MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas
Objectives: Head and neck/oral cancer, predominantly head and neck squamous cell carcinoma (HNSCC), is the sixth most common cancer in the world. While substantial advances have been made to define the genomic alterations associated with head and neck/oral cancer, most studies are focused on protein...
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| Format: | Article |
| Language: | English |
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Lithuanian University of Health Sciences, Faculty of Odontology
2013-03-01
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| Series: | eJournal of Oral Maxillofacial Research |
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| Online Access: | http://www.ejomr.org/JOMR/archives/2013/1/e2/v4n1e2ht.htm |
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| author | Muzaffar Shah-Khan Yang Lu Anxun Wang Yi Jin Robert J. Cabay Dan Chen Xiaofeng Zhou |
| author_facet | Muzaffar Shah-Khan Yang Lu Anxun Wang Yi Jin Robert J. Cabay Dan Chen Xiaofeng Zhou |
| author_sort | Muzaffar Shah-Khan |
| collection | DOAJ |
| description | Objectives: Head and neck/oral cancer, predominantly head and neck squamous cell carcinoma (HNSCC), is the sixth most common cancer in the world. While substantial advances have been made to define the genomic alterations associated with head and neck/oral cancer, most studies are focused on protein coding genes. The aim of this article is to review the current literature on identified genomic aberrations of non-coding genes (e.g., microRNA) in head and neck/oral cancer (HNOC), and their contribution to the initiation and progression of HNOC. Material and Methods: A comprehensive review of the available literature relevant to microRNA deregulation in HNSCC/HNOC, was undertaken using PubMed, Medline, Scholar Google and Scopus. Keywords for the search were: microRNA and oral cancer, microRNA and squamous cell carcinoma, microRNA deregulation and oral cancer, microRNA and carcinogenesis in the head and neck/oral cavity. Only full length articles in the English language were included. Results: We recently identified a panel of microRNA deregulations that were consistently observed in HNSCC [Chen et al., Oral Oncol. 2012;48(8):686-91], including 7 consistently up-regulated microRNAs (miR-21, miR-7, miR-155, miR-130b, miR-223, miR-34b), and 4 consistently down-regulated microRNAs (miR-100, miR-99a, miR-125b, miR-375). In this review, we will first provide an overview on microRNA and HNSCC. We will then provide a comprehensive review on the roles of microRNA deregulations in HNSCC. The functional significance of the identified HNSCC-associated microRNAs and a number of other relevant microRNAs (e.g., miR-138, miR-98, miR-137, miR-193a and miR-218) will be discussed in detail. Conclusions: Based on current literature, microRNA deregulation plays a major role in head and neck/oral cancer. |
| format | Article |
| id | doaj-art-644c595f90f44dd4bec5b803215f4ceb |
| institution | DOAJ |
| issn | 2029-283X |
| language | English |
| publishDate | 2013-03-01 |
| publisher | Lithuanian University of Health Sciences, Faculty of Odontology |
| record_format | Article |
| series | eJournal of Oral Maxillofacial Research |
| spelling | doaj-art-644c595f90f44dd4bec5b803215f4ceb2025-08-20T03:14:42ZengLithuanian University of Health Sciences, Faculty of OdontologyeJournal of Oral Maxillofacial Research2029-283X2013-03-0141e210.5037/jomr.2013.4102MicroRNA Deregulations in Head and Neck Squamous Cell CarcinomasMuzaffar Shah-KhanYang LuAnxun WangYi JinRobert J. CabayDan ChenXiaofeng ZhouObjectives: Head and neck/oral cancer, predominantly head and neck squamous cell carcinoma (HNSCC), is the sixth most common cancer in the world. While substantial advances have been made to define the genomic alterations associated with head and neck/oral cancer, most studies are focused on protein coding genes. The aim of this article is to review the current literature on identified genomic aberrations of non-coding genes (e.g., microRNA) in head and neck/oral cancer (HNOC), and their contribution to the initiation and progression of HNOC. Material and Methods: A comprehensive review of the available literature relevant to microRNA deregulation in HNSCC/HNOC, was undertaken using PubMed, Medline, Scholar Google and Scopus. Keywords for the search were: microRNA and oral cancer, microRNA and squamous cell carcinoma, microRNA deregulation and oral cancer, microRNA and carcinogenesis in the head and neck/oral cavity. Only full length articles in the English language were included. Results: We recently identified a panel of microRNA deregulations that were consistently observed in HNSCC [Chen et al., Oral Oncol. 2012;48(8):686-91], including 7 consistently up-regulated microRNAs (miR-21, miR-7, miR-155, miR-130b, miR-223, miR-34b), and 4 consistently down-regulated microRNAs (miR-100, miR-99a, miR-125b, miR-375). In this review, we will first provide an overview on microRNA and HNSCC. We will then provide a comprehensive review on the roles of microRNA deregulations in HNSCC. The functional significance of the identified HNSCC-associated microRNAs and a number of other relevant microRNAs (e.g., miR-138, miR-98, miR-137, miR-193a and miR-218) will be discussed in detail. Conclusions: Based on current literature, microRNA deregulation plays a major role in head and neck/oral cancer.http://www.ejomr.org/JOMR/archives/2013/1/e2/v4n1e2ht.htmsquamous cell carcinoma of the head and neckmicroRNAcarcinogenesis tests. |
| spellingShingle | Muzaffar Shah-Khan Yang Lu Anxun Wang Yi Jin Robert J. Cabay Dan Chen Xiaofeng Zhou MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas eJournal of Oral Maxillofacial Research squamous cell carcinoma of the head and neck microRNA carcinogenesis tests. |
| title | MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas |
| title_full | MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas |
| title_fullStr | MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas |
| title_full_unstemmed | MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas |
| title_short | MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas |
| title_sort | microrna deregulations in head and neck squamous cell carcinomas |
| topic | squamous cell carcinoma of the head and neck microRNA carcinogenesis tests. |
| url | http://www.ejomr.org/JOMR/archives/2013/1/e2/v4n1e2ht.htm |
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