E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction‐Associated Steatohepatitis

E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction‐Associated Steatohepatitis

Abstract Macrophages are essential for the development of steatosis, hepatic inflammation, and fibrosis in metabolic dysfunction‐associated steatohepatitis(MASH). However, the roles of macrophage E2F2 in the progression of MASH have not been elucidated. This study reveals that the expression of macr...

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Bibliographic Details
Main Authors: Zheng Liu, Hao Wang, Yuan Liang, Mu Liu, Qiyuan Huang, Mingming Wang, Jinren Zhou, Qingfa Bu, Haoming Zhou, Ling Lu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
amino acid transportation
glycolysis
macrophage
metabolic dysfunction‐associated steatohepatitis
slc7a5
Online Access:https://doi.org/10.1002/advs.202410880
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