Visual Outcomes and Safety Profile of “Dropless Vitrectomy” for Epiretinal Membranes
Kakarla V Chalam,1 Anny MS Cheng,2– 4 Suzie Gasparian1 1Department of Ophthalmology, Loma Linda University, Loma Linda, CA, USA; 2Department of Ophthalmology, Broward Health, Fort Lauderdale, FL, USA; 3Department of Ophthalmology, Specialty Retina Center, Deerfield Beach, FL, USA; 4Department of Oph...
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Dove Medical Press
2025-06-01
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| author | Chalam KV Cheng AMS Gasparian S |
| author_facet | Chalam KV Cheng AMS Gasparian S |
| author_sort | Chalam KV |
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| description | Kakarla V Chalam,1 Anny MS Cheng,2– 4 Suzie Gasparian1 1Department of Ophthalmology, Loma Linda University, Loma Linda, CA, USA; 2Department of Ophthalmology, Broward Health, Fort Lauderdale, FL, USA; 3Department of Ophthalmology, Specialty Retina Center, Deerfield Beach, FL, USA; 4Department of Ophthalmology, University of Florida, Gainesville, FL, USACorrespondence: Kakarla V Chalam, Department of Ophthalmology, Loma Linda University, 11370 Anderson St., Suite 1800, Loma Linda, CA, 92354, USA, Tel +1 904 403-2607, Email kakarla.chalam@gmail.comPurpose: To assess the clinical effectiveness and safety of Tri-Moxi intravitreal injection in comparison to standard postoperative topical steroid-antibiotic treatment after epiretinal membrane (ERM) removal with pars plana vitrectomy (PPV).Methods: A retrospective longitudinal cohort study of 278 eyes undergoing ERM removal by PPV was conducted from 2019 to 2023. Group 1 (N = 139) received a triamcinolone acetonide–moxifloxacin (Tri-Moxi) intravitreal injection at the conclusion of surgery, and Group 2 (N = 139) had postoperative standard topical antibiotic-steroid therapy. Clinical changes of best-corrected visual acuity (BCVA), intraocular pressure (IOP), and central foveal thickness (CFT) were evaluated.Results: By 3-month after surgery, the Tri-Moxi (Group 1) demonstrated a significantly greater reduction in CFT (178 ± 32 vs 145 ± 38 μm, P < 0.001) and a slightly superior improvement in BCVA (0.34 ± 0.03 vs 0.41 ± 0.04 logMAR, P < 0.05) compared to the standard (Group 2). Postoperative IOP remained minimal change in both groups. The occurrence of cystoid macular edema was markedly reduced in patients receiving Tri-Moxi (4% vs 10%, P = 0.02). No infection or ocular hypertension cases were recorded.Conclusion: For the postoperative management of PPV in ERM patients, intravitreal Tri-Moxi injection is an efficacious and safe alternative to standard topical therapy. Intravitreal Tri-Moxi can be used as a viable treatment option for managing inflammation and preventing infection after epiretinal membrane removal by pars plana vitrectomy. Tri-Moxi group demonstrated superior anatomical outcomes and comparable functional outcomes while simplifying postoperative care and reducing the occurrence of cystoid macular edema compared to standard topical therapy.Keywords: central macular edema, drop less, epiretinal membrane, inflammation, moxifloxacin, triamcinolone acetonide, vitrectomy surgery, wound healing |
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| institution | Kabale University |
| issn | 1177-5483 |
| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-645e4ac40d3d47e6aae84591c75ead1c2025-08-20T03:29:52ZengDove Medical PressClinical Ophthalmology1177-54832025-06-01Volume 19Issue 119651974104162Visual Outcomes and Safety Profile of &ldquo;Dropless Vitrectomy&rdquo; for Epiretinal MembranesChalam KV0Cheng AMS1Gasparian S2OphthalmologyOphthalmologyOphthalmologyKakarla V Chalam,1 Anny MS Cheng,2– 4 Suzie Gasparian1 1Department of Ophthalmology, Loma Linda University, Loma Linda, CA, USA; 2Department of Ophthalmology, Broward Health, Fort Lauderdale, FL, USA; 3Department of Ophthalmology, Specialty Retina Center, Deerfield Beach, FL, USA; 4Department of Ophthalmology, University of Florida, Gainesville, FL, USACorrespondence: Kakarla V Chalam, Department of Ophthalmology, Loma Linda University, 11370 Anderson St., Suite 1800, Loma Linda, CA, 92354, USA, Tel +1 904 403-2607, Email kakarla.chalam@gmail.comPurpose: To assess the clinical effectiveness and safety of Tri-Moxi intravitreal injection in comparison to standard postoperative topical steroid-antibiotic treatment after epiretinal membrane (ERM) removal with pars plana vitrectomy (PPV).Methods: A retrospective longitudinal cohort study of 278 eyes undergoing ERM removal by PPV was conducted from 2019 to 2023. Group 1 (N = 139) received a triamcinolone acetonide–moxifloxacin (Tri-Moxi) intravitreal injection at the conclusion of surgery, and Group 2 (N = 139) had postoperative standard topical antibiotic-steroid therapy. Clinical changes of best-corrected visual acuity (BCVA), intraocular pressure (IOP), and central foveal thickness (CFT) were evaluated.Results: By 3-month after surgery, the Tri-Moxi (Group 1) demonstrated a significantly greater reduction in CFT (178 ± 32 vs 145 ± 38 μm, P < 0.001) and a slightly superior improvement in BCVA (0.34 ± 0.03 vs 0.41 ± 0.04 logMAR, P < 0.05) compared to the standard (Group 2). Postoperative IOP remained minimal change in both groups. The occurrence of cystoid macular edema was markedly reduced in patients receiving Tri-Moxi (4% vs 10%, P = 0.02). No infection or ocular hypertension cases were recorded.Conclusion: For the postoperative management of PPV in ERM patients, intravitreal Tri-Moxi injection is an efficacious and safe alternative to standard topical therapy. Intravitreal Tri-Moxi can be used as a viable treatment option for managing inflammation and preventing infection after epiretinal membrane removal by pars plana vitrectomy. Tri-Moxi group demonstrated superior anatomical outcomes and comparable functional outcomes while simplifying postoperative care and reducing the occurrence of cystoid macular edema compared to standard topical therapy.Keywords: central macular edema, drop less, epiretinal membrane, inflammation, moxifloxacin, triamcinolone acetonide, vitrectomy surgery, wound healinghttps://www.dovepress.com/visual-outcomes-and-safety-profile-of-dropless-vitrectomy-for-epiretin-peer-reviewed-fulltext-article-OPTHCentral macular edemaDrop lessEpiretinal membraneinflammationmoxifloxacintriamcinolone acetonide |
| spellingShingle | Chalam KV Cheng AMS Gasparian S Visual Outcomes and Safety Profile of &ldquo;Dropless Vitrectomy&rdquo; for Epiretinal Membranes Clinical Ophthalmology Central macular edema Drop less Epiretinal membrane inflammation moxifloxacin triamcinolone acetonide |
| title | Visual Outcomes and Safety Profile of &ldquo;Dropless Vitrectomy&rdquo; for Epiretinal Membranes |
| title_full | Visual Outcomes and Safety Profile of &ldquo;Dropless Vitrectomy&rdquo; for Epiretinal Membranes |
| title_fullStr | Visual Outcomes and Safety Profile of &ldquo;Dropless Vitrectomy&rdquo; for Epiretinal Membranes |
| title_full_unstemmed | Visual Outcomes and Safety Profile of &ldquo;Dropless Vitrectomy&rdquo; for Epiretinal Membranes |
| title_short | Visual Outcomes and Safety Profile of &ldquo;Dropless Vitrectomy&rdquo; for Epiretinal Membranes |
| title_sort | visual outcomes and safety profile of amp ldquo dropless vitrectomy amp rdquo for epiretinal membranes |
| topic | Central macular edema Drop less Epiretinal membrane inflammation moxifloxacin triamcinolone acetonide |
| url | https://www.dovepress.com/visual-outcomes-and-safety-profile-of-dropless-vitrectomy-for-epiretin-peer-reviewed-fulltext-article-OPTH |
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