Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C
Objectives. We evaluated platelet counts in end-stage renal disease and chronic viral hepatitis. Materials and Methods. We studied 70 patients with end-stage renal disease and chronic viral hepatitis and compared them to a control group of 45 patients without hepatitis. Results. The presence of v...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Journal of Mind and Medical Sciences |
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| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1124&context=jmms |
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| author | Olga Hilda Orasan Laura Urian George Ciulei Iulia Breaban Andreea Maria Stefan Sorina Cezara Secara Adela-Sitar Taut Simina Tarmure Sarlea Vasile Negrean Dorel Sampelean Ioan Mihai Patiu Remus Aurel Orasan Angela Cozma |
| author_facet | Olga Hilda Orasan Laura Urian George Ciulei Iulia Breaban Andreea Maria Stefan Sorina Cezara Secara Adela-Sitar Taut Simina Tarmure Sarlea Vasile Negrean Dorel Sampelean Ioan Mihai Patiu Remus Aurel Orasan Angela Cozma |
| author_sort | Olga Hilda Orasan |
| collection | DOAJ |
| description | Objectives. We evaluated platelet counts in end-stage renal disease and chronic viral hepatitis.
Materials and Methods. We studied 70 patients with end-stage renal disease and chronic viral hepatitis and compared them to a control group of 45 patients without hepatitis.
Results. The presence of viral hepatitis was associated with a higher prevalence of thrombocytopenia. Correlations between age, C-reactive protein, liver stiffness measurement, and platelet count were observed. C-reactive protein levels > 10 mg/dl were associated with a lower risk of thrombocytopenia in patients with end-stage renal disease and chronic viral hepatitis, yet age > 60 years, dialysis vintage > 10 years, aspartate and alanine aminotransferase levels > 20 IU/L, albumin levels < 3.5 g/dl, and fibrosis stage ≥ 3 were not related.
Conclusions. Chronic viral hepatitis leads to a higher prevalence of thrombocytopenia. Platelet counts in these patients begin to decrease significantly once liver fibrosis reaches stage III. |
| format | Article |
| id | doaj-art-645772ebeea54dcb8fc33930ae9b9b7b |
| institution | OA Journals |
| issn | 2392-7674 2392-7674 |
| language | English |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj-art-645772ebeea54dcb8fc33930ae9b9b7b2025-08-20T01:51:02ZengMDPI AGJournal of Mind and Medical Sciences2392-76742392-76742018-10-015223624310.22543/7674.52.P236243Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or COlga Hilda Orasan0Laura Urian1George Ciulei2Iulia Breaban3Andreea Maria Stefan4Sorina Cezara Secara5Adela-Sitar Taut6Simina Tarmure Sarlea7Vasile Negrean8Dorel Sampelean9Ioan Mihai Patiu10Remus Aurel Orasan11Angela Cozma12Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Medical Department, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Department of Hematology, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Medical Department, Cluj-Napoca, RomaniaRegional Institute of Gastroenterology and Hepatology- Prof. Dr. Octavian Fodor, Cluj-Napoca, Romania Regional Institute of Gastroenterology and Hepatology- Prof. Dr. Octavian Fodor, Cluj-Napoca, RomaniaRegional Institute of Gastroenterology and Hepatology- Prof. Dr. Octavian Fodor, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Medical Department, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Medical Department, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Medical Department, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Medical Department, Cluj-Napoca, RomaniaNefromed Dialysis Centers, Cluj-Napoca, RomaniaNefromed Dialysis Centers, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Medical Department, Cluj-Napoca, RomaniaObjectives. We evaluated platelet counts in end-stage renal disease and chronic viral hepatitis. Materials and Methods. We studied 70 patients with end-stage renal disease and chronic viral hepatitis and compared them to a control group of 45 patients without hepatitis. Results. The presence of viral hepatitis was associated with a higher prevalence of thrombocytopenia. Correlations between age, C-reactive protein, liver stiffness measurement, and platelet count were observed. C-reactive protein levels > 10 mg/dl were associated with a lower risk of thrombocytopenia in patients with end-stage renal disease and chronic viral hepatitis, yet age > 60 years, dialysis vintage > 10 years, aspartate and alanine aminotransferase levels > 20 IU/L, albumin levels < 3.5 g/dl, and fibrosis stage ≥ 3 were not related. Conclusions. Chronic viral hepatitis leads to a higher prevalence of thrombocytopenia. Platelet counts in these patients begin to decrease significantly once liver fibrosis reaches stage III.https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1124&context=jmmsthrombocytopeniaend-stage renal diseasechronic viral hepatitis |
| spellingShingle | Olga Hilda Orasan Laura Urian George Ciulei Iulia Breaban Andreea Maria Stefan Sorina Cezara Secara Adela-Sitar Taut Simina Tarmure Sarlea Vasile Negrean Dorel Sampelean Ioan Mihai Patiu Remus Aurel Orasan Angela Cozma Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C Journal of Mind and Medical Sciences thrombocytopenia end-stage renal disease chronic viral hepatitis |
| title | Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C |
| title_full | Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C |
| title_fullStr | Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C |
| title_full_unstemmed | Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C |
| title_short | Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C |
| title_sort | thrombocytopenia in end stage renal disease and chronic viral hepatitis b or c |
| topic | thrombocytopenia end-stage renal disease chronic viral hepatitis |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1124&context=jmms |
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