Cerebral hemodynamics: concepts of clinical importance
Cerebral hemodynamics and metabolism are frequently impaired in a wide range of neurological diseases, including traumatic brain injury and stroke, with several pathophysiological mechanisms of injury. The resultant uncoupling of cerebral blood flow and metabolism can trigger secondary brain lesions...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2012-05-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500010&lng=en&tlng=en |
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| author | Edson Bor-Seng-Shu William S. Kita Eberval G. Figueiredo Wellingson S. Paiva Erich T. Fonoff Manoel J. Teixeira Ronney B. Panerai |
| author_facet | Edson Bor-Seng-Shu William S. Kita Eberval G. Figueiredo Wellingson S. Paiva Erich T. Fonoff Manoel J. Teixeira Ronney B. Panerai |
| author_sort | Edson Bor-Seng-Shu |
| collection | DOAJ |
| description | Cerebral hemodynamics and metabolism are frequently impaired in a wide range of neurological diseases, including traumatic brain injury and stroke, with several pathophysiological mechanisms of injury. The resultant uncoupling of cerebral blood flow and metabolism can trigger secondary brain lesions, particularly in early phases, consequently worsening the patient's outcome. Cerebral blood flow regulation is influenced by blood gas content, blood viscosity, body temperature, cardiac output, altitude, cerebrovascular autoregulation, and neurovascular coupling, mediated by chemical agents such as nitric oxide (NO), carbon monoxide (CO), eicosanoid products, oxygen-derived free radicals, endothelins, K+, H+, and adenosine. A better understanding of these factors is valuable for the management of neurocritical care patients. The assessment of both cerebral hemodynamics and metabolism in the acute phase of neurocritical care conditions may contribute to a more effective planning of therapeutic strategies for reducing secondary brain lesions. In this review, the authors have discussed concepts of cerebral hemodynamics, considering aspects of clinical importance. |
| format | Article |
| id | doaj-art-64500658f1bb4801b28bc5509d3f8c8c |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publishDate | 2012-05-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-64500658f1bb4801b28bc5509d3f8c8c2025-08-20T03:34:24ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272012-05-0170535235610.1590/S0004-282X2012000500010S0004-282X2012000500010Cerebral hemodynamics: concepts of clinical importanceEdson Bor-Seng-Shu0William S. Kita1Eberval G. Figueiredo2Wellingson S. Paiva3Erich T. Fonoff4Manoel J. Teixeira5Ronney B. Panerai6Universidade de São PauloFaculty of Medicine of MaríliaUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversity of LeicesterCerebral hemodynamics and metabolism are frequently impaired in a wide range of neurological diseases, including traumatic brain injury and stroke, with several pathophysiological mechanisms of injury. The resultant uncoupling of cerebral blood flow and metabolism can trigger secondary brain lesions, particularly in early phases, consequently worsening the patient's outcome. Cerebral blood flow regulation is influenced by blood gas content, blood viscosity, body temperature, cardiac output, altitude, cerebrovascular autoregulation, and neurovascular coupling, mediated by chemical agents such as nitric oxide (NO), carbon monoxide (CO), eicosanoid products, oxygen-derived free radicals, endothelins, K+, H+, and adenosine. A better understanding of these factors is valuable for the management of neurocritical care patients. The assessment of both cerebral hemodynamics and metabolism in the acute phase of neurocritical care conditions may contribute to a more effective planning of therapeutic strategies for reducing secondary brain lesions. In this review, the authors have discussed concepts of cerebral hemodynamics, considering aspects of clinical importance.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500010&lng=en&tlng=enhemodinâmica cerebralfluxo sanguíneo cerebralautorregulação cerebralacoplamento neurovasculartraumatismo encefálicohemorragia subaracnóidea |
| spellingShingle | Edson Bor-Seng-Shu William S. Kita Eberval G. Figueiredo Wellingson S. Paiva Erich T. Fonoff Manoel J. Teixeira Ronney B. Panerai Cerebral hemodynamics: concepts of clinical importance Arquivos de Neuro-Psiquiatria hemodinâmica cerebral fluxo sanguíneo cerebral autorregulação cerebral acoplamento neurovascular traumatismo encefálico hemorragia subaracnóidea |
| title | Cerebral hemodynamics: concepts of clinical importance |
| title_full | Cerebral hemodynamics: concepts of clinical importance |
| title_fullStr | Cerebral hemodynamics: concepts of clinical importance |
| title_full_unstemmed | Cerebral hemodynamics: concepts of clinical importance |
| title_short | Cerebral hemodynamics: concepts of clinical importance |
| title_sort | cerebral hemodynamics concepts of clinical importance |
| topic | hemodinâmica cerebral fluxo sanguíneo cerebral autorregulação cerebral acoplamento neurovascular traumatismo encefálico hemorragia subaracnóidea |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500010&lng=en&tlng=en |
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