Statin Intolerance and Adverse Effects in Lipid-Lowering Therapy – Pathomechanisms, Management Strategies, and Alternative Treatment Approaches

Statin Intolerance and Adverse Effects in Lipid-Lowering Therapy – Pathomechanisms, Management Strategies, and Alternative Treatment Approaches

Statins are essential in preventing cardiovascular diseases by lowering LDL cholesterol levels. Landmark trials like 4S and HPS demonstrated significant reductions in cardiovascular events and mortality with statin use. Statins inhibit hepatic cholesterol synthesis and upregulate LDL receptors, impr...

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Main Authors: Natalia Śliwa, Bartosz Dądela, Eliza Kawalska, Emilia Majewska, Szymon Gnitecki, Maciej Borowski, Szymon Janczura, Kacper Zielonka, Marcin Markowski, Joanna Jasińska
Format: Article
Language:English
Published: Nicolaus Copernicus University in Toruń 2025-06-01
Series:Quality in Sport
Subjects:
statins
HMG-CoA
Myopathy
liver disease
cholesterol
PCSK9
Online Access:https://apcz.umk.pl/QS/article/view/61202
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