Influence of glucoregulation quality on c-reactive protein, interleukin-6 and tumor necrosis factor-α level in patients with diabetes type 1
Background/Aim. Results of studies which have proved an increased inflammatory activity in diabetes type 1, have been published over recent years. One of possible mechanisms that are used to explain chronic inflammation in diabetes is the state of hyperglycemia leading to the enhanced synthesis...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2011-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501109756M.pdf |
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| author | Mitrović Milena Ilić Tatjana Stokić Edita Novaković-Paro Jovanka Tomić-Naglić Dragana Bajkin Ivana Ičin Tijana |
| author_facet | Mitrović Milena Ilić Tatjana Stokić Edita Novaković-Paro Jovanka Tomić-Naglić Dragana Bajkin Ivana Ičin Tijana |
| author_sort | Mitrović Milena |
| collection | DOAJ |
| description | Background/Aim. Results of studies which have proved an increased inflammatory activity in diabetes type 1, have been published over recent years. One of possible mechanisms that are used to explain chronic inflammation in diabetes is the state of hyperglycemia leading to the enhanced synthesis of glycosylation end products (AGEs) which activate macrophages, increase the oxidative stress and affect the synthesis of interleukins (IL-1, IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP). The aim of the study was to determine the inflammatory markers (CRP, IL-6, TNF-α) in patients with diabetes type 1 and to establish their correlation with glucoregulation parameters and other cardiovascular risk factors as well as to compare them with the healthy controls. Methods. The study included 76 patients with diabetes type 1 and 30 healthy controls. We determined values of inflammatory markers (CRP, IL-6, TNF-α) and glucoregulation parameters (fasting glucose HbA1c). Results. The values of CRP (p = 0.014), IL-6 (p = 0.020) and TNF-α (p = 0.037) were statistically significantly higher in the diabetic patients than in the healthy controls. There was a positive correlation between CRP with postprandial glycemia (p = 0.004); the multivariate regression analysis revealed a statistically significant correlation between CRP and age (p = 0.001), smoking (p = 0.055), fasting glucose (p = 0.021) and triglycerides (p = 0.048) as well as between IL-6 and LDLcholesterol (p = 0,009). No statistically significant correlations were found between glycosilated hemoglobin (HbA1c) and the inflammatory markers (CRP, IL-6 and TNF-α). Conclusion. The patients with type 1 diabetes were found to have a low level of inflammatory activity manifested by the increased values of CRP, IL-6 and TNF-α. |
| format | Article |
| id | doaj-art-646d4e65480144fb8777ca18a0ee3cf9 |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-646d4e65480144fb8777ca18a0ee3cf92025-08-20T02:23:52ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502011-01-0168975676110.2298/VSP1109756MInfluence of glucoregulation quality on c-reactive protein, interleukin-6 and tumor necrosis factor-α level in patients with diabetes type 1Mitrović MilenaIlić TatjanaStokić EditaNovaković-Paro JovankaTomić-Naglić DraganaBajkin IvanaIčin TijanaBackground/Aim. Results of studies which have proved an increased inflammatory activity in diabetes type 1, have been published over recent years. One of possible mechanisms that are used to explain chronic inflammation in diabetes is the state of hyperglycemia leading to the enhanced synthesis of glycosylation end products (AGEs) which activate macrophages, increase the oxidative stress and affect the synthesis of interleukins (IL-1, IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP). The aim of the study was to determine the inflammatory markers (CRP, IL-6, TNF-α) in patients with diabetes type 1 and to establish their correlation with glucoregulation parameters and other cardiovascular risk factors as well as to compare them with the healthy controls. Methods. The study included 76 patients with diabetes type 1 and 30 healthy controls. We determined values of inflammatory markers (CRP, IL-6, TNF-α) and glucoregulation parameters (fasting glucose HbA1c). Results. The values of CRP (p = 0.014), IL-6 (p = 0.020) and TNF-α (p = 0.037) were statistically significantly higher in the diabetic patients than in the healthy controls. There was a positive correlation between CRP with postprandial glycemia (p = 0.004); the multivariate regression analysis revealed a statistically significant correlation between CRP and age (p = 0.001), smoking (p = 0.055), fasting glucose (p = 0.021) and triglycerides (p = 0.048) as well as between IL-6 and LDLcholesterol (p = 0,009). No statistically significant correlations were found between glycosilated hemoglobin (HbA1c) and the inflammatory markers (CRP, IL-6 and TNF-α). Conclusion. The patients with type 1 diabetes were found to have a low level of inflammatory activity manifested by the increased values of CRP, IL-6 and TNF-α.http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501109756M.pdfdiabetes mellitus, type 1blood glucosec-reactive proteininterleukin-6tumor necrosis factor-alphasensitivity and specificity |
| spellingShingle | Mitrović Milena Ilić Tatjana Stokić Edita Novaković-Paro Jovanka Tomić-Naglić Dragana Bajkin Ivana Ičin Tijana Influence of glucoregulation quality on c-reactive protein, interleukin-6 and tumor necrosis factor-α level in patients with diabetes type 1 Vojnosanitetski Pregled diabetes mellitus, type 1 blood glucose c-reactive protein interleukin-6 tumor necrosis factor-alpha sensitivity and specificity |
| title | Influence of glucoregulation quality on c-reactive protein, interleukin-6 and tumor necrosis factor-α level in patients with diabetes type 1 |
| title_full | Influence of glucoregulation quality on c-reactive protein, interleukin-6 and tumor necrosis factor-α level in patients with diabetes type 1 |
| title_fullStr | Influence of glucoregulation quality on c-reactive protein, interleukin-6 and tumor necrosis factor-α level in patients with diabetes type 1 |
| title_full_unstemmed | Influence of glucoregulation quality on c-reactive protein, interleukin-6 and tumor necrosis factor-α level in patients with diabetes type 1 |
| title_short | Influence of glucoregulation quality on c-reactive protein, interleukin-6 and tumor necrosis factor-α level in patients with diabetes type 1 |
| title_sort | influence of glucoregulation quality on c reactive protein interleukin 6 and tumor necrosis factor α level in patients with diabetes type 1 |
| topic | diabetes mellitus, type 1 blood glucose c-reactive protein interleukin-6 tumor necrosis factor-alpha sensitivity and specificity |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501109756M.pdf |
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