Night shift work, poor sleep quality and unhealthy sleep behaviors are positively associated with the risk of epilepsy disease
Abstract Background Night shift work and poor sleep quality are gradually becoming more prevalent in modern society. Nevertheless, there have been limited studies assessing the association between night shift work, sleep behaviors, and risk of epilepsy. The aim of our study was to ascertain whether...
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BMC
2024-11-01
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| Online Access: | https://doi.org/10.1186/s12889-024-20885-z |
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| author | Xushuai Dong Huiling Liu Zhiheng Huang Kaidi Liu Rui Zhang Shicheng Sun Bin Feng Hua Guo Shaobin Feng |
| author_facet | Xushuai Dong Huiling Liu Zhiheng Huang Kaidi Liu Rui Zhang Shicheng Sun Bin Feng Hua Guo Shaobin Feng |
| author_sort | Xushuai Dong |
| collection | DOAJ |
| description | Abstract Background Night shift work and poor sleep quality are gradually becoming more prevalent in modern society. Nevertheless, there have been limited studies assessing the association between night shift work, sleep behaviors, and risk of epilepsy. The aim of our study was to ascertain whether a positive association exists between night shift work, sleep quality, sleep behaviors, and risk of epilepsy. Methods Our study included a total of over 270,000 individuals with or without epilepsy from the UK Biobank, followed up over a period of 13.5 years. Information on current night shift work and major sleep behaviors was also obtained. We used Cox proportional hazard models to assess the association between night shift work, sleep quality, sleep behaviors, and the risk of epilepsy after adjusting for multiple variables. Results Night shift work was positively associated with a higher risk of epilepsy (P for trend = 0.059). There was a gradual increase in epilepsy risk from ‘never/rarely’ to ‘usual/permanent’ night shifts, with ‘usual/permanent’ night shifts work presenting the highest risk [hazard ratio (HR) 1.29, 95% confidence interval (CI) 1.01–1.65). Additionally, there was a significant association between sleep quality and risk of epilepsy (P < 0.001). Among the five major sleep behaviors, sleep duration (< 7 or > 8 h/day), frequent insomnia, and daytime sleepiness were significantly associated with a higher risk of epilepsy (HR 1.19, 95% CI 1.11–1.28; HR 1.19, 95% CI 1.09–1.30; HR 1.46, 95% CI 1.24–1.72, respectively). Furthermore, sleep duration exhibited a ‘U-shaped’ association with epilepsy risk. Nevertheless, no significant association was found between sleep chronotype and snoring and the risk of incident epilepsy (HR 1.04, 95% CI 0.96–1.12; HR 0.96, 95% CI 0.89–1.04). Conclusions ‘Usual/permanent’ night shifts and poor sleep quality were positively associated with a greater risk of incident epilepsy. Major sleep behaviors, including unhealthy sleep duration (< 7 or > 8 h/day), frequent insomnia, and daytime sleepiness, also tended to increase the risk of epilepsy. |
| format | Article |
| id | doaj-art-646f45b9f61742b9b000be1873d41864 |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-646f45b9f61742b9b000be1873d418642024-12-01T12:48:47ZengBMCBMC Public Health1471-24582024-11-0124111010.1186/s12889-024-20885-zNight shift work, poor sleep quality and unhealthy sleep behaviors are positively associated with the risk of epilepsy diseaseXushuai Dong0Huiling Liu1Zhiheng Huang2Kaidi Liu3Rui Zhang4Shicheng Sun5Bin Feng6Hua Guo7Shaobin Feng8Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityAbstract Background Night shift work and poor sleep quality are gradually becoming more prevalent in modern society. Nevertheless, there have been limited studies assessing the association between night shift work, sleep behaviors, and risk of epilepsy. The aim of our study was to ascertain whether a positive association exists between night shift work, sleep quality, sleep behaviors, and risk of epilepsy. Methods Our study included a total of over 270,000 individuals with or without epilepsy from the UK Biobank, followed up over a period of 13.5 years. Information on current night shift work and major sleep behaviors was also obtained. We used Cox proportional hazard models to assess the association between night shift work, sleep quality, sleep behaviors, and the risk of epilepsy after adjusting for multiple variables. Results Night shift work was positively associated with a higher risk of epilepsy (P for trend = 0.059). There was a gradual increase in epilepsy risk from ‘never/rarely’ to ‘usual/permanent’ night shifts, with ‘usual/permanent’ night shifts work presenting the highest risk [hazard ratio (HR) 1.29, 95% confidence interval (CI) 1.01–1.65). Additionally, there was a significant association between sleep quality and risk of epilepsy (P < 0.001). Among the five major sleep behaviors, sleep duration (< 7 or > 8 h/day), frequent insomnia, and daytime sleepiness were significantly associated with a higher risk of epilepsy (HR 1.19, 95% CI 1.11–1.28; HR 1.19, 95% CI 1.09–1.30; HR 1.46, 95% CI 1.24–1.72, respectively). Furthermore, sleep duration exhibited a ‘U-shaped’ association with epilepsy risk. Nevertheless, no significant association was found between sleep chronotype and snoring and the risk of incident epilepsy (HR 1.04, 95% CI 0.96–1.12; HR 0.96, 95% CI 0.89–1.04). Conclusions ‘Usual/permanent’ night shifts and poor sleep quality were positively associated with a greater risk of incident epilepsy. Major sleep behaviors, including unhealthy sleep duration (< 7 or > 8 h/day), frequent insomnia, and daytime sleepiness, also tended to increase the risk of epilepsy.https://doi.org/10.1186/s12889-024-20885-zNight shiftSleep qualitySleep behaviorsSleep durationInsomniaDaytime sleepiness |
| spellingShingle | Xushuai Dong Huiling Liu Zhiheng Huang Kaidi Liu Rui Zhang Shicheng Sun Bin Feng Hua Guo Shaobin Feng Night shift work, poor sleep quality and unhealthy sleep behaviors are positively associated with the risk of epilepsy disease BMC Public Health Night shift Sleep quality Sleep behaviors Sleep duration Insomnia Daytime sleepiness |
| title | Night shift work, poor sleep quality and unhealthy sleep behaviors are positively associated with the risk of epilepsy disease |
| title_full | Night shift work, poor sleep quality and unhealthy sleep behaviors are positively associated with the risk of epilepsy disease |
| title_fullStr | Night shift work, poor sleep quality and unhealthy sleep behaviors are positively associated with the risk of epilepsy disease |
| title_full_unstemmed | Night shift work, poor sleep quality and unhealthy sleep behaviors are positively associated with the risk of epilepsy disease |
| title_short | Night shift work, poor sleep quality and unhealthy sleep behaviors are positively associated with the risk of epilepsy disease |
| title_sort | night shift work poor sleep quality and unhealthy sleep behaviors are positively associated with the risk of epilepsy disease |
| topic | Night shift Sleep quality Sleep behaviors Sleep duration Insomnia Daytime sleepiness |
| url | https://doi.org/10.1186/s12889-024-20885-z |
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