Autologous Fat Grafting in the Treatment of Facial Scleroderma
Systemic sclerosis (SSc) is a rare systemic autoimmune disease, characterized by progressive cutaneous and internal organ fibrosis. Orofacial manifestations of systemic sclerosis are extremely disabling and treatment options are limited. In this study, we aimed to assess the safety and efficacy of a...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/6568016 |
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| author | Mehdi Gheisari Arman Ahmadzadeh Nilofar Nobari Behzad Iranmanesh Nikoo Mozafari |
| author_facet | Mehdi Gheisari Arman Ahmadzadeh Nilofar Nobari Behzad Iranmanesh Nikoo Mozafari |
| author_sort | Mehdi Gheisari |
| collection | DOAJ |
| description | Systemic sclerosis (SSc) is a rare systemic autoimmune disease, characterized by progressive cutaneous and internal organ fibrosis. Orofacial manifestations of systemic sclerosis are extremely disabling and treatment options are limited. In this study, we aimed to assess the safety and efficacy of autologous fat grafting in the face of patients with systemic sclerosis. We enrolled 16 SSc patients suffering from facial sclerosis and limited mouth opening capacity. Autologous fat injection ranging from 15 to 40 ml was administered per patient, based on their face morphology. The patients were evaluated at baseline and 3 months after fat injection. Evaluations included mouth opening capacity, mouth handicap in systemic sclerosis (MHISS), Rodnan skin sclerosis score, skin biophysical properties using a sensitive biometrologic device with the assessment of cutaneous resonance running time (CRRT), volumizing and aesthetic effects based on pre- and posttreatment photographs, possible side effects, and global patient satisfaction. Clinical assessment showed autologous fat transfer significantly improved mouth opening capacity and the MHISS and Rodnan score of patients with facial scleroderma (p value <.001). The aesthetic and/or functional results of fat injection were satisfying to about 80% of the patients. The changes in CRRT values were not significant. Our findings support the possible therapeutic role of autologous fat grafting in improving facial scleroderma both in aesthetic and in functional aspects. This trial is registered with IRCT20180209038677N1. |
| format | Article |
| id | doaj-art-6451893e703647c7a468e1ded8b0c737 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-6451893e703647c7a468e1ded8b0c7372025-02-03T06:06:22ZengWileyDermatology Research and Practice1687-61051687-61132018-01-01201810.1155/2018/65680166568016Autologous Fat Grafting in the Treatment of Facial SclerodermaMehdi Gheisari0Arman Ahmadzadeh1Nilofar Nobari2Behzad Iranmanesh3Nikoo Mozafari4Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Rheumatology, Shahid Beheshti University of Medical Sciences, Tehran, IranSkin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranSkin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranSkin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranSystemic sclerosis (SSc) is a rare systemic autoimmune disease, characterized by progressive cutaneous and internal organ fibrosis. Orofacial manifestations of systemic sclerosis are extremely disabling and treatment options are limited. In this study, we aimed to assess the safety and efficacy of autologous fat grafting in the face of patients with systemic sclerosis. We enrolled 16 SSc patients suffering from facial sclerosis and limited mouth opening capacity. Autologous fat injection ranging from 15 to 40 ml was administered per patient, based on their face morphology. The patients were evaluated at baseline and 3 months after fat injection. Evaluations included mouth opening capacity, mouth handicap in systemic sclerosis (MHISS), Rodnan skin sclerosis score, skin biophysical properties using a sensitive biometrologic device with the assessment of cutaneous resonance running time (CRRT), volumizing and aesthetic effects based on pre- and posttreatment photographs, possible side effects, and global patient satisfaction. Clinical assessment showed autologous fat transfer significantly improved mouth opening capacity and the MHISS and Rodnan score of patients with facial scleroderma (p value <.001). The aesthetic and/or functional results of fat injection were satisfying to about 80% of the patients. The changes in CRRT values were not significant. Our findings support the possible therapeutic role of autologous fat grafting in improving facial scleroderma both in aesthetic and in functional aspects. This trial is registered with IRCT20180209038677N1.http://dx.doi.org/10.1155/2018/6568016 |
| spellingShingle | Mehdi Gheisari Arman Ahmadzadeh Nilofar Nobari Behzad Iranmanesh Nikoo Mozafari Autologous Fat Grafting in the Treatment of Facial Scleroderma Dermatology Research and Practice |
| title | Autologous Fat Grafting in the Treatment of Facial Scleroderma |
| title_full | Autologous Fat Grafting in the Treatment of Facial Scleroderma |
| title_fullStr | Autologous Fat Grafting in the Treatment of Facial Scleroderma |
| title_full_unstemmed | Autologous Fat Grafting in the Treatment of Facial Scleroderma |
| title_short | Autologous Fat Grafting in the Treatment of Facial Scleroderma |
| title_sort | autologous fat grafting in the treatment of facial scleroderma |
| url | http://dx.doi.org/10.1155/2018/6568016 |
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