Effect of “Time To Surgery” on the Endometrial Cancer Prognosis
OBJECTIVE: Endometrial cancer is the most common gynecological cancer in developed countries. Our study aims to determine the effect of the time between diagnosis and surgery of endometrial cancer on the prognosis of the disease. STUDY DESIGN: Patients who were diagnosed with epithelial type endo...
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| Format: | Article |
| Language: | English |
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Medical Network
2022-03-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1202 |
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| _version_ | 1823857350445891584 |
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| author | Engin Celik Harika Yumru Celiksoy Hamdullah Sozen Hale Goksever Celik Semen Onder Mehmet Yavuz Salihoglu Samet Topuz |
| author_facet | Engin Celik Harika Yumru Celiksoy Hamdullah Sozen Hale Goksever Celik Semen Onder Mehmet Yavuz Salihoglu Samet Topuz |
| author_sort | Engin Celik |
| collection | DOAJ |
| description |
OBJECTIVE: Endometrial cancer is the most common gynecological cancer in developed countries. Our study aims to determine the effect of the time between diagnosis and surgery of endometrial cancer on the prognosis of the disease.
STUDY DESIGN: Patients who were diagnosed with epithelial type endometrial cancer and did not receive preoperative chemotherapy, radiotherapy, or hormonal therapy were included in the study.
RESULTS: Two hundred eighty-five patients were included in the study. We divided the patients into two groups regarding before and after 8 weeks from diagnosis to surgery. Clinical characteristics of the patients were comparable between the groups, except for comorbid conditions and body mass index. Using cox-regression analysis, time to operation did not have a significant effect on both recurrence and cancer-associated death risk. The log-rank test analysis also showed that there was no significant difference in progression-free survival and disease-specific survival between the patients. There was no significant difference between the groups in terms of progression-free survival and disease-specific survival for cases with endometrioid type grade 1-2 tumors. There was also no significant difference between the groups regarding progression-free survival and disease-specific survival in the patients with tumors of endometrioid type grade 3 and non-endometrioid histology.
CONCLUSION: Time delay between diagnosis to surgery of the patients with endometrial cancer has no prognostic importance for recurrence and survival outcomes.
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| format | Article |
| id | doaj-art-6446fc57e9534d21a8c335ffe1abea2f |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-6446fc57e9534d21a8c335ffe1abea2f2025-02-11T21:14:40ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182022-03-0128110.21613/GORM.2021.1202Effect of “Time To Surgery” on the Endometrial Cancer PrognosisEngin Celik0Harika Yumru Celiksoy1Hamdullah Sozen2Hale Goksever Celik3Semen Onder4Mehmet Yavuz Salihoglu5Samet Topuz6University of Health Sciences, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Department of Obstetrics and GynecologyIstanbul University, Istanbul Faculty of Medicine, Department of Gynecological OncologyIstanbul University, Istanbul Faculty of Medicine, Department of Gynecological OncologyKanuni Sultan Süleyman eğitim ve araştırma hastanesiIstanbul University, Istanbul Faculty of Medicine, Department of PathologyIstanbul University, Istanbul Faculty of Medicine, Department of Gynecological OncologyIstanbul University, Istanbul Faculty of Medicine, Department of Gynecological Oncology OBJECTIVE: Endometrial cancer is the most common gynecological cancer in developed countries. Our study aims to determine the effect of the time between diagnosis and surgery of endometrial cancer on the prognosis of the disease. STUDY DESIGN: Patients who were diagnosed with epithelial type endometrial cancer and did not receive preoperative chemotherapy, radiotherapy, or hormonal therapy were included in the study. RESULTS: Two hundred eighty-five patients were included in the study. We divided the patients into two groups regarding before and after 8 weeks from diagnosis to surgery. Clinical characteristics of the patients were comparable between the groups, except for comorbid conditions and body mass index. Using cox-regression analysis, time to operation did not have a significant effect on both recurrence and cancer-associated death risk. The log-rank test analysis also showed that there was no significant difference in progression-free survival and disease-specific survival between the patients. There was no significant difference between the groups in terms of progression-free survival and disease-specific survival for cases with endometrioid type grade 1-2 tumors. There was also no significant difference between the groups regarding progression-free survival and disease-specific survival in the patients with tumors of endometrioid type grade 3 and non-endometrioid histology. CONCLUSION: Time delay between diagnosis to surgery of the patients with endometrial cancer has no prognostic importance for recurrence and survival outcomes. https://gorm.com.tr/index.php/GORM/article/view/1202Disease-specific survivalEndometrial cancer Pandemic Progression-free survival Time to operation |
| spellingShingle | Engin Celik Harika Yumru Celiksoy Hamdullah Sozen Hale Goksever Celik Semen Onder Mehmet Yavuz Salihoglu Samet Topuz Effect of “Time To Surgery” on the Endometrial Cancer Prognosis Gynecology Obstetrics & Reproductive Medicine Disease-specific survival Endometrial cancer Pandemic Progression-free survival Time to operation |
| title | Effect of “Time To Surgery” on the Endometrial Cancer Prognosis |
| title_full | Effect of “Time To Surgery” on the Endometrial Cancer Prognosis |
| title_fullStr | Effect of “Time To Surgery” on the Endometrial Cancer Prognosis |
| title_full_unstemmed | Effect of “Time To Surgery” on the Endometrial Cancer Prognosis |
| title_short | Effect of “Time To Surgery” on the Endometrial Cancer Prognosis |
| title_sort | effect of time to surgery on the endometrial cancer prognosis |
| topic | Disease-specific survival Endometrial cancer Pandemic Progression-free survival Time to operation |
| url | https://gorm.com.tr/index.php/GORM/article/view/1202 |
| work_keys_str_mv | AT engincelik effectoftimetosurgeryontheendometrialcancerprognosis AT harikayumruceliksoy effectoftimetosurgeryontheendometrialcancerprognosis AT hamdullahsozen effectoftimetosurgeryontheendometrialcancerprognosis AT halegoksevercelik effectoftimetosurgeryontheendometrialcancerprognosis AT semenonder effectoftimetosurgeryontheendometrialcancerprognosis AT mehmetyavuzsalihoglu effectoftimetosurgeryontheendometrialcancerprognosis AT samettopuz effectoftimetosurgeryontheendometrialcancerprognosis |