development of vascular diseases as oxidative stress promotes alterations in mitochondrial morphology and function that contribute to disease progression. Redox imbalances can affect normal cellular processes including mitochondrial biogenesis, electrochemical equilibrium, and the regulation of mitochondrial DNA. In this review, we will discuss these imbalances and, in particular, the potential role of mitochondrial fusion, fission, biogenesis, and mitophagy in the context of vascular diseases and how the dysregulation of normal function might contribute to disease progression. We will also discuss potential implications of targeting mitochondrial regulation as therapeutic targets to treat vascular disease formation. |
| format | Article |
| id | doaj-art-646fbf6bf3414969a1ed3dbf40aa0dc3 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-646fbf6bf3414969a1ed3dbf40aa0dc32025-01-24T13:45:26ZengMDPI AGPharmaceuticals1424-82472025-01-0118111210.3390/ph18010112Dysregulation of Mitochondrial Homeostasis in Cardiovascular DiseasesRicky Patil0Hui Wang1Matthew Kazaleh2Gorav Ailawadi3Morgan Salmon4Department of Cardiac Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USADepartment of Cardiac Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USADepartment of Cardiac Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USADepartment of Cardiac Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USADepartment of Cardiac Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USAMitochondria dysfunction plays a central role in the development of vascular diseases as oxidative stress promotes alterations in mitochondrial morphology and function that contribute to disease progression. Redox imbalances can affect normal cellular processes including mitochondrial biogenesis, electrochemical equilibrium, and the regulation of mitochondrial DNA. In this review, we will discuss these imbalances and, in particular, the potential role of mitochondrial fusion, fission, biogenesis, and mitophagy in the context of vascular diseases and how the dysregulation of normal function might contribute to disease progression. We will also discuss potential implications of targeting mitochondrial regulation as therapeutic targets to treat vascular disease formation.https://www.mdpi.com/1424-8247/18/1/112mitochondriaaortic aneurysmmurine modelelastasecardiac surgeryaorta |
| spellingShingle | Ricky Patil Hui Wang Matthew Kazaleh Gorav Ailawadi Morgan Salmon Dysregulation of Mitochondrial Homeostasis in Cardiovascular Diseases Pharmaceuticals mitochondria aortic aneurysm murine model elastase cardiac surgery aorta |
| title | Dysregulation of Mitochondrial Homeostasis in Cardiovascular Diseases |
| title_full | Dysregulation of Mitochondrial Homeostasis in Cardiovascular Diseases |
| title_fullStr | Dysregulation of Mitochondrial Homeostasis in Cardiovascular Diseases |
| title_full_unstemmed | Dysregulation of Mitochondrial Homeostasis in Cardiovascular Diseases |
| title_short | Dysregulation of Mitochondrial Homeostasis in Cardiovascular Diseases |
| title_sort | dysregulation of mitochondrial homeostasis in cardiovascular diseases |
| topic | mitochondria aortic aneurysm murine model elastase cardiac surgery aorta |
| url | https://www.mdpi.com/1424-8247/18/1/112 |
| work_keys_str_mv | AT rickypatil dysregulationofmitochondrialhomeostasisincardiovasculardiseases AT huiwang dysregulationofmitochondrialhomeostasisincardiovasculardiseases AT matthewkazaleh dysregulationofmitochondrialhomeostasisincardiovasculardiseases AT goravailawadi dysregulationofmitochondrialhomeostasisincardiovasculardiseases AT morgansalmon dysregulationofmitochondrialhomeostasisincardiovasculardiseases |