Role of the JC Polyomavirus (JCV) and BK Polyomavirus (BKV) in the colorectal cancer of some Egyptian patients
Although several cases and case-control studies reported the prevalence of JC polyomavirus (JCV) and BK polyomavirus (BKV) in tumor tissues of colorectal cancer (CRC) patients as well as in control samples; however, many recent studies did not show the prevalence of these viruses in the CRC patien...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
ResearchersLinks, Ltd
2020-02-01
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| Series: | Novel Research in Microbiology Journal |
| Subjects: | |
| Online Access: | https://nrmj.journals.ekb.eg/article_73428_f5761b28b6332608d94dd2e51bd8daf6.pdf |
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| Summary: | Although several cases and case-control studies reported the prevalence of JC polyomavirus (JCV) and BK
polyomavirus (BKV) in tumor tissues of colorectal cancer (CRC) patients as well as in control samples; however,
many recent studies did not show the prevalence of these viruses in the CRC patients. A total of 50 clinical
biopsies samples were collected from patients with and without CRC in the General surgery department, Faculty
of Medicine, Ain Shams University, Egypt, with the approval of the research ethics committee. Current results
showed the absence of the genomic DNA of both JCV and BKV in the tumor tissue samples, adjacent-tumor
normal mucosa samples from CRC patients, and also in the normal mucosa samples collected from the non-CRC
patients. Moreover, results of the semi-nested PCR and real-time PCR are similar, and confirmed that JCV and
BKV are not prevalent in the Egyptian CRC patients. There are no promising results for further investigation of
the expression of the large T-Ag protein, and any other related proteins in the tumor cells. Based on the present
results, no evidence supports the association between the JCV, BKV and CRC in the Egyptian patients. For the
best of our knowledge, this is the first case-control study on the prevalence of JCV and BKV in the Egyptian CRC
patients. The aim of the current study was to detect the presence of JCV and BKV genomic DNA in the tissue
samples, to support further studies on the role of these viruses in the CRC etiology and development. |
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| ISSN: | 2537-0286 2537-0294 |